Depresh Mode with John Moe

Maximum Fun

Mental Health, Comedy, John Moe, Comedy Interviews, Interview, Health & Fitness

5 • 777 Ratings

Overview

Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people who have been there and know their stuff. No shame, no stigma, and more laughs than you might expect.

247 Episodes

Maureen Johnson Became Friends with Her Anxiety Monster

The prolific, bestselling YA author shares tales of her anxiety and her teen detective’s.

Transcribed - Published: 1 December 2025

A Holiday Family Survival Mini-sode

Some tips from In This Family for getting along and getting through

Transcribed - Published: 26 November 2025

Esmé Weijun Wang’s Mind Convinced Her She Was Dead and In the Afterlife

The author of The Collected Schizophrenias shares an unusual mental health journey

Transcribed - Published: 24 November 2025

Is Your Mental Health Diagnosis an Identity or Something More Meaningless?

Author Sarah Fay says no mental health diagnosis is scientifically valid.

Transcribed - Published: 17 November 2025

The Personal Side of Huge Cuts to Addiction, Suicide Prevention, and Mental Health Programs

O. Rose Broderick from Stat unpacks what the budget and staffing slashes will mean

Transcribed - Published: 10 November 2025

Is Whiteness a Mental Health Problem? Dr. Jonathan Mathias Lassiter Thinks So.

He’s the author of the new book How I Know White People Are Crazy and Other Stories

Transcribed - Published: 27 October 2025

Is the U.S. Government Going To Take Away Your Antidepressants?

Maybe not yet but the fact that it’s an issue is reason to learn a lot more and fast.

Transcribed - Published: 20 October 2025

P.E. Moskowitz on Whether Your Mind is Broken or the World Is

The author and journalist explores drugs, trauma, and different ways to look at mental health

Transcribed - Published: 13 October 2025

Kendall Toole Gets Knocked Down, Never Knocked Out

The mental health advocate and former Peloton star opens up about dark times and finding resilience.

Transcribed - Published: 6 October 2025

Bruce Springsteen as Over-The-Counter Depression Treatment

Anne Abel’s life was changed by a Springsteen concert. So she flew to Australia for eight more.

Transcribed - Published: 29 September 2025

Emma Swift Had a Complete Mental Breakdown. Found Health. Made Music About It.

The Nashville-based singer-songwriter’s new album, The Resurrection Game, goes to very dark and very real places.

Transcribed - Published: 22 September 2025

Sycophantic Chatbots and Alarming Cases of “AI Psychosis”

Reporter Maggie Harrison Dúpre on the unregulated and potentially dangerous world of AI

Transcribed - Published: 15 September 2025

Alex Edelman on ADHD, Grief, Infiltrating White Nationalists, and The Paper

The Emmy and Tony-winning comedian and actor in a broad illuminating conversation

Transcribed - Published: 8 September 2025

Better Home Design for Better Mental Health with Dr. Beverly Walpole

Plus, a brief rundown on why host John Moe does what he does on this show

Transcribed - Published: 1 September 2025

Denise Winkelman: Comedian/Trans Woman/Former Pro Wrestler/Chronic Pain Sufferer

“Bougie on a Budget”, her debut special, is now streaming

Transcribed - Published: 25 August 2025

Ashly Burch Delivers Mental Health Insight Using Puppets and Swear Words

The actor and creator has a new online show, I’m Happy You’re Here

Transcribed - Published: 18 August 2025

Author/Comedian Tiffany Jenkins on Anxiety, Addiction, Felonies, Success, and Not Wanting to Exist

She’s stopped doing press as she tends to her mental health. But she did this one.

Transcribed - Published: 11 August 2025

We Have Two Guests This Week: Comedian Aaron Foster and His Depression

Having been an artist, a TV host, and a restaurateur, he quit it all in his fifties to become a comedian.

Transcribed - Published: 4 August 2025

Nurse Blake on Gay Conversion Therapy, Panic Attacks, and, Well, Nursing

He sees himself less as a comedian, more as a nursing advocate who happens to do comedy.

Transcribed - Published: 28 July 2025

Gavin Rossdale of Bush on Loss, Xanax, and New Emotional Landscapes

The band has a new album centered on mental health and Gavin opens up about his own.

Transcribed - Published: 21 July 2025

Insomnia and Mental Health Problems: Each Horrible, Each Feeding the Other

Award-winning writer Jen Senior on the overlap of lack of sleep and mental illness

Transcribed - Published: 14 July 2025

Prison, Addiction, Bipolar, and Four Loko with Author Brandon Stickney

Mental illness and treatment can be pretty different when you’re behind bars

Transcribed - Published: 7 July 2025

Ginny & Georgia Creator Sarah Lampert on Getting Mental Health Right On Screen

It’s the number one show on Netflix and it takes a truthful and considered look at important issues.

Transcribed - Published: 23 June 2025

Alexandra Savior on bipolar disorder and being discovered by Courtney Love

Alexandra Savior's mental health journey has informed her work as a songwriter and inspired the songs on her latest album, Beneath the Lilypad.

Transcribed - Published: 16 June 2025

You’re Not Imagining It, Climate Change IS Messing With Your Mental Health

Depression, anxiety, and trauma response are all linked to a warming, changing planet

Transcribed - Published: 9 June 2025

Can a Bipartisan Congressional Caucus Save Mental Health in America?

And a conversation with one of our listeners about hope, hopelessness, and moving forward.

Transcribed - Published: 2 June 2025

Ethan Sacks and Daughter Naomi Tackle Mental Health in Comics Form with A Haunted Girl

Using the supernatural, horror, and a comics format to tell an honest tale of mental illness

Transcribed - Published: 26 May 2025

The Head And The Heart’s Kenny Hensley Injured Both Shoulders and That’s Where the Trouble Started

The band’s piano player tells of his journey through anxiety, addiction, and recovery.

Transcribed - Published: 12 May 2025

988’s Future, Funding, and Online Fables

An update with NAMI’s Hannah Wesolowski on the state of the Suicide & Crisis Lifeline.

Transcribed - Published: 5 May 2025

Generative AI Chatbot Delivers Great Results for Mental Health. Is “Therabot” the Future?

Dr. Nicholas Jacobson of Dartmouth believe his chatbot provides legitimate treatment and care.

Transcribed - Published: 28 April 2025

Perfectly Hidden Depression: Do You Have It? With Dr. Margaret Rutherford

Masking your pain behind a mask of perfectionism has a way of catching up with you.

Transcribed - Published: 21 April 2025

Cameron Esposito on Comedy, Rehab, and Bipolar Disorder

The veteran standup comic makes sense of a post-diagnosis life and career.

Transcribed - Published: 14 April 2025

The Thorny Issue of Airline Pilots and Mental Illness

Dr. Helen Ouyang of The New York Times Magazine on treatment, disclosure, and safety.

Transcribed - Published: 7 April 2025

Hanif Abdurraqib on Cultivating a Support System, Depression, Anxiety, and Basketball

The acclaimed author talks about living with mental illness and making a beautiful life.

Transcribed - Published: 31 March 2025

Checking in With Friends: Open Mike Eagle

We touch base during difficult times with the acclaimed rapper and comedian

Transcribed - Published: 26 March 2025

Welcome, New Listeners

If You’re New (or Even If You’re Not), I’m Glad You’re Here

Transcribed - Published: 25 March 2025

Jim James of My Morning Jacket on Depression, EMDR, Gratitude, and Taking Care of Jim

The singer and band leader has gone on a long journey to improve his mental health. And it’s working.

Transcribed - Published: 24 March 2025

BONUS CONTENT PREVIEW: Depresh Mode: The Game Show

A sneak preview of this year’s bonus content special: Maximum Fun all-stars play some very light-hearted and delightfully competitive games that are as informative as they are silly

Transcribed - Published: 20 March 2025

John Moe helps kick off MFD Spring Break

Transcribed - Published: 17 March 2025

J. Kenji Lopez-Alt on Food, Booze, Weed, Anxiety, Depression, and Living a Healthy Life

The food celebrity has found sobriety after many years and says it doesn’t look like some people think

Transcribed - Published: 17 March 2025

Checking in With Friends During Scary Times: Paul F. Tompkins, Ana Marie Cox, and Gary Gulman

We are living in an interesting and intense moment in history. Let’s touch base with our friends.

Transcribed - Published: 10 March 2025

Heavy Substance Use, Heavy Depression, and Heavy Metal with Randy Blythe from Lamb of God

The band’s lead singer and lyricist shares insight on navigating a complicated life

Transcribed - Published: 3 March 2025

Microdosing with James Fadiman and Jordan Gruber

Anecdotal evidence is yielding very positive results for treatment-resistant depression and more.

Transcribed - Published: 24 February 2025

Surviving Trauma and Having a Few Laughs with Ophira Eisenberg

The acclaimed writer, comedian, and podcast host opens up about major events in her life.

Transcribed - Published: 17 February 2025

Your Vagus Nerve: Key to Depression Relief? / Actor-Writer Kit Williamson

Would you get a device the size of a Nilla wafer implanted in your body if it meant relief? And actor and writer Kit Williamson, creator of the new series 'Unconventional'

Transcribed - Published: 10 February 2025

Neko Case on Pain, Neglect, Music, and Confidence

The beloved singer-songwriter has a new memoir, The Harder I Fight The More I Love You

Transcribed - Published: 3 February 2025

Dr. Emily Nagoski on Sex, Long Term Relationships, and Depression

The acclaimed researcher and educator on how to have a more fulfilling sex life.

Transcribed - Published: 27 January 2025

Hari Kondabolu’s Life Was Transformed in Seattle

The comedian opens up about panic attacks, depression, therapy, and the Pacific Northwest

Transcribed - Published: 20 January 2025

When Treating One Problem Creates A Whole Other Problem, with Alex Goldman

The podcast host’s ADHD treatment set off hypomanic episodes consistent with bipolar II

Transcribed - Published: 13 January 2025

Truly Depressing Movies with Dana Stevens, Dan McCoy, and Drea Clark

Is there hidden value in films that are unrelentingly bleak and hopeless?

Transcribed - Published: 6 January 2025

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