Depresh Mode with John Moe

Maximum Fun

Mental Health, Comedy, John Moe, Comedy Interviews, Interview, Health & Fitness

5 • 777 Ratings

Overview

Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people who have been there and know their stuff. No shame, no stigma, and more laughs than you might expect.

233 Episodes

Denise Winkelman: Comedian/Trans Woman/Former Pro Wrestler/Chronic Pain Sufferer

“Bougie on a Budget”, her debut special, is now streaming

Transcribed - Published: 25 August 2025

Ashly Burch Delivers Mental Health Insight Using Puppets and Swear Words

The actor and creator has a new online show, I’m Happy You’re Here

Transcribed - Published: 18 August 2025

Author/Comedian Tiffany Jenkins on Anxiety, Addiction, Felonies, Success, and Not Wanting to Exist

She’s stopped doing press as she tends to her mental health. But she did this one.

Transcribed - Published: 11 August 2025

We Have Two Guests This Week: Comedian Aaron Foster and His Depression

Having been an artist, a TV host, and a restaurateur, he quit it all in his fifties to become a comedian.

Transcribed - Published: 4 August 2025

Nurse Blake on Gay Conversion Therapy, Panic Attacks, and, Well, Nursing

He sees himself less as a comedian, more as a nursing advocate who happens to do comedy.

Transcribed - Published: 28 July 2025

Gavin Rossdale of Bush on Loss, Xanax, and New Emotional Landscapes

The band has a new album centered on mental health and Gavin opens up about his own.

Transcribed - Published: 21 July 2025

Insomnia and Mental Health Problems: Each Horrible, Each Feeding the Other

Award-winning writer Jen Senior on the overlap of lack of sleep and mental illness

Transcribed - Published: 14 July 2025

Prison, Addiction, Bipolar, and Four Loko with Author Brandon Stickney

Mental illness and treatment can be pretty different when you’re behind bars

Transcribed - Published: 7 July 2025

Ginny & Georgia Creator Sarah Lampert on Getting Mental Health Right On Screen

It’s the number one show on Netflix and it takes a truthful and considered look at important issues.

Transcribed - Published: 23 June 2025

Alexandra Savior on bipolar disorder and being discovered by Courtney Love

Alexandra Savior's mental health journey has informed her work as a songwriter and inspired the songs on her latest album, Beneath the Lilypad.

Transcribed - Published: 16 June 2025

You’re Not Imagining It, Climate Change IS Messing With Your Mental Health

Depression, anxiety, and trauma response are all linked to a warming, changing planet

Transcribed - Published: 9 June 2025

Can a Bipartisan Congressional Caucus Save Mental Health in America?

And a conversation with one of our listeners about hope, hopelessness, and moving forward.

Transcribed - Published: 2 June 2025

Ethan Sacks and Daughter Naomi Tackle Mental Health in Comics Form with A Haunted Girl

Using the supernatural, horror, and a comics format to tell an honest tale of mental illness

Transcribed - Published: 26 May 2025

The Head And The Heart’s Kenny Hensley Injured Both Shoulders and That’s Where the Trouble Started

The band’s piano player tells of his journey through anxiety, addiction, and recovery.

Transcribed - Published: 12 May 2025

988’s Future, Funding, and Online Fables

An update with NAMI’s Hannah Wesolowski on the state of the Suicide & Crisis Lifeline.

Transcribed - Published: 5 May 2025

Generative AI Chatbot Delivers Great Results for Mental Health. Is “Therabot” the Future?

Dr. Nicholas Jacobson of Dartmouth believe his chatbot provides legitimate treatment and care.

Transcribed - Published: 28 April 2025

Perfectly Hidden Depression: Do You Have It? With Dr. Margaret Rutherford

Masking your pain behind a mask of perfectionism has a way of catching up with you.

Transcribed - Published: 21 April 2025

Cameron Esposito on Comedy, Rehab, and Bipolar Disorder

The veteran standup comic makes sense of a post-diagnosis life and career.

Transcribed - Published: 14 April 2025

The Thorny Issue of Airline Pilots and Mental Illness

Dr. Helen Ouyang of The New York Times Magazine on treatment, disclosure, and safety.

Transcribed - Published: 7 April 2025

Hanif Abdurraqib on Cultivating a Support System, Depression, Anxiety, and Basketball

The acclaimed author talks about living with mental illness and making a beautiful life.

Transcribed - Published: 31 March 2025

Checking in With Friends: Open Mike Eagle

We touch base during difficult times with the acclaimed rapper and comedian

Transcribed - Published: 26 March 2025

Welcome, New Listeners

If You’re New (or Even If You’re Not), I’m Glad You’re Here

Transcribed - Published: 25 March 2025

Jim James of My Morning Jacket on Depression, EMDR, Gratitude, and Taking Care of Jim

The singer and band leader has gone on a long journey to improve his mental health. And it’s working.

Transcribed - Published: 24 March 2025

BONUS CONTENT PREVIEW: Depresh Mode: The Game Show

A sneak preview of this year’s bonus content special: Maximum Fun all-stars play some very light-hearted and delightfully competitive games that are as informative as they are silly

Transcribed - Published: 20 March 2025

John Moe helps kick off MFD Spring Break

Transcribed - Published: 17 March 2025

J. Kenji Lopez-Alt on Food, Booze, Weed, Anxiety, Depression, and Living a Healthy Life

The food celebrity has found sobriety after many years and says it doesn’t look like some people think

Transcribed - Published: 17 March 2025

Checking in With Friends During Scary Times: Paul F. Tompkins, Ana Marie Cox, and Gary Gulman

We are living in an interesting and intense moment in history. Let’s touch base with our friends.

Transcribed - Published: 10 March 2025

Heavy Substance Use, Heavy Depression, and Heavy Metal with Randy Blythe from Lamb of God

The band’s lead singer and lyricist shares insight on navigating a complicated life

Transcribed - Published: 3 March 2025

Microdosing with James Fadiman and Jordan Gruber

Anecdotal evidence is yielding very positive results for treatment-resistant depression and more.

Transcribed - Published: 24 February 2025

Surviving Trauma and Having a Few Laughs with Ophira Eisenberg

The acclaimed writer, comedian, and podcast host opens up about major events in her life.

Transcribed - Published: 17 February 2025

Your Vagus Nerve: Key to Depression Relief? / Actor-Writer Kit Williamson

Would you get a device the size of a Nilla wafer implanted in your body if it meant relief? And actor and writer Kit Williamson, creator of the new series 'Unconventional'

Transcribed - Published: 10 February 2025

Neko Case on Pain, Neglect, Music, and Confidence

The beloved singer-songwriter has a new memoir, The Harder I Fight The More I Love You

Transcribed - Published: 3 February 2025

Dr. Emily Nagoski on Sex, Long Term Relationships, and Depression

The acclaimed researcher and educator on how to have a more fulfilling sex life.

Transcribed - Published: 27 January 2025

Hari Kondabolu’s Life Was Transformed in Seattle

The comedian opens up about panic attacks, depression, therapy, and the Pacific Northwest

Transcribed - Published: 20 January 2025

When Treating One Problem Creates A Whole Other Problem, with Alex Goldman

The podcast host’s ADHD treatment set off hypomanic episodes consistent with bipolar II

Transcribed - Published: 13 January 2025

Truly Depressing Movies with Dana Stevens, Dan McCoy, and Drea Clark

Is there hidden value in films that are unrelentingly bleak and hopeless?

Transcribed - Published: 6 January 2025

Cory Richards on Climbing Mountains, Wrestling with Mental Health, Owning Up to His Past

The famed mountaineer and photographer has a new book and some blunt self-assessments

Transcribed - Published: 23 December 2024

Lead in Gasoline Has Damaged Your Mental Health and IQ, with Dr. Aaron Reuben

It’s impacted everyone but hit Generation X most of all

Transcribed - Published: 16 December 2024

Richard Sarvate’s Mom Had Problematic Schizophrenia but Made Some Mean Chapatis

What becomes of a kid when his mother thinks he’s trying to kill her?

Transcribed - Published: 9 December 2024

Comedian Ellie Hino and Her Later-In-Life ADHD Diagnosis

The veteran stand-up went through the full battery of tests and found a path to better health.

Transcribed - Published: 2 December 2024

David Shaw of The Revivalists Finds His Heart Mode

The singer-songwriter has a new album and talks anxiety, substance use, and a better path.

Transcribed - Published: 25 November 2024

LISTENER’S CHOICE: Adventures in the Army with the Bipolar General

Gregg Martin’s disorder worked well for him in the military. Until it didn’t.

Transcribed - Published: 18 November 2024

Comedian Youngmi Mayer on Cultural Dissonance, Depression, Anxiety, Trauma, and Barry Gibb

Her memoir I’m Laughing Because I’m Crying is a journey of geography, family, and mental health

Transcribed - Published: 11 November 2024

13 Reasons For Hope in Mental Health

We can’t wipe out anxiety in one podcast episode but we can look toward a better possible future.

Transcribed - Published: 4 November 2024

Mysterious Cancellations Block Veterans’ Mental Health Care

Patricia Kime from Military.com shares the story of a troubling phenomenon.

Transcribed - Published: 28 October 2024

The Promising World of Precision Treatment for Depression

Dr. Leanne Williams on identifying brain patterns and matching them with specific treatments.

Transcribed - Published: 21 October 2024

Bishop Briggs on Loss, Despair, and Finding Hope

The singer has a new album, delightfully titled Tell My Therapist I’m Fine

Transcribed - Published: 14 October 2024

Dr. Jessi Gold and the Precarious Mental Health of the Medical Profession

Covid, burnout, depression, and the stress of being a care provider.

Transcribed - Published: 7 October 2024

Xiu Xiu’s Jamie Stewart on Charting a Healing Path from Trauma

The band’s founder and leader has a new album and a positive outlook

Transcribed - Published: 30 September 2024

Zac Carper of FIDLAR on Bipolar, Drugs, Meds, and Intense Journaling

His band has a new album, Surviving the Dream, and he has a new diagnosis and a new set of challenges.

Transcribed - Published: 23 September 2024

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