The Human Upgrade with Dave Asprey

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.  In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.  You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.  Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.  What You Will Learn in This Episode: • Why testosterone matters for men and women at every age • The real causes of the global testosterone crash • Why diet, sleep, and exercise cannot fully fix low testosterone • How testosterone drives dopamine, motivation, and longevity • The breakthrough that makes oral testosterone safe and effective • How Kyzatrex® lowers SHBG and boosts free testosterone naturally • Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan • How to safely use testosterone therapy without suppressing fertility or causing side effects  ** Visit livethrive.com/asprey to get a discount on your first month's supply! **  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Purchase Kyzatrex® –  https://thesmarthuman.com/ • Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 Trailer 00:52 Introduction 01:29 Global Decline in Testosterone Levels 02:27 Symptoms of Low Testosterone 03:48 Personal Journey with Testosterone Therapy 05:06 The Role of Testosterone in Overall Health 06:18 Testosterone Levels in Men and Women 08:48 Challenges and Innovations in Testosterone Delivery 16:25 The Importance of Circadian Rhythm in Testosterone Therapy 19:19 The Future of Testosterone Therapy 32:00 Investment and Development in Testosterone Therapy 34:57 Introduction to FDA and Hormone Replacement 35:31 FDA’s Impact on Women’s Health 36:10 Testosterone and Cardiovascular Risk 39:05 Testosterone and Depression 40:30 Testosterone Testing and Misconceptions 44:58 The Testosterone Project and Female Hormone Therapy 47:51 Testosterone’s Role in Longevity and Health 55:37 Cost and Accessibility of Testosterone Therapy 01:04:03 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 9 May 2025

Your environment is rewiring your hormones, fertility, and long-term health without your consent. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity.  What You’ll Learn in This Episode: • How chemicals in household, cleaning, and beauty products disrupt hormones • The link between environmental toxins, autoimmune disease, thyroid issues, and infertility • Hidden sources of microplastics and PFAS chemicals and how to eliminate them • Affordable, practical steps to detox your home, water, and personal care routine • Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience   THANK YOU TO OUR SPONSORS! -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.  -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Aly’s Website –  https://thesmarthuman.com/ • Aly's Website - https://alycohenmd.com/ • Aly’s New Book – Detoxify: https://alycohenmd.com/books • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 Trailer 02:01 Introduction 02:15 Rheumatism and Rheumatology 03:36 Autoimmune Diseases and Toxins 04:17 Chemical Impact on Health 04:49 Personal Health Journey 06:15 Microplastics and Immune Disruption 08:21 Resilience and Lifestyle Changes 21:45 Nutritional Deficiencies 26:48 Lab Results and Assessments 34:40 Detoxification and Resilience 41:14 Personal Journey Continued 42:22 Clean Drinking Water 44:20 Travel Hacks for Water 46:15 Hotel Room Detox Tips 50:06 EPA Water Standards 53:06 Restaurant Toxins and Home Safety 55:36 Top Toxic Household Items 01:08:31 Synthetic Materials Impact 01:13:30 Final Thoughts and Book See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 8 May 2025

What if you could reverse the age of your heart...without leaving home?  In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.  Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.  What You’ll Learn in This Episode: • The link between mitochondrial decline and heart failure • Why women’s cardiac risk skyrockets after menopause • How Urolithin A stimulates mitophagy and energy renewal • New human clinical data on reversing cardiac aging markers • Biohacking strategies to fortify your cardiovascular health • How to optimize endurance, recovery, and heart resilience   THANK YOU TO OUR SPONSORS! -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.  -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Timeline Website –  https://www.timeline.com/partners/dave-asprey • Timeline Instagram - https://www.instagram.com/timeline_longevity/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 — Trailer • 02:11 — Supplements that help • 03:05 — Long-term benefits • 04:38 — Stacking with lifestyle • 22:19 — Heart health connection • 29:39 — Mitochondria & brain function • 33:04 — Glymphatic system & Alzheimer’s • 33:53 — Bed height & brain health • 34:18 — Why mitochondria matter • 35:43 — Inflammation & dysfunction • 38:12 — Transplants & consciousness • 39:19 — Meditation’s effects • 40:33 — The ultimate biohacking stack • 43:06 — Creatine for sleep & focus • 50:00 — Fertility insights • 57:23 — Skin health • 01:00:28 — Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 6 May 2025

What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwaves, heal trauma, and even influence states of consciousness. Dr. Crawford explains how specific laser frequencies are being used to modulate brain states, activate the vagus nerve, improve mood, restore gut-brain communication, and support recovery from conditions like autism and ALS. From EEG shifts to structured water and mitochondrial signaling, this conversation dives deep into biohacking’s most advanced light-based tech.  What You’ll Learn in This Episode: • How laser therapy rewires brainwaves for mood, focus, and clarity • The exact brain regions linked to embodiment, intuition, and flow • Why pulsing patterns matter more than power in laser tech • How light influences trauma recovery and vagus nerve activation • The role of structured water and infrared light in cellular repair • How patients with ALS and autism responded to 528 protocols ** Get 30% off GA Virtual Tickets for the Biohacking Conference this May with code ‘528i30’ at checkout! **  THANK YOU TO OUR SPONSORS! -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 528 Innovations Website and used code ‘UPGRADE10’ at checkout –  https://528innovations.com/dave • 528 Innovations Instagram - https://www.instagram.com/528innovations/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 02:00 – Intro • 02:26 – New breakthroughs in laser therapy • 03:07 – Why laser tech needed reinvention • 04:21 – How laser light influences the brain • 08:03 – Holograms, light, and reality • 09:02 – Telepathy and autism connections • 12:03 – Rewiring the brain with light • 20:01 – Quantum signaling between cells • 22:33 – Biohacking and yogic practices • 22:54 – Testosterone and natural living • 23:37 – Boosting testosterone with lasers • 25:21 – Mitochondria and higher awareness • 27:35 – Laser benefits across the body • 30:29 – Advanced brain stimulation tech • 36:19 – ALS recovery and healing cases • 40:48 – Closing thoughts and next steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 1 May 2025

What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution? In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape consciousness, drive healing, and accelerate human evolution. You’ll discover why chronic disease, fatigue, brain fog, and emotional trauma often trace back to lost cellular communication—and how restoring that network can unlock radical resilience, deeper energy, and true longevity. Through the lens of soil health, vibrational biology, light frequencies, and ancient microbial wisdom, Zach Bush shows why the future of biohacking demands reconnection to the deeper intelligence already alive inside you.  What You’ll Learn in This Episode: • How mitochondria act as conscious messengers—not just energy factories—and why that changes everything about health and aging • Why rebuilding gut microbiome intelligence strengthens immune function, brain health, and emotional resilience • How disrupted cellular communication fuels chronic inflammation, autoimmune disease, and premature aging • How emotional trauma imprints onto genetic expression and triggers mitochondrial collapse • Why viruses and bacteria serve as evolutionary partners—not enemies—and how they upgrade your biology • How “cellular safety” activates healing, regeneration, and peak human performance • How carbon cycles, soil health, and light frequencies repair DNA and extend human lifespan • Simple daily practices that rebuild cellular coherence, boost energy, and reconnect you to your innate intelligence  This conversation will rewire how you think about health, disease, and human potential—giving you the tools to upgrade your biology at the deepest level.  **Check out Zach's exclusive offer for The Human Upgrade listeners at https://intelligenceofnature.com/ and use code ‘DAVE10” for a discount!**  SPONSORS - ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  - Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Zach’s Website –  https://zachbushmd.com/ • Zach’s Instagram - https://www.instagram.com/zachbushmd/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 Trailer • 00:52 Intro: Microbiome and Human Connection • 03:07 Microbiome’s Role in Nutrition and Health • 05:48 Chemical Farming’s Impact on Soil and Health • 09:23 Mitochondria and Cellular Communication • 26:00 Viruses, Exosomes, and Evolution • 34:36 The Observer Effect and Reality • 40:08 Tech vs. Nature in Healing • 41:04 Light, Mitochondria, and Cellular Energy • 42:01 Choosing Tech or Natural Regeneration • 43:44 The Miracle of Life and Human Potential • 45:05 Healing Generational Trauma • 47:38 Shamanic States and Connection • 01:05:48 Sacred Geometry and Group Healing • 01:12:48 Rational vs. Mystical Perspectives • 01:14:52 Finding Common Ground • 01:15:10 Inside the Supplement Room • 01:15:47 Emerging Tech in Biohacking • 01:15:58 Non-Tech Health Upgrades • 01:16:11 Stem Cell Concerns and Cautions • 01:17:31 Nature Deficit and Health Impacts • 01:19:09 Curiosity and Personal Growth • 01:20:56 Generational Shifts and Gender • 01:24:20 Strengthening Relationships Through Differences • 01:28:31 Storytelling’s Power Over Data • 01:38:24 Longevity and Embracing Elderhood • 01:44:47 Final Thoughts and Future Visions See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 29 April 2025

You’ve probably heard of HIIT—but have you heard of “REHIT?”  This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that’s obliterating fitness myths.  Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase • 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week.  But what is it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows exactly how a brand-new way of exercising is giving explosive results—no matter your age or fitness level.  What You’ll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you’re traveling or don’t have access to the tech  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE’ for a discount –  https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey’s Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 25 April 2025

You’ve probably heard of HIIT—but have you heard of “REHIT?”  This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that’s obliterating fitness myths.  Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase• 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week.  But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive results—no matter your age or fitness level.  What You’ll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you’re traveling or don’t have access to the tech  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE’ for a discount –  https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey’s Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 25 April 2025

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse. In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy. Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If you’ve ever felt dismissed by “perfect” bloodwork, this conversation will rewire how you think about sickness—and show you how to reclaim real, lasting wellness.  What You’ll Learn in This Episode: • Why your bloodwork can be “perfect” while your cells are on fire • The overlooked hormone resistances sabotaging your energy and metabolism • The 3-legged stool of chronic illness—and what actually drives disease • What “upstream detox” really means, and why most cleanses make you worse • Why toxins trigger genetic expression (and how to shut that down) • How to fix unexplainable fatigue, anxiety, and weight gain from the inside out • Why true healing starts with fixing the cell, not the symptom  It’s time to stop chasing symptoms—and start upgrading from the root.  **Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code ‘10OFF’ for a discount!**  SPONSORS -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Pompa’s Website –  https://drpompa.com/ • Dr. Pompa’s Instagram - https://www.instagram.com/drpompa/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 Trailer • 00:55 Intro • 01:10 Healthy Is the New Sick • 02:27 Bloodwork & Hormone Resistance • 04:32 Dr. Pompa’s Health Collapse • 08:38 Toxins & Environmental Triggers • 15:01 Why Most Detox Fails • 29:16 The 5 Rs of Cellular Healing • 37:06 Olive Oil: Cure or Concern? • 38:11 Fat Balance for Energy • 42:13 Cholesterol & Saturated Fat • 46:26 Restoring Cellular Energy • 51:08 The Power of Diet Variation • 56:57 Plant Toxins Explained • 01:03:28 Emotional & Spiritual Detox • 01:13:55 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 24 April 2025

Most people run from stress. The world’s highest performers run toward it. Sébastien Page manages over $500 billion in global assets. He’s the CIO of one of the world’s largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control. But here’s the twist: this isn’t just about boardrooms or billion-dollar trades. Whether you’re running a company, chasing a deadline, or just trying to stop procrastinating on your goals—this conversation will flip what you think you know about pressure, performance, and productivity. You’ll learn why trying to “relax your way to success” doesn’t work—and how to harness discomfort to create better decisions, higher output, and more resilience in every part of life.  What You’ll Learn in This Episode: • The psychology of stress and why zero stress leads to burnout • How procrastination can boost creative performance • What astronauts, athletes, and leaders have in common • Why the key to better decisions is strategic patience, not speed • The stress-performance curve no one taught you in school • Why losing is the real path to mastery (and what Roger Federer can teach you) • The difference between being nice vs. being kind—and why it matters  It's time to start turning stress into strategy.  SPONSORS -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Sébastien’s New Book –The Psychology of Leadership –  https://www.psychologyofleadership.net/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com   Timestamps: • 00:00 Intro • 02:00 Book Launch & Setup • 02:45 Buy or Sell? Market Insights • 03:20 Stress and Performance • 04:28 Sports Psychology Breakdown • 09:48 Federer & the Power of Losing • 26:42 Rethinking Feedback • 31:32 Stress as a Tool • 44:10 Listening as Leadership • 44:17 Traits of Great Leaders • 44:54 Psychology for Entrepreneurs • 45:37 Leading Beyond Work • 46:09 Sleep Tracking Anxiety • 47:39 Channeling Stress • 49:04 Extreme Pressure Moments • 50:42 The Corporate Athlete • 59:08 Vulnerability & Leadership • 01:05:23 Goal-Induced Blindness • 01:12:34 Finding Meaning at Work • 01:18:08 Leadership at Home • 01:20:27 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 22 April 2025

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you. But what if there was a way to take it back… and hack the system? In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data. Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away. From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself.  What You’ll Learn in This Episode: • Why your DNA is already in government databases—and how long they keep it • How Nillion enables secure computation on private data • What it means to build a “cybernetic operating system” for your body • Why Fulcra.ai is building the orchestration layer of human optimization • How Monadic DNA helps you profit from your genetics—without giving them away • Why owning your data is the next frontier of biohacking • The surprising connection between decentralization, health freedom, and consciousness • How to join the movement toward true data sovereignty  If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body.  **Join the Fulca sleep study today! Visit https://fulcra.ai/sleep to sign up** **Get a 30% discount on Fulca with code “DAVE”!   SPONSORS -IGNITON | Go to https://www.biohackingconference.com/ and get your tickets while there are still great discounts available. Learn more at https://igniton.com/.  -Calroy | Head to https://calroy.com/dave for an exclusive discount.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Fulcra Dynamics Website –  https://www.fulcradynamics.com/ • MonadicDNA Website: https://monadicdna.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 02:01 – Intro • 02:26 – Data Privacy & AI: The Big Shift • 03:21 – Meet Michael Tiffany • 04:41 – Cybernetic Operating Systems • 05:13 – Wearables & Personal Augmentation • 08:21 – Meet Vishakh: DNA Privacy Mission • 09:25 – Why Genetic Data Needs Protection • 11:30 – New Tech: Encryption & Privacy Tools • 16:13 – How Multi-Party Compute Works • 41:58 – Emergence: Behavior & Systems • 49:11 – Meditation & Mental Reprogramming • 50:20 – Distributed Computing & Biology • 56:15 – Environment Shapes Potential • 57:57 – Empowering Individuals at Scale • 01:00:31 – Biohacking Meets Inner Awareness • 01:04:01 – The Dark Side of DIY Mind Hacks • 01:06:09 – Future of Biohacking & Community• 01:12:28 – Integrating Genetic & Life Data • 01:20:39 – Why We Started Biohacking • 01:25:01 – Favorite Current Biohacks • 01:31:41 – Final Thoughts & Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 17 April 2025

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior. Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones. Most shocking of all? Microbes may not just influence addiction—they may cause it.  What You’ll Learn in This Episode: • How your gut microbiome can hijack your brain and influence your thoughts and behavior • Why certain microbes may actually cause addiction, obesity, and depression • How antibiotics, glyphosate, and processed foods are turning your gut into a desert • How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs • Why food cravings might be microbial mind control—and what to do about it • What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation  Sponsors: -Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400.  -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Gundry’s Instagram –  https://www.instagram.com/drstevengundry/?hl=en • Dr. Gundry’s Website: https://drgundry.com/ • Dr. Gundry’s New Book The Gut-Brain Paradox: https://www.barnesandnoble.com/w/the-gut-brain-paradox-steven-r-gundry-md/1146019686?ean=9780062911803 • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 — Trailer • 02:01 — Intro • 03:55 — The Gut-Brain Connection • 04:45 — Microbiome Communication and Control • 08:19 — The Role of Fungi and Plants • 11:29 — Microbiome Diversity and Health • 19:05 — Addictive Microbiome and Behavior • 28:17 — Antibiotics and Gut Health • 30:49 — Listener Concerns and Gut Health • 31:02 — Whale Watching and Climate Change • 32:58 — Understanding SIBO and Bacterial Migration • 34:02 — The Role of Soluble Fiber and Fermented Foods • 36:12 — Complexity of Gut Microbiome • 36:49 — Restoring Ecosystems and Gut Health • 38:23 — Precision Microbiome Manipulation • 41:31 — Calcium Formation and Gut Bacteria • 43:56 — Oxalates vs. Lectins Debate • 46:04 — Whole Foods and Glyphosate Concerns • 51:47 — Dopamine Levels and Gut Health • 54:59 — Conclusion and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 15 April 2025

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong? For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that? In this episode, Dave Asprey uncovers the cellular biology of hair thinning with longevity researcher Carolina Reis Oliveira. You’ll learn how senescent cells (aka zombie cells) hijack your scalp, disrupt follicle function, and silently accelerate hair loss—and how a breakthrough peptide might stop it cold. Carolina reveals brand-new clinical research on OS-01, a molecule shown to increase hair density by 40% in just 6 months. But this isn’t a product pitch—it’s a paradigm shift. Together, they explore the hidden drivers of hair aging, from hormone shifts and stress cascades to microbiome imbalances and inflammation, plus the real science behind what can actually regrow hair.  What You’ll Learn in This Episode: • How “zombie cells” (senescent cells) sabotage your hair from the inside out • The science behind the OS-01 peptide and how it reverses visible hair thinning • Why thinning hair isn’t just genetic—and what else is driving it • How stress, hormones, and aging collide to trigger follicle dysfunction • What your scalp microbiome has to do with regrowth and hair density • How to stack red light, peptides, and topicals for real, measurable results   ***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.***  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • OneSkin Instagram –  https://www.instagram.com/oneskin.co/ • OneSkin Website: https://www.oneskin.co/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 — Trailer • 01:52 — Intro • 02:59 — Is Aging Optional for Your Scalp? • 04:03 — Understanding Scalp and Hair Aging • 05:06 — The Role of Senescent Cells in Hair Loss • 07:25 — Hormonal Influences on Hair Health • 16:10 — Peptide Solutions for Hair Thinning • 18:05 — Clinical Studies and Results • 20:29 — Future of Hair Loss Treatments • 30:16 — Nutritional and Lifestyle Factors • 36:40 — Addressing Senescent Cells and Hair Growth • 37:29 — Minoxidil: Oral vs. Topical Use • 39:32 — Personal Experience with Hair Products • 40:25 — Combining Therapies for Hair Growth • 46:06 — Nutritional Factors in Hair Health • 52:20 — Sun Exposure and Hair Health • 56:40 — Coffee and Hair Growth • 01:00:01 — Launching the New Hair Product See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 11 April 2025

What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs. Joining him is award-winning journalist from The Atlantic, Olga Khazan, author of Me, But Better, who spent years hacking her own mind—transforming high neuroticism, social avoidance, and chronic self-criticism into calm, confidence, and connection. Her personal experiment in identity rewiring became a roadmap for anyone who wants to feel different… and live differently. You’ll uncover the hidden mechanisms behind neuroticism, reactivity, and emotional spirals—and how to override them with real-time upgrades.  What You’ll Learn in This Episode: • Why your personality is a program—and how to recode it • What daily behaviors scientifically rewire anxiety, anger, and reactivity • The surprising link between identity, inflammation, and your gut • Why gratitude isn’t soft—it’s neurological jiu-jitsu • How to know if it’s your biology or your story running the show • Whether pills, psychedelics, or sleep do more to shift who you are • What to do when your inner critic won’t shut up • And how to stop being the person you never meant to become  SPONSORS -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.  -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  Resources:  • Olga’s New Book – Me, But Better: https://www.amazon.com/Me-But-Better-Science-Personality/dp/1668012545 • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Olga's Instagram –  https://www.instagram.com/olganator/?hl=en • Olga’s Website: https://olgakhazan.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com   Timestamps: • 0:00 — Trailer • 1:52 — Intro • 2:16 — Personality Changes and Neuroticism • 5:38 — Postpartum Personality Shifts • 10:21 — Gratitude and Cultural Beliefs • 18:13 — Anger Management and Empathy • 32:58 — Personality Traits and Boundaries • 35:46 — The Importance of Strong Boundaries • 36:07 — Personality Change as Self-Improvement • 37:22 — The Role of Medication in Personality Change • 39:18 — Brain-Body Connection and Mental Health • 43:26 — Impact of Sleep and Nutrition on Personality • 44:23 — Nicotine and Other Substances • 45:41 — Therapy and Personality Change • 46:43 — Changing Personality Through Behavior • 1:01:25 — The Role of Relationships in Personality Development • 1:04:49 — Challenges and Methods in Personality Change • 1:08:38 — The Power of Improv in Personality Change • 1:10:17 — Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 10 April 2025

Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter, founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization—no substances, no side effects, no BS. Dr. Porter breaks down how to activate gamma brainwaves, repair trauma loops, access psychedelic-like states, and boost cognitive performance by 19% in just six weeks. You’ll learn why most brains burn out decades too soon—and how to charge yours back up.  What You’ll Learn in This Episode: • How to flood your brain with energy and wake it up • The light and sound protocol that mimics psychedelics—safely • What gamma brainwaves unlock—and how to generate them on demand • Why your default mode network traps you in stress and distraction • The BrainTap protocol that improved cognition by 19% in 6 weeks • A real-life transformation story that rewrote one woman’s fate • The link between sleep, trauma, brain states, and performance • How to build a brain that performs like it’s decades younger  This episode gives you a playbook to reclaim your focus, deepen your rest, and experience the full range of human consciousness—without touching a drug. Turn your brain on. Then turn it up.  SPONSORS -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.  -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.  Resources:  • Biohacking Conference 2025 (May 28th-30th in Austin): https://biohackingconference.com/2025 (use code BRAINTAP to save 30% on General Admission and Virtual Tickets)• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • BrainTap Instagram: https://www.instagram.com/braintaptech/?hl=en • BrainTap Website: https://braintap.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 00:35 – Intro • 00:50 – Meet Dr. Patrick K. Porter and BrainTap • 01:28 – The Science Behind Light and Sound Therapy • 03:38 – Quantum Biology and Frequency Medicine • 04:32 – Enhancing Cognition with Sound and Light • 06:19 – Biohacking Conference Highlights • 08:07 – Transformative Stories and BrainTap Benefits • 17:54 – The Role of Gamma Waves and Psychedelics • 26:55 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 8 April 2025

You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable.  It feels like love.  But what if it’s making them weak?  In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history—Gen Z. Whether you’re raising kids, managing young employees, or trying to understand the next generation—you’ll walk away from this episode with a new lens on resilience, responsibility, and real-world readiness.  What You’ll Learn in This Episode: • Why Gen Z struggles with anxiety, confidence, and failure • How smartphones, safe spaces, and overparenting weaken resilience • The science behind boredom, chores, and grit-building discomfort • Why participation trophies are doing real psychological harm • The bold parenting shifts that build strong, adaptable adults • How to model strength—even when it’s unpopular • The simple framework to raise kids who can thrive, not just survive  If you want to raise strong kids—or work with a generation that’s struggling—this episode is a must-listen. It’s not just about parenting. It’s about the future. And it starts with getting uncomfortable.  SPONSORS -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions.  Resources:  • A Day of Biohacking and Consciousness Even (4/12): https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Jennifer’s Instagram: https://www.instagram.com/therealjencohen/ • Jennifer’s Podcast: https://www.youtube.com/channel/UCBuPgI8lXTmy5T0D_EDMnVg • Jennifer’s Website: https://www.jennifercohen.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 01:59 – Intro • 03:38 – The Shift in Parenting Styles • 07:04 – The Role of Technology and Social Media • 10:59 – The Importance of Failure and Resilience • 13:38 – Practical Parenting Tips and Challenges • 24:06 – The Value of Chores and Responsibility • 26:24 – Balancing Luxury and Adversity in Parenting • 27:01 – Teaching Kids to Embrace Failure • 28:00 – The 10% Target: Encouraging Persistence • 29:35 – The Importance of Boredom and Creativity • 30:58 – Role Modeling Healthy Habits • 31:43 – Kids’ Reactions to Fast Food • 32:49 – Extreme Parenting: Biohacking and Kids • 36:30 – Rejection Therapy and Boldness • 42:42 – Praising Effort Over Intelligence • 45:32 – Challenges of Being Attractive and Intelligent • 49:31 – Instilling Self-Esteem in Children • 50:13 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 3 April 2025

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging? In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism. You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory. So what’s the one upgrade that can actually reset your gut… for good? What You’ll Learn in This Episode: • Why your gut—not your brain—is making most of your decisions • How 93% of probiotics on the market fail before they reach your intestines • The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO • What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it) • The shocking gut–brain–heart axis connection you’ve never heard of • Why inflammation, brain fog, and mood swings may start with leaky gut • Which probiotic strains are clinically proven to improve cognition and mood • What to do if you want to eat gluten again—or survive American wheat • How a fermented papaya concentrate could replace your acid reflux meds • Why optimizing your gut could extend your lifespan by 40%  ***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***  SPONSORS -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • OMNi-BiOTiC's Instagram –  https://www.instagram.com/fatty15/ • OMNi-BiOTiC's Website: https://omnibioticlife.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 03:15 – Intro • 05:05 – Probiotics, Prebiotics, and Postbiotics Explained • 08:21 – The Importance of Delivery Mechanisms • 17:36 – Addressing SIBO and Gut Health Protocols • 31:55 – The Impact of GLP-1 Drugs on Gut Health • 39:26 – The Role of Gut Bacteria in Hunger and Fasting • 40:01 – Painkillers and Gut Health: A Personal Experience • 40:51 – The Dangers of Proton Pump Inhibitors • 42:00 – The Importance of Stomach Acid • 44:55 – Probiotics for Chronic Conditions • 48:38 – The Impact of Glyphosate on Gut Health • 57:04 – Alcohol and Gut Bacteria • 01:02:01 – New Solutions for Acid Reflux • 01:07:57 – The Future of Gut Health and Longevity • 01:11:33 – Conclusion and Special Offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 1 April 2025

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?  Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15, that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place—U.S. Navy dolphins that were outliving their wild counterparts by decades—this forgotten fat is now shaking up the scientific community.  So why hasn’t anyone told you about it?? Decades of misguided dietary advice stripped this crucial nutrient from our food system, leaving an entire generation unknowingly deficient. Even worse, pregnant women have been some of the MOST hurt from this cruel change to our modern diet. Now, cutting-edge research is proving that C15 plays a critical role in cellular stability, mitochondrial function, and total mental health.  What You’ll Learn in This Episode: • The first new essential fatty acid discovered in nearly 100 years—and why it matters • How dolphins led to one of the BIGGEST breakthroughs in human nutrition • Why the removal of C15 from our diets is accelerating aging • The surprising connection between C15 and mental health • How this “missing” fat could outperform some of the biggest longevity drugs today! • What foods naturally contain C15—and should you supplement it?  *** Get 15$ off Fatty15 at www.fatty15.com with code: DAVE ***  SPONSORS Puori | Visit https://puori.com/dave and use code DAVE for 20% off.Calroy | Head to https://calroy.com/dave for an exclusive discount.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Fatty15 Instagram – https://www.instagram.com/fatty15/ • Fatty15 Website: www.fatty15.com • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 – Intro 00:34 – Meet Dr. Stephanie Venn-Watson 00:46 – Discovering C15 in Navy Dolphins 01:58 – Challenges and Skepticism 04:21 – Scientific Validation and Research 06:59 – C15’s Impact on Human Health 27:43 – Big Data, AI, and Longevity Research 36:08 – C15 as a Longevity Nutrient 42:14 – The Navy’s Role in Fatty 15 43:03 – Epigenetic Aging and Lifespan 44:51 – Nutritional Guidelines and C15 Deficiency 50:41 – Mental Health and Endocannabinoids 51:33 – Dairy, Fats, and Nutrition History 56:38 – Fatty 15 in Skincare and Supplements 01:03:58 – Regulatory Changes in Nutrition 01:11:26 – Gender Differences in Fatty Acids See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 27 March 2025

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself? In this episode, Columbia University psychiatrist and nutritional neuroscience pioneer Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain. You’ll explore the cutting-edge science of neuroplasticity, discover how movement and social connection trigger brain growth, and learn why food is still your most powerful antidepressant. Plus: dancing, psychedelics, kale debates, and why porn is quietly reshaping the male brain.  What You’ll Discover in This Episode: • Why brain fog, anxiety, and mood swings might be signs your brain is inflamed • How movement—especially dancing—can literally help your brain grow stronger • What your gut has to do with your mental health (and why some “healthy” foods can backfire) • The truth about antidepressants, supplements, and why there’s no one-size-fits-all fix • Why porn, ultra-processed food, and doomscrolling are silently wrecking focus and drive • A new way to think about mental fitness—like a workout plan for your brain  SPONSORS -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.  -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.   Resources:  • A Day of Biohacking and Consciousness Event April 12th: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Drew’s Instagram: https://www.instagram.com/drewramseymd/?hl=en • Drew’s Linktree: https://shorturl.at/CIIR5 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 01:43 – Intro • 02:51 – The State of Mental Health Today • 04:00 – Nutritional Psychiatry and Personal Experiences • 05:21 – Environmental Factors and Brain Health • 05:55 – Chemical Balance and Psychiatry • 09:19 – Mental Fitness and Connection • 14:17 – Modern Brain Challenges • 16:26 – The Role of Movement and Dance • 22:44 – Sex, Relationships, and Mental Health • 34:02 – Microbiome and Mental Health • 36:50 – Transitioning to Urban Life and Mental Health • 37:29 – The Role of Nature in Mental Well-being • 38:14 – Personal Experiences with Gut Health • 39:45 – Trial and Error in Mental Health • 42:16 – Cognitive Resilience and High Performance • 45:37 – The Importance of Family Meals • 46:33 – Challenges of Rural and Urban Living • 47:53 – Brain Health: Beyond Neurons • 49:01 – Neuroplasticity and Mental Fitness • 52:50 – Biohacking Mental Health • 57:31 – The Role of Serotonin in Depression • 01:03:57 – Debating the Benefits of Kale • 01:12:03 – Final Thoughts on Mental Health and Resilience See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 25 March 2025

You think, you feel, you are—but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical? In this episode, Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey to challenge everything you think you know about the mind, reality, and human potential. He explores groundbreaking research on near-death experiences, psychic phenomena, and why some scientists believe consciousness may exist beyond the body. Mark reveals how declassified CIA documents, quantum physics, and meditation practices point to a deeper, more interconnected world—one where perception creates reality. If you’ve ever questioned whether free will is an illusion, wondered about life after death, or wanted to tap into higher states of awareness, this episode will shift your perspective.  What You’ll Discover in This Episode: • Is consciousness non-local? Why your brain might not be the source of your thoughts • Near-death experiences & life after death—the science and firsthand accounts • Psychic phenomena & remote viewing—what the CIA doesn’t want you to ignore • Float tanks, meditation & altered states—how to access expanded awareness • The AI consciousness debate—can machines ever become truly self-aware? • Protecting your energy—why spiritual safeguards matter when exploring altered states  SPONSORS -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.   Resources:  • A Day of Biohacking and Consciousness Event April 12th: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mark’s Instagram: https://www.instagram.com/markgober_author/ • Mark’s Website: https://www.markgober.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 - Trailer 00:50 - Intro 03:11 - Meet Mark Gober 05:25 - From Banking to Awakening 10:16 - Float Tanks & Consciousness 12:35 - Psychic Phenomena 19:14 - Science & Skepticism 25:51 - Personal Experiences 40:51 - Spiritual Protection 42:58 - Parasitic Entities 44:59 - Psychedelics & Mindset 45:58 - Alien Abductions 47:04 - Navigating Psychedelics 51:58 - Intuition & Inner Knowing 58:41 - Telepathy & Remote Viewing 59:46 - Near-Death Experiences 01:04:54 - Consciousness Beyond the Brain 01:12:38 - Psychic Abilities & Ethics 01:24:11 - Consciousness & Reality 01:27:58 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 20 March 2025

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize? In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets. He reveals how toxic altruism, external validation, and emotional fragility keep people stuck—and how you can reclaim your confidence, set boundaries, and create a life of true growth. Dr. Kaufman, one of the world’s most cited scientists, shares cutting-edge research on self-actualization, resilience, and the hidden mental loops that shape your success. If you’ve ever felt stuck in self-doubt, drained from over-giving, or afraid to take up space, this conversation will help you break free.  What You’ll Discover in This Episode: • Victim vs. empowerment mindset—the key shift that changes everything • The psychological traps of toxic altruism—and why over-giving holds you back • How people-pleasing rewires your brain—and how to break the cycle • The science of self-actualization—how to unlock your full potential without guilt • Why modern culture and social media reward emotional fragility—and how to rise above it • The neuroscience behind confidence, resilience, and making better choices for YOUR growth  If you’ve ever felt stuck, undervalued, or drained from always being “nice”, this episode will show you how to step into your power, rewrite your mental programming, and take control of your future.  SPONSORS -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Resources:  • A Day of Biohacking and Consciousness Event: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Scott’s Instagram: https://www.instagram.com/scottbarrykaufman/?hl=en • Scott's New Book – Rise Above:https://scottbarrykaufman.com/books/rise-above/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 Trailer • 00:44 Intro  • 02:02 Rise Above – Scott’s New Book • 03:13 Triggers and Mind Control • 05:12 Victimhood and Self-Actualization • 12:01 Curiosity Over Fear • 16:32 The Power of Discernment • 26:32 Emotional Resilience Today • 31:12 The Fragility of Younger Generations • 37:33 Social Pressures and Identity • 39:47 Social Media and Self-Determination • 40:35 Community and Belonging • 42:42 Activating Happiness and Growth • 44:43 Gratitude and Daily Practices • 51:48 Healthy Selfishness vs. Altruism • 58:56 Codependency and Vulnerable Narcissism • 01:04:57 The Dark Triad and Personality Types • 01:09:14 Final Thoughts and Book Recs See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 18 March 2025

                                                                                                                                                                             What do vibrations and the psychedelic experience have in common? MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug? It turns out your brain responds to more than just chemistry. Vibration, frequency, and rhythm have been shaping human consciousness for millennia—from ancient chanting rituals to modern neuroscience breakthroughs. Could the right vibrations unlock the same neuroplasticity and healing pathways as psychedelics? In this episode, Dave Asprey sits down with Dr. Dave Rabin, a neuroscientist, psychiatrist, and psychedelic researcher, to explore how vibrations can rewire your brain, enhance neuroplasticity, and even mimic the effects of MDMA therapy. Dr. Rabin’s work led to the creation of Apollo Neuro, a wearable device that taps into your nervous system’s natural ability to regulate stress, boost focus, and accelerate recovery—without pharmaceuticals.  What You’ll Discover in This Episode: • How specific vibrations trigger deep relaxation and neuroplasticity • Why MDMA therapy works—and how vibration-based tech can simulate it • The surprising science behind music, frequency, and altered states • How Apollo Neuro enhances sleep, focus, and emotional resilience • The overlooked role of heart rate variability in longevity and health • Why stress is the biggest obstacle to healing—and how to override it  **Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%**  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Apollo Neuro Instagram: https://www.instagram.com/apolloneuro/?hl=en • Apollo Neuro Website: https://apolloneuro.com/Dave • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 Trailer 00:40 Intro 01:18 Exploring Vibration in Biohacking 02:29 Introduction of Dr. Dave Rabin 02:53 Understanding Vibration and Its Impact 04:47 The Apollo Neuro Device 08:44 Using Apollo for Different States 11:41 Apollo in Psychedelic Therapy 24:32 Clinical Trials and Studies on Apollo 29:32 Heart Rate Variability and Biohacking 33:02 Revolutionizing Sleep with Apollo 34:40 Apollo’s Long-Term Effects and Dependency 37:16 Apollo’s Impact on ADHD and Psychiatric Disorders 45:22 The Importance of Human Connection and Simple Solutions 49:56 Longevity, Healthspan, and Future Innovations 57:23 Final Thoughts and Discount Offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 14 March 2025

Your Brain is Lying to You—Here’s How to Take Back Control Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you? In this episode, Bizzie Gold, mind architect and creator of The Break Method, joins Dave Asprey to expose the self-deception patterns controlling your thoughts—and how to reprogram your brain for true transformation. Bizzie’s method isn’t just another self-help philosophy. It’s science-backed, no BS, and engineered for results. From subconscious conditioning to emotional addiction cycles, you’ll learn the exact framework for breaking free from limiting beliefs and upgrading your mind. What You’ll Discover in This Episode: • The hidden mental loops sabotaging your success (and how to break them) • The science of self-deception—why your brain lies to you daily • How early childhood experiences hardwire your thoughts and emotions • The brain’s rejection vs. abandonment patterns—which one rules you • How to use E.L.I. questions to disrupt negative thinking instantly • The AI-powered brain upgrade that could change self-improvement forever If you’ve ever felt stuck in repetitive thought patterns, bad habits, or emotional cycles, this episode will give you the blueprint to take back control of your mind. Listen now—because your brain won’t fix itself.  SPONSORS -Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off.  -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Bizzie Gold’s Instagram: https://www.instagram.com/bizziegold/ • Bizzie Gold's Website: https://bizziegold.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Trailer • 00:28 – Intro • 01:39 – Understanding self-deception and its impact • 05:41 – The role of childhood trauma in shaping perception • 14:20 – Brain pattern spectrum and human behavior • 22:26 – Spiritual perspectives on DNA and past lives • 34:45 – Sharing knowledge from the ether • 34:54 – A surprising encounter with a professor • 35:43 – Healing and accessing intuition • 36:39 – The power of intuition in practice • 38:15 – Spiritual technology and Big Pharma • 39:54 – The role of self-trust in intuition • 40:49 – Understanding instinct vs. intuition • 42:17 – The E.L.I. framework for intuition • 45:50 – Hacking the brain’s language system • 57:04 – Parenting for emotional resilience • 01:06:13 – AI and emotional hacking • 01:11:01 – Conclusion and final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 13 March 2025

Is the Way You Speak Limiting How You Think?For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations.In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and even consciousness.If language rewires thought, what happens when AI starts using it? Can a machine truly think? And what if whales, with their massive brains, have a language of their own?What You’ll Discover in This Episode: • The hidden power of language—why learning a new one literally reshapes your brain • The Piraha people’s mind-blowing approach to communication and what it reveals about human thought • Can AI truly “think” in language, or is it just an advanced mimic? • How your environment affects memory, navigation, and cognitive function • The psychedelic connection to language evolution—could altered states have unlocked speech?  SPONSORS• Puori | Visit https://puori.com/dave and use code DAVE for 20% off.• BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Resources:• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/• Dan Everett’s Website: https://daneverettbooks.com/• 2025 Biohacking Conference: https://biohackingconference.com/2025• Danger Coffee: https://dangercoffee.com• Dave Asprey’s Website: https://daveasprey.com• Dave Asprey’s Linktree: https://linktr.ee/daveasprey• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com• Own an Upgrade Labs: https://ownanupgradelabs.com• Upgrade Labs: https://upgradelabs.com• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 11 March 2025

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease. Forget the old-school genetic reports that left you with useless percentages. The new frontier of precision genomics goes beyond risk factors to actionable insights, showing you exactly how to turn on your body’s most powerful longevity genes and turn off the pathways driving inflammation, cognitive decline, and disease.  What You’ll Learn in This Episode: • Why genetics alone don’t determine your future—and how to use epigenetics to control your health • The truth about MTHFR, APOE4, and other “bad” genes—are they actually harming you? • How genetic reports can predict and eliminate brain fog, fatigue, and pain • The hidden genetic reasons behind ADHD, depression, and anxiety—and how to fix them • Why some people age faster—and the one longevity gene that determines your biological age • Cutting-edge breakthroughs in DNA-based biohacking—is it possible to edit your genes for peak performance?  This is the future of personalized medicine. By understanding your own genetic blueprint, you can stop guessing and start making the precise changes that will optimize your energy, brainpower, and lifespan!  ** Visit IntellxxDNA at https://intellxxdna.com/asprey/ When you go to the website to find a clinician please select “human upgrade/longevity” as the type of consult to get specialized biohacking clinicians! **  SPONSORS -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • IntellxxDNA Website: https://intellxxdna.com/asprey/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Intro • 02:00 – The Role of Genetics in Longevity • 03:37 – Gene Variants & Cognitive Health • 05:58 – Epigenetics vs. Genetics • 08:21 – Genomics & Pain Management • 09:26 – Breakthroughs in Genetic Research • 12:33 – The Future of Genomic Medicine • 14:27 – How to Use Genomic Reports • 38:25 – Mitochondria & Longevity • 42:40 – BH4 & Mental Health • 43:42 – Folinic Acid & Brain Function • 44:37 – Genomics & Autism • 46:06 – Personalized Medicine • 56:00 – APOE4 & Alzheimer’s Risk • 59:44 – Genetics & Heart Health • 01:04:54 – The Future of Precision Medicine • 01:20:23 – Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 6 March 2025

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion! In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind Tiny Habits, explains why motivation, ability, and the right prompts are the real drivers of habits. Meanwhile, Atomic Habits author James Clear reveals how small decisions compound over time to shape your entire life.  What You’ll Learn in This Episode: • Why willpower and repetition don’t work—and what actually makes habits stick • The tiny changes that create massive, lasting results • How emotions play a bigger role in habit formation than you think • The hidden power of stacking small habits for exponential growth • How to automate your decisions to free up brainpower for bigger goals  SPONSORS -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • BJ Fogg’s Website –  https://www.bjfogg.com/ • James Clear’s Website: https://jamesclear.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com   Timestamps: • 00:00 – Intro  • 00:39 – Understanding habits • 01:10 – Layering habits with James Clear • 01:49 – BJ Fogg’s Tiny Habits method • 03:03 – The science of habit formation • 05:49 – Practical habit-building tips • 09:57 – Emotions vs. repetition in habits • 18:02 – Ability & context in habits • 21:19 – Genes, dopamine & behavior • 26:20 – Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 5 March 2025

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there!  What You’ll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave’s personal take • How mitochondria impact brain power, mood, and aging—and how to fix them today! • The shocking reason some people can’t process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting  SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  -Calroy | Head to https://calroy.com/dave for an exclusive discount.  Resources:  • Upgrade Collective Membership: https://www.ourupgradecollective.com • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger’s Syndrome and Neuroinflammation • 28:53 – Understanding Asperger’s and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 27 February 2025

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating.  What You’ll Learn: • The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn’t want you to know about this breakthrough  *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE ***  Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram:  https://www.instagram.com/mimiohealth/ • Mimio Website:  https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio’s Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 25 February 2025

Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andy Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer.  What You’ll Learn: • The #1 reason your NAD is disappearing—and how to fix it • Why NAD is the missing link in energy, DNA repair, and disease prevention • The hidden enzyme (CD38) that’s sabotaging your longevity • How to supercharge mitochondria, optimize blood flow, and fight aging at the source • Why the supplement industry has it wrong—and the best way to boost NAD naturally • The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine  Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Andrew Salzman’s Instagram –  https://www.instagram.com/andrew_salzman/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  Timestamps: 00:00 Trailer 01:07 Introduction and Episode Overview 02:29 Meet Dr. Andy Salzman 02:36 From Physician to Researcher 03:39 Pharmaceuticals vs. Nutritionals 04:17 The Role of NAD in Longevity 06:32 Challenges in Longevity Research 12:58 Understanding NAD and PARP 14:34 NAD’s Impact on Health 23:19 Gut Health and Longevity 27:43 Innovations in NAD Supplementation 41:27 Customer Feedback and Product Effectiveness 42:41 Surprising Benefits of NAD for Sexual Health 44:47 NAD and Vascular Health 48:46 NAD’s Role in Aging and Longevity 54:03 NAD and Lifestyle Choices 01:03:02 NAD and Cognitive Function 01:06:18 NAD and Exercise 01:13:42 NAD and Sleep 01:21:54 Final Thoughts on NAD and Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 21 February 2025

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity.  What You’ll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can’t gain fat • How to tell if insulin resistance is wrecking your energy & health   Resources:  • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ •  Benjamin’s new book How Not To Get Sick :  https://a.co/d/aADlMWv • Benjamin’s YouTube Page –  https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 20 February 2025

Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. Dave and Rick go deep on the mental and physiological hacks that enhance creative performance, the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. What You’ll Learn: • How Rick Rubin taps into creative flow—and how you can too • The surprising connection between meditation and peak artistic performance • Why biohacking isn’t just for longevity—it’s for creative mastery • Rick’s favorite tools for mental clarity, focus, and creative breakthroughs • The real secret behind working with the world’s biggest artists • How to cultivate an environment that fuels creativity  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS   • Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off.  BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.  Timestamps: • 00:00 – Trailer • 00:51 – Intro to Rick Rubin • 02:51 – Rick’s Musical Journey • 03:06 – The Creative Process • 08:31 – Biohacking & Sensitivity • 13:46 – Meditation & Creativity • 19:37 – Rick’s Weight Loss Story • 29:21 – Eating Habits & Rhythm • 29:55 – Advanced Biohacking • 31:23 – Oxygen Therapy & Carbogen • 35:16 – Peptides & Longevity • 45:59 – Prayer, Gratitude & Performance • 51:03 – Reflections on Life & Mortality See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 18 February 2025

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity, this episode will shift the way you think about money, health, and success. Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through?  What You’ll Learn: • The biggest mistake people make with money (and how to avoid it) • The mindset of the ultra-wealthy—how top investors think differently • Why fear is your greatest enemy in investing and personal success • The three essential money buckets—security, growth, and dreams • Tony’s top biohacks for insane energy and peak performance • The real secret to happiness and fulfillment (it’s not what you think)  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Tony’s Website: https://www.tonyrobbins.com/ • Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  Timestamps: • 00:00 Intro • 00:50 Meet Tony Robbins • 02:18 Financial Wisdom & Motivation • 05:43 Psychology of Wealth • 10:10 Investment Strategies • 15:24 Balancing Money & Experiences • 21:21 Power of Giving • 30:06 Paying for College • 31:00 Commitment & Success • 31:53 Energy & Biohacks • 35:12 Cryotherapy & Inflammation • 38:54 Stem Cells & Regeneration • 41:59 Financial Freedom • 46:35 Wnt Pathway Breakthroughs • 52:35 Health & Longevity • 56:34 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 13 February 2025

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of quick fixes, and the hard truths about personal transformation. Timbaland opens up about the mental shift that saved his life, how he kicked a high-dose opioid habit cold turkey, and why his new “drug” of choice is something anyone can access. Most people want change, but few actually achieve it. What separates those who succeed from those who stay stuck? And how can you apply Timbaland’s hard-earned lessons to your own life? What You’ll Learn: • The #1 mindset shift that made weight loss & addiction recovery possible • Why self-discipline beats willpower—and how to build it like a muscle • The real reason most diets fail—and what actually works • The truth about opioid addiction and recovery—why most people never escape • How your daily habits shape your future—and how to change them fast • The shocking link between addiction, metabolism & long-term health • How Timbaland stayed clean without rehab—and why relapse wasn’t an option  We’d like to extend our gratitude to Eudēmonia for providing the opportunity to record with Timbaland at their event. Eudēmonia, created by the founders of Wanderlust Festival, is a premier health and well-being summit. You can learn more about their initiatives and upcoming events here: https://wanderlust.com/  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Timbaland’s Website: https://www.timbaland.com/ • Timbaland’s Instagram : https://www.instagram.com/timbaland/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  -STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order.  -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  Timestamps: • 00:00 Trailer • 00:00 Introduction to the Human Upgrade • 00:09 Timbaland on Passion and Energy • 00:42 Balancing Passion and Avoiding Burnout • 02:04 Dreams and Manifestations • 04:51 Overcoming Addiction • 05:59 The Role of God in Recovery • 09:28 Helping Others with Addiction • 14:00 Weight Loss and Health Transformation • 16:29 Trusting Your Body’s Signals • 18:45 Skepticism About Modern Products • 21:10 Exploring Longevity and Individual Health • 22:23 The Intersection of Music and Spirituality • 25:56 Understanding Synesthesia and Its Impact • 27:41 The Journey to Weight Loss and Fitness • 35:08 The Importance of Sleep and Health • 37:23 Final Thoughts and Reflections See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 11 February 2025

Could the right form of a single vitamin be the difference between thriving and barely surviving? In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn’t talking about this critical health breakthrough. Are you unknowingly setting yourself up for disease? What’s the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity?  What You’ll Learn: • The MTHFR gene mutation—and why it’s quietly affecting millions • Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain • The gut-brain connection—how your microbiome controls your mood • Why your “healthy diet” might be hurting you (and what to eat instead) • How nutrient deficiencies are passed from mother to child—and how to stop it • The truth about homocysteine—the blood marker that could predict your lifespan • Why most people are living at 50% capacity—and how to get your energy back  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Gary Brecka’s Website: https://bit.ly/4hlfyti • Gary Brecka’s YouTube: https://bit.ly/3E3Aaba • Gary Brecka’s Instagram: https://bit.ly/3PNsgFe • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com • The Mold Movie!: https://moldymovie.com/  SPONSORS:  -BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.  -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions.  Timestamps:  • 00:00 Trailer  • 00:31 What Is Methylation?  • 01:37 MTHFR, Folate & Your Health  • 04:17 How Methylation Affects Disease  • 06:41 Nutrient Deficiencies & Health Risks  • 07:09 Why Blood Work Matters  • 11:44 Homocysteine & Heart Health  • 21:37 Catecholamines & Anxiety  • 34:28 The Link Between Nutrients & Mood  • 34:48 How Catecholamine Ratios Affect Mental Health  • 35:39 Personal Health Struggles & Lessons  • 36:25 The Role of Methylation in Wellness  • 37:57 Methylation & Relationship Dynamics  • 39:49 Hidden Dangers of Mold Toxicity  • 52:55 Hydrogen Water for Health  • 01:01:19 Mitochondria’s Role in Longevity  • 01:02:23 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 6 February 2025

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the corporate greed, medical corruption, and environmental toxins designed to keep you sick, weak, and dependent. What’s really causing the testosterone collapse in men and women? How is AI changing the game for hormone optimization, biohacking, and personalized health? And why are we aging faster than ever—while Big Pharma profits? This first episode in a two-part series is a deep dive into hormone optimization, testosterone, cholesterol myths, longevity hacks, and the AI-driven future of health.   What You’ll Learn: • Why testosterone levels are plummeting—and how to restore them naturally • The real reason life expectancy is dropping (hint: it’s not just diet) • The Kellogg conspiracy—how food was designed to lower libido & testosterone • Why mainstream medicine is failing you (and what to do instead) • How AI and big data are rewriting the rules of health & longevity in• The shocking truth about cholesterol, heart disease, and pharmaceuticals • Why functional medicine & biohacking hold the key to real health optimization  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Gary Brecka’s Website: https://bit.ly/4hlfyti • Gary Brecka’s YouTube: https://bit.ly/3E3Aaba • Gary Brecka’s Instagram: https://bit.ly/3PNsgFe • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%.  Timestamps: • 00:00 – Trailer • 00:42 – Introduction to The Human Upgrade • 01:35 – Meet Gary Brecka • 03:32 – Performance vs. Longevity • 06:16 – The Importance of Testosterone • 15:11 – Historical Hormone Levels • 18:00 – Population Averages in Health • 18:51 – The Flaws of Grading on a Curve • 20:35 – Corporate Influence on Health • 21:04 – The Danger of Cumulative Dosage • 22:20 – Social Media & Public Perception • 25:19 – Independent Research Matters • 32:21 – Big Data & AI in Health • 36:02 – The Future of Personalized Medicine • 36:49 – Conclusion & Teaser for Part Two See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 5 February 2025

Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, and reality. What if the Great Pyramid wasn’t just a monument but a powerful energy device designed to amplify human potential? What if ancient civilizations understood frequency, grounding, and longevity in ways modern science is only beginning to grasp? In this episode, the Carsons connect the dots between lost technology, bioenergetics, and conscious relationships, showing how these ancient systems align with the latest research on vibrational healing, mitochondrial energy, and peak performance. They explore how quantum fields influence cellular regeneration, why high-frequency living affects health and relationships, and how suppressed knowledge could redefine the future of wellness. What You’ll Learn: • How the Great Pyramid functioned as an energy generator—and how to apply its principles to longevity • The forgotten science of frequency and its effects on health, aging, and vitality • How quantum energy and grounding can optimize mitochondrial function • The connection between biohacking, consciousness, and relationships • Why suppressed ancient knowledge holds the key to true human potential  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 •  4biddenknowledge YouTube – https://www.youtube.com/@ForbiddenKnowledge1 •  4biddenknowledge Website – https://www.4biddenknowledge.com/ •  Billy Carson Instagram – https://www.instagram.com/4biddenknowledge/?hl=en •  Elisabeth Carson Instagram - https://www.instagram.com/elisabethicarson/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  Timestamps:  • 00:00 Trailer  • 00:39 Meet Dave Asprey  • 02:16 Trauma, Success & Relationships  • 04:22 Billy & Elizabeth Carson on Growth  • 10:09 Birth & Pre-Natal Trauma  • 19:30 Healing & Biohacking  • 23:16 Relationships & Triggers  • 28:35 Vitamin D & Nutrients  • 35:25 Empathy & Intuition  • 37:24 Manifestation  • 41:25 Neuroscience & Altered States  • 53:04 Ancient Wisdom & Biohacking  • 57:45 Ancient Technologies  • 01:08:26 Giants & Six Fingers  • 01:08:58 Sumerian Artifacts  • 01:10:28 Hidden Agendas  • 01:13:32 Hypnosis Revelations  • 01:19:21 Power of Intuition  • 01:30:11 Love & Self-Discovery  • 01:35:52 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 30 January 2025

Everything you’ve been told about weight loss is a lie!In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health. Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional dieting often fails—and what actually works. From the role of ketosis in healing chronic illness to the surprising ways fasting affects hair loss, metabolism, and inflammation, this episode is packed with actionable insights that you won’t hear anywhere else. You’ll also learn how viruses might be fueling food addiction, why gut health is the missing key to metabolic recovery, and how new research could unlock the future of personalized medicine. If you’ve ever felt like your metabolism was holding you back, this conversation will give you the tools to take control of your health for good. What You’ll Learn:  • Why calorie counting is useless—and the better way to lose weight  • The shocking truth about how your metabolism ACTUALLY works  • How ketosis and fasting can heal inflammation and chronic disease  • The role of gut health and microbiome diversity in weight loss  • New research on food addiction and its surprising link to viruses  • Why individualization is the key to sustainable health  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Nick Norwitz’s YouTube – https://www.youtube.com/@nicknorwitzPhD • Nick Norwitz’s Website – https://www.nicknorwitz.com/ • Follow Nick on Instagram – https://www.instagram.com/nicknorwitz/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  Timestamps: • 00:00 Trailer • 00:39 Meet Dr. Nick • 04:44 Nick’s Health Journey • 07:54 Keto Diets • 09:37 Modern Medicine Challenges • 13:31 Exercise vs. Diet • 14:32 Obesity Memory • 17:36 Keto Cycling • 20:51 Microbiome Health • 26:26 Fasting & Hair Loss • 34:56 Alzheimer’s Insights • 45:11 Cold Plunge Benefits • 45:43 Dopamine Boosts • 46:26 Cold Plunge & Inflammation • 47:15 Best Time to Cold Plunge • 48:18 Pain & Dopamine • 49:31 Exercise & Stress • 51:49 Cholesterol & Inflammation • 01:05:42 Debunking Calories In/Out • 01:07:09 Food Addiction • 01:11:15 Metabolic Health Tips • 01:24:13 Nick’s Mission See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 28 January 2025

What if the key to living longer isn’t avoiding stress—but mastering it Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancient practices that have stood the test of time, Jeff shares how to unlock the hidden potential of stress to build resilience, foster connections, and boost longevity. You’ll discover why crying is an emotional biohack, how to spot the fine line between good and bad stress, and why the modern world keeps us stuck in a chronic stress loop—and how to break free. Jeff also dives into the science of emotional regulation, the role of connection in health, and the radical power of embracing discomfort to create balance and ease in your life. What You’ll Learn:  • How to turn stress into a tool for resilience and longevity  • Why Jeff calls chronic ease the root of modern disease  • The science of tears: how crying regulates stress and boosts health  • How you can build a “psychological immune system” for emotional regulation  • The key to balancing good stress and avoiding burnout  • Why discomfort is the path to growth—and how to embrace it  Resources:  • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Jeff Krasno’s Website – https://www.jeffkrasno.com/ • Preorder Good Stress – https://www.onecommune.com/goodstressbook#preorder • Follow Jeff on Instagram – https://www.instagram.com/jeffkrasno • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.  Timestamps: • 00:00 – Intro • 01:02 – Meet Jeff Krasno • 02:16 – Topanga Fires Survival • 04:14 – Good Stress vs. Bad Stress • 06:14 – Cortisol’s Role in Stress • 13:13 – Social Media Triggers • 20:32 – Stressful Conversations • 31:34 – Cold Therapy Benefits • 42:26 – Stress and Recovery Balance • 45:58 – High Altitude Training • 47:29 – Cold Therapy Fails • 49:42 – Science of Crying • 54:51 – Reflections on Legacy • 59:37 – Balancing Stress and Ease • 01:10:30 – Nature and Spirituality • 01:22:52 – Facing Death with Grace • 01:32:53 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 23 January 2025

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level. What You’ll Learn: • The Seven Tenets of Aging and how they’ll change your approach to health • Why indulging in “bad” habits doesn’t have to sabotage your longevity • Biochemical secrets to combat oxidative stress, glycation, and cellular junk • The real story behind NAD, circadian rhythms, and the tools for better sleep • How to create a personalized health plan that’s sustainable, effective—and fun  Resources:  • Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en• 2025 Biohacking Conference: https://biohackingconference.com/2025 • Kaufmann Protocol Website: https://kaufmannprotocol.com • Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047 • Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com   SPONSORS:  Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Timestamps: • 00:00 Trailer • 00:45 Guest Introduction • 02:30 Longevity Insights • 04:22 Personal Stories • 08:00 Pharmaceuticals • 12:26 Diet and Lifestyle • 18:19 Seven Tenets • 22:04 Sleep and Circadian Rhythms • 26:41 NAD and Supplements • 37:46 Blood Sugar and AGEs • 47:09 Microcirculation • 49:08 NRS and Imports • 49:18 Celebrex Medication • 50:03 Celebrex Benefits • 50:41 Alzheimer’s and Celebrex • 51:28 Antioxidants • 54:26 Stem Cells and Exosomes • 58:03 Laser Skin Treatments • 01:07:34 Hormones and Longevity • 01:20:03 Lithium for Mood • 01:27:45 Gender and Longevity • 01:32:39 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 21 January 2025

Is there actual “magic” on this planet, or is it just in the movies? Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life. From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry reveals the extraordinary power of the “Great 8” — a framework to unlock your potential in relationships, creativity, health, intelligence, and more. This episode is packed with incredible stories, actionable wisdom, and a secret GIFT to help you start your own journey toward unparalleled vitality and longevity! What You’ll Learn:  • The 8 ancient secrets to mastering energy, healing, and peak performance  • How you can harness quantum physics for success  • Why energy techniques can REVERSE aging and boost health naturally  • The science of serendipity and how you can harness it daily  • How to grow stronger, smarter, and healthier every day with simple practices  Resources:   • 2025 Biohacking Conference: https://biohackingconference.com/2025  • Follow Dr. Barry on Instagram: https://www.instagram.com/energyforsuccessofficial/?hl=en  • Explore the Great 8 and Get Your Free Gift: https://energyforsuccess.com/dave/  • Learn More About Energy Practices: https://energyforsuccess.com/  • Danger Coffee: https://dangercoffee.com  • Dave Asprey’s Website: https://daveasprey.com  • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books  • Dave Asprey’s Linktree: https://linktr.ee/daveasprey  • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com  • Own an Upgrade Labs: https://ownanupgradelabs.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com   SPONSORS:  - Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. - Calroy | Head to https://calroy.com/dave for an exclusive discount.  Timestamps:  • 00:00 Trailer  • 01:10 Introduction to Dr. Barry and His Journey  • 06:16 The Turning Point: Mrs. Rodriguez’s Story  • 09:04 Exploring Alternative Medicine Around the World  • 13:02 Discovering Ancient Chinese Healing Techniques  • 16:39 The Power of Quantum Physics and Lao Tzu’s Teachings  • 27:25 Personal Experiences with Energy Healing  • 36:35 The Great Eight: Structuring Your Day for Success  • 36:51 Introduction to Energy for Success  • 37:17 Understanding the Great Eight  • 38:23 The Matrix and Animal Brain  • 44:39 The Importance of Serendipity  • 49:35 Four Categories of People  • 53:02 Personal Experiences and Lessons  • 58:34 The Power of Energy Practices  • 01:07:06 Conclusion and Call to Action See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 16 January 2025

What happens when nearly 60 years of combined biohacking expertise collide in one podcast? Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier.They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical routines you can start today. Peter, the author of The Longevity Guidebook, shares deeply meaningful tools and tips to expand your healthspan for decades to come. What You’ll Learn:  • The top AI tools reshaping health and longevity  • Simple daily habits that improve energy, sleep, and brain performance  • Why mindset is the key to adding years to your life  • The cutting-edge science of age reversal and functional health  • How Peter and Dave biohack their routines for peak performance  Resources:   • 2025 Biohacking Conference: https://biohackingconference.com/2025  • Peter Diamandis’s New Book: https://longevityguidebook.com/home-blk-nav  • Peter Diamandis’s Website: https://www.diamandis.com/  • Peter Diamandis’s Purpose Finder (MTP): https://purposefinder.ai/  • Danger Coffee: https://dangercoffee.com  • Dave Asprey’s Website: https://daveasprey.com  • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books  • Dave Asprey’s Linktree: https://linktr.ee/daveasprey  • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com  • Own an Upgrade Labs: https://ownanupgradelabs.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com  SPONSORS:  -Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to drinklmnt.com/dave.  Timestamps:  • 00:00 Open  • 00:53 Introduction to Peter Diamandis  • 01:54 Peter’s Longevity Journey  • 03:26 Tracking Sleep and Biohacking  • 05:49 The Importance of Deep Sleep  • 07:22 Thinking Big and Longevity  • 10:36 Russian Innovations in Sleep  • 25:29 AI and Longevity  • 29:01 Gene Editing and Epigenetics  • 35:13 Light Therapy and Routines  • 43:07 Gut Health and Endotoxins  • 44:17 Exploring Conscious Pain Practices  • 45:51 Hacking Hot Tubs for Health Benefits  • 46:28 The Science Behind Dopamine Reset  • 46:43 Introduction to Fountain Life  • 48:41 Advanced Diagnostics and AI Integration  • 50:29 Therapeutics and Cutting-Edge Treatments  • 51:41 The Evolution of Longevity Companies  • 55:30 The Future of Longevity and Healthspan  • 01:01:27 The Role of AI in Health and Longevity  • 01:07:31 Personal Longevity Practices and Insights  • 01:16:43 Finding Your Purpose for Longevity  • 01:24:01 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 14 January 2025

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health. Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision training, and how anyone can rewire their brain for sharper sight. If you’re dealing with nearsightedness, eye strain, or just want to keep your eyes sharp as you age, this episode shares simple ways to improve how you see the world—literally! What You’ll Learn: • Why vision training is the next frontier in biohacking • Three free techniques to improve your vision naturally • How your eyesight affects brain performance and energy levels • Why kids and adults need to get outside for better eye health • How to train your eyes to stop relying on glasses Go to www.screenfit.com/enroll and use code DAVE ($200 OFF with the code) Or Visit myvisionfirst.com/dave/ for 5000$ off the premium concierge program!  SponsorsZbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.Resources:  • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Screenfit- Visit https://www.screenfit.com/enroll and use code DAVE ($200 OFF with the code, from $497 to $297) • MyVisionFirst – Visit https://myvisionfirst.com/dave/ and apply now to get $5000 off • Danger Coffee – https://dangercoffee.com • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Timestamps: • 00:00 Intro • 00:29 Dave Asprey’s Vision Journey • 04:33 Understanding Vision Beyond 20/20 • 08:01 Impact of Environment on Vision • 22:47 Exercises to Improve Vision • 27:29 Effective Eye Exercises for Better Vision • 27:46 Daily Routine for Eye Health • 29:12 Peripheral Vision Training • 31:15 Vision and Body Connection • 33:38 Handling Visual Overload • 35:04 Vision Training Benefits • 39:25 Neuroplasticity and Vision • 45:22 Vision Training for All Ages • 46:38 Practical Vision Improvement Tips • 54:24 Final Thoughts on Vision Training See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 9 January 2025

What if the secret to living to 250 was simply sitting in the garden? In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cells and accelerating healing. Christian dives into the fascinating stories behind these plants, their ancient origins, and how modern science is proving their power to extend life. He also shares how anyone—regardless of age—can tap into these natural tools to transform their health and longevity. Imagine harnessing the same methods as a Chinese healer reportedly living to 250 years old. Could these practices be the missing link to longer, healthier lives? What You’ll Learn: • The surprising plants that naturally stimulate stem cells • How stem cells repair and rejuvenate your body from the inside out • Why fasting can reset your cellular health • Practical tips to harness your body’s natural ability to heal • The secrets to improving recovery, energy, and longevity  Resources:  • 2025 Biohacking Conference - STEMREGEN is the Title Sponsor – https://biohackingconference.com/2025 • STEMREGEN Website - Visit stemregen.co/dave and save 20% on STEMREGEN! • Christian Drapeau’s Website - https://christiandrapeau.com  • Danger Coffee – https://dangercoffee.com • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors: Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  Timestamps: • 00:00 Intro • 00:57 Meet Christian Drapeau: Stem Cell Expert • 02:22 Understanding the Innate Repair System • 04:26 Stem Cells and Aging: The Science Explained • 05:27 Fasting and Stem Cell Rejuvenation • 08:34 STEMREGEN: Activating Your Body’s Stem Cells • 12:09 Historical Longevity Practices • 17:59 Enhancing Stem Cell Function: Lifestyle Tips • 22:45 The Role of PEMF in Stem Cell Activation • 26:45 The Importance of Immediate Recovery • 27:22 Stem Cells and Longevity • 28:13 The Bank Account Analogy of Aging • 29:05 Stem Cells and Age-Related Diseases • 30:42 Mind Over Matter: The Brain’s Role in Stem Cell Release • 32:51 The Quantum Mechanics of Stem Cells • 36:22 The Role of Science in Understanding Reality • 42:24 Biological Clocks and Stem Cells • 46:08 Future of Stem Cell Research and Applications • 49:36 Practical Applications and Success Stories • 52:23 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 7 January 2025

Are we protecting our kids—or unknowingly putting their health at risk? Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time. With his integrative and functional approach, Dr. Warsh unpacks the startling rise in chronic illnesses among children and questions if we’re truly asking the hard questions about vaccine safety and efficacy. This isn’t about taking sides—it’s about uncovering the truths every parent needs to know. Dave and Dr. Warsh dive deep into the science, the myths, and the hidden risks Big Pharma doesn’t want you to hear about. Whether you’re a parent, a skeptic, or just someone seeking the truth, this episode will give you the tools and insights to navigate this complex issue with confidence.  What You’ll Learn:  • The alarming rise in chronic illnesses and what might be driving it  • Why vaccine safety studies may not tell the whole story  • The critical questions every parent should ask before vaccinating  • How toxins in our environment are impacting our kids’ health  • Practical steps to protect your children in today’s world   Resources:   • 2025 Biohacking Conference – https://biohackingconference.com/2025  • Dr. Joel “Gator” Warsh’s Book: Parenting at Your Child’s Pace – https://www.amazon.com/Parenting-Your-Childs-Pace-Pediatricians/dp/1454952490  • Dr. Joel “Gator” Warsh’s Website – https://www.integrativepediatrics.com  • Dr. Joel “Gator” Warsh on Instagram – https://www.instagram.com/drjoelgator  • Danger Coffee – https://dangercoffee.com  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors: -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.   Timestamps:  • 00:00 Intro  • 00:40 Personal Health Journey and Pediatric Concerns  • 01:41 Interview with Dr. Joel Gator Warsh  • 02:49 Rising Chronic Diseases in Children  • 04:03 Factors Contributing to Health Issues  • 10:13 Debating Vaccine Safety and Efficacy  • 30:32 Historical Context and Vaccine Research  • 44:18 Introduction to Dr. Joe Dispenza and Meditation  • 45:13 Genetics and Vaccine Controversies  • 46:16 The Importance of Individualized Medicine  • 49:02 Western Medicine’s Flaws and Alternatives  • 50:07 Childhood Health Crisis and Solutions  • 50:52 Pharmaceutical Industry Critique  • 52:09 The Role of Parents and Doctors in Child Health  • 01:04:43 The Influence of Big Pharma on Medicine  • 01:19:56 Balancing Vaccination Decisions  • 01:25:44 Conclusion and Final Thoughts   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 2 January 2025

Your hearing isn’t just about sound—it’s the key to sharper focus, deeper connections, and increased awareness. In this episode, Dave explores the cutting-edge world of hearing technology with Brandon Sawalich, CEO of Starkey, and reveals how you can gain superhuman hearing with almost no effort.“Listening” to this episode is going to be one of the best things for your hearing. But why? Because your hearing isn’t just about detecting sounds—it’s about transforming the way you experience the world. Imagine real-time translation in 75 languages, tuning out noise pollution, and amplifying what truly matters—all while protecting your brain from cognitive decline and boosting your overall performance.Brandon shares the groundbreaking innovations that redefine what hearing devices can do. From biohacking your auditory environment to integrating AI for mood and health tracking, this conversation will change how you think about your ears, your brain, and your future. What You’ll Gain from This Episode: • Discover how superhuman hearing enhances focus and reduces mental fatigue • Learn why better hearing can slow brain aging and improve mental health • Get an inside look at AI-powered hearing technology that’s changing lives • Understand the surprising connection between hearing and peak performance • Find out how upgrading your hearing can unlock new opportunities for success Sponsor: -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  Resources: • Starkey Hearing Technologies – Explore AI-powered hearing aids and innovations: https://www.starkey.com • Starkey Blog – Stay updated on the latest in hearing health: https://www.starkey.com/blog •   Starkey Instagram - https://www.instagram.com/starkeyhearing/ • Danger Coffee – Clean, mold-free coffee for sustained energy: https://dangercoffee.com • Dave Asprey’s Website – Explore biohacking tools, books, and more: https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – Biohacking made simple: https://daveasprey.com/books • Dave Asprey’s Linktree – Access all Dave’s platforms: https://linktr.ee/daveasprey • Upgrade Collective – Join live podcast recordings: https://www.ourupgradecollective.com • Own an Upgrade Labs – Franchise opportunities for cutting-edge health labs: https://ownanupgradelabs.com • Upgrade Labs – The ultimate biohacking experience: https://upgradelabs.com • 40 Years of Zen – Neurofeedback for advanced cognitive enhancement: https://40yearsofzen.com Timestamps: • 00:00 Introduction to Hearing Loss • 01:23 Dave Asprey’s Personal Hearing Journey • 02:47 Guest Introduction: Brandon Sawalich • 03:45 Advancements in Hearing Technology • 06:47 The Importance of Hearing for Brain Health • 17:32 Hearing Aids as Performance Enhancers • 25:32 Future Innovations in Hearing Technology • 27:03 Detecting Lies with Technology • 27:26 The Science of Sleep Enhancement • 29:57 Innovation and Risk-Taking in Business • 32:18 Addressing EMF Concerns with Hearing Aids • 34:26 Ethical Considerations in Technology • 37:06 Empowering Users with AI and Hearing Technology • 43:38 Future of Biohacking and Hearing Superpowers • 44:57 Conclusion and Final ThoughtsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 31 December 2024

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear. Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high. Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live.  Why This Episode Matters:  • You’ll discover how fear sneaks into your decisions—and how to stop it  • Learn why courage is the ultimate skill for success and fulfillment  • Get actionable advice to break through self-imposed limits  • Understand the psychology of fear and how to use it as fuel  • Hear real-life stories of people who overcame fear to achieve greatness  Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Ryan Holiday’s Website – https://ryanholiday.net Daily Stoic Website – https://dailystoic.com/ Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. -Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula.  Timestamps:  • 00:00 – Intro  • 00:44 – Discussing Ryan Holiday’s Work  • 02:37 – The Concept of Courage  • 08:09 – Fear and Courage in History  • 12:41 – Stoic Philosophy and Modern Applications  • 21:50 – The Four Virtues and Their Interrelation  • 28:39 – Challenges in Admitting Mistakes  • 35:21 – Navigating Business Risks During a Pandemic  • 36:44 – The Essence of Courage in Business and Life  • 37:03 – Reed Hastings and the Duality of Courage  • 40:06 – Moral Courage: Lessons from History  • 43:35 – The Debate on Mandates and Personal Freedom  • 45:22 – Balancing Public Health and Individual Rights  • 58:29 – The Role of Responsibility in Society  • 01:09:01 – The Importance of Intellectual Courage  • 01:12:04 – Reaching Audiences in a Noisy World  • 01:13:27 – Final Thoughts and Encouragement See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 26 December 2024

Today we are bringing back one of our all-time favorite episodes with James Altucher. Dave sits down with James, an entrepreneur, bestselling author, and master experimenter, to uncover why the 10,000-hour rule might just be holding you back. Instead of grinding your way to expertise, James reveals his 10,000 Experiment Rule—a game-changing approach to mastering any skill faster than you thought possible. From comedy stages to boardrooms, James has redefined success through relentless experimentation and bold pivots. In this electrifying conversation, he exposes the toxic allure of “failure porn” and why glorifying failure might be sabotaging your growth. You’ll learn why skipping the line isn’t just possible—it’s essential for thriving in a world obsessed with rigid rules. This episode dives deep into the power of curiosity, the art of experimentation, and the strategies James uses to crush the myth of conventional wisdom. Whether you’re stuck in a career rut, looking to start something new, or just want to optimize your life, James delivers unfiltered insights to help you rewrite the rules.  What You’ll Learn: • Why the 10,000-hour rule is outdated—and what actually works • How “failure porn” is dragging you down (and how to escape it) • The 10,000 Experiment Rule that accelerates skill mastery • Bold strategies to break through limits and skip the line in any industry • Why curiosity is the ultimate superpower for growth and success • Practical steps to monetize your passion and build a life you love  Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 James Altucher’s Website – https://www.jamesaltucher.com The James Altucher Show Podcast – https://podcasts.apple.com/us/podcast/the-james-altucher-show/id794030859 Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors -Calroy | Head to https://calroy.com/dave for an exclusive discount. -Viome | Go to https://viome.com/dave to save $110 on the Full Body Intelligence Test.  Timestamps: 00:00 Introduction to The Human Upgrade Podcast 00:38 Meet James Altucher: Entrepreneur and Author 01:02 The Comedy Journey: From Advice to Stage 02:06 The Controversial New York Article 03:42 Facing Backlash and Public Reaction 10:46 The 10,000 Experiment Rule 15:44 Skipping the Line: Challenging Conventional Wisdom 23:35 The Importance of Loving What You Do 31:30 A Chance Encounter with Howard Schultz 32:11 The Plus Minus Equals Technique 33:26 Applying Techniques to Chess Mastery 34:43 The Importance of Curiosity 36:30 Experimenting with Comedy 38:44 The Concept of Failure Porn 40:39 The Hero’s Journey in Business 44:42 Living an Experimental Life 47:10 Frame Control in High-Stakes Situations 53:43 Advice for Parents and Kids 55:29 Conclusion and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 24 December 2024

Can you use hate to make the world a better place?  Daryl Davis, a world-class jazz musician, didn’t just confront hate—he dismantled it. By sitting down with over 200 Ku Klux Klan members, he inspired them to leave their robes behind. But this isn’t just a story about racism or redemption; it’s a story about the incredible power of human connection and the lessons it holds for all of us. In this special episode, Dave explores how Daryl turned impossible conversations into transformative breakthroughs. Together, they unpack the mindset shifts, emotional intelligence, and fearless curiosity that can break down barriers of all kinds—whether they’re rooted in bias, fear, or misunderstanding. Daryl’s approach to erasing hate is so unique, so impactful, that it may just change how you view conflict, compassion, and even your own health.  What You’ll Learn:  • How Daryl’s global upbringing shaped his fearless approach to conflict  • Why eliminating hate starts with understanding, not opposition  • The neuroscience of compassion and how it rewires your brain  • How forgiveness can transform your health and happiness  • A step-by-step framework for tackling impossible conversations  Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Daryl Davis's Book: Klan-destine Relationships (Go read it for free at your local library instead of buying on Amazon :)) Daryl Davis's Website – https://www.daryldavis.com Daryl Davis on Instagram – https://www.instagram.com/realdaryldavis/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors: -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  Timestamps:  • 00:00 A Shocking Parade Experience  • 00:38 Meeting the KKK: First Impressions  • 01:06 Introducing Daryl Davis  • 03:46 Daryl’s Unique Upbringing  • 09:52 Confronting Racism: A Lifelong Quest  • 14:16 The Power of Travel and Perspective  • 18:25 A High School Encounter with Nazis  • 21:12 Confronting the Klan Leader  • 30:57 Changing Minds: A Personal Approach  • 36:30 The Illusion of Latent Genes  • 42:08 Collecting Klan Robes: A Symbolic Victory  • 46:17 Facing the Klan: Staying Grounded  • 48:27 Challenging Beliefs: Confronting Hate  • 49:15 The Journey to Writing ‘Clandestine’  • 50:26 Introducing ‘The Klan Whisperer’  • 51:35 Reflections on Racism and History  • 57:29 The Power of Forgiveness  • 59:28 Freedom of Speech and Its Limits  • 01:02:21 Personal Stories of Racism  • 01:13:16 Cultural Understanding and Misunderstandings  • 01:25:16 The Impact of Music on Memory  • 01:29:02 Final Thoughts and Upcoming Events See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 19 December 2024

Is AI About to Replace Your Doctor? Or Save Your Life? The tools that are reshaping healthcare will redefine medicine—and your life—in ways you’ve never imagined. Will artificial intelligence and regenerative therapies like stem cells and exosomes make doctors obsolete? Or will they finally unlock the secrets to living to 180? In this episode, Dave sits down with Dr. Pradeep Albert, a leader in regenerative medicine and AI-driven imaging, to explore the intersection of technology, longevity, and healing.  Dr. Albert shares groundbreaking insights on how AI is revolutionizing medical diagnostics, replacing outdated systems, and empowering patients to take control of THEIR OWN health. He also dives deep into regenerative therapies—how PRP, exosomes, and stem cells are changing the game for injuries, inflammation, and aging.  Can AI improve patient-doctor relationships? Are doctors becoming coaches instead of gatekeepers? And most importantly, how can you leverage these tools to outlive your peers and enhance every aspect of your health?  What You’ll Learn:  • Why 50% of people won’t make it past 76—and how to beat the odds  • How AI is already better than doctors at diagnosing certain conditions  • The truth about PRP, exosomes, and stem cells—and when to use each  • The three rules of longevity every person needs to know  • How your mindset and epigenetics can help you live longer and healthier  Resources:   2025 Biohacking Conference – https://biohackingconference.com/2025 Dr. Pradeep Albert’s Book: Exosomes, PRP, and Stem Cells…Medicine – https://www.amazon.com/Exosomes-Stem-Cells-Musculoskeletal-Medicine/dp/B0C2S59S8K Dr. Pradeep Albert’s Book: Lifespan Decoded –https://lifespandecoded.com/ Dr Pradeep Albert’s Website – https://drpradeepalbert.com/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com   Sponsors:  ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  OneSkin | Go to https://oneskin.co/ and use code ASPREY15 for 15% off your purchase.  Timestamps:  • 00:00 – Introduction to AI in Medicine  • 00:36 – The Role of AI in Longevity  • 00:51 – Meet Dr. Pradeep Alpert  • 01:11 – AI’s Impact on Healthcare  • 02:07 – Changing Role of Doctors  • 05:01 – AI in Medical Imaging  • 06:37 – Orthopedics and AI  • 09:19 – Longevity and Epigenetics  • 14:16 – The Importance of Mindset  • 29:08 – Trust in the Medical System  • 43:18 – DIY Health and Longevity  • 44:21 – The Future of Insurance and Medical Costs  • 45:45 – Advancements in Imaging Technology  • 47:26 – The Art of Physical Examination  • 50:21 – Regenerative Medicine: PRP, Exosomes, and Stem Cells  • 01:00:23 – Challenges in the US Medical System  • 01:07:54 – The Role of AI in Medicine  • 01:18:14 – Final Thoughts and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 17 December 2024

Most people don’t think about their liver until it’s too late. In this episode, Dave sits down with Siggi Clavien, founder of de-liver-ance® & The Liver Clinic, to uncover the hidden superpowers of the body’s most underrated organ: the liver. This is a deep dive into why your liver is the ultimate game-changer for your energy, brain power, and longevity. Siggi reveals groundbreaking insights on reversing fatty liver disease, boosting detoxification, and harnessing the liver’s regenerative capabilities. From fighting brain fog to protecting against toxins, this episode will have you rethinking everything about how you treat your body. And yes, your liver could be the key to living a healthier, happier life. Siggi also shares the science and innovation behind de-liver-ance®, his groundbreaking herbal product designed to deliver the most powerful results in a safe, natural way. Backed by millions of dollars and years of research, de-liver-ance® is setting a new standard in liver health. Use code: DAVE at https://us.loveyourliver.com/discount/DAVE to get a discount! Dave and Siggi also explore cutting-edge strategies to supercharge your liver health using natural herbs, breakthrough science, and biohacking tools. What You’ll Learn: • Why your liver holds the key to longevity, energy, and mental clarity • How to reverse fatty liver disease—even if you’ve been told it’s irreversible • The truth about common liver-destroying habits you need to ditch now • Groundbreaking ways to protect and regenerate your liver for optimal health • The science behind de-liver-ance® and how it’s changing liver health forever • Simple, actionable strategies to boost detoxification and supercharge your body  Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 de-liver-ance® – https://us.loveyourliver.com/discount/DAVE (Use code DAVE at checkout for a discount!) The Liver Clinic – https://theliverclinic.com Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Timestamps: • 00:00 Intro • 00:00 Introduction and Liver Basics • 01:46 Guest Introduction and Liver Health Insights • 02:16 Understanding Liver Scans and Lab Panels • 05:13 Fatty Liver Disease: Causes and Consequences • 07:07 Diet and Liver Health • 09:47 Supplements and Liver Function • 11:53 Advanced Liver Health Strategies • 14:05 Biohacking and Liver Health • 17:41 Deliverance Supplement and Its Benefits • 23:12 Liver Health and Longevity • 31:12 Biohacking: The Path to Consciousness and Longevity • 32:29 The Liver: The Body’s Regenerative Powerhouse • 34:48 Gut Microbiome and Liver Health Connection • 35:59 Lipopolysaccharides: The Hidden Toxins • 40:44 Coffee: A Surprising Ally for Liver Health • 43:16 Mold Toxins: The Silent Liver Destroyers • 48:43 Hormone Health and the Liver • 52:19 Type 2 Diabetes, Menopause, and Liver Health • 52:43 The Impact of Lifestyle on Liver Health • 54:57 The Importance of Bile and Gallbladder Health • 58:06 Genetics, Toxins, and Liver Resilience • 01:06:25 Conclusion: Investing in Liver Health for a Better Life See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 13 December 2024

Most people don’t think about their liver until it’s too late. In this episode, Dave sits down with Siggi Clavien, founder of The Liver Clinic, to uncover the hidden superpowers of the body’s most underrated organ: the liver. This is a deep dive into why your liver is the ultimate game-changer for your energy, brain power, and longevity. Siggi reveals groundbreaking insights on reversing fatty liver disease, boosting detoxification, and harnessing the liver’s regenerative capabilities. From fighting brain fog to protecting against toxins, this episode will have you rethinking everything about how you treat your body. And yes, your liver could be the key to living a healthier, happier life. Siggi also shares the science and innovation behind De-liver-ance, his groundbreaking herbal product designed to deliver the most powerful results in a safe, natural way. Backed by millions of dollars and years of research, De-liver-ance is setting a new standard in liver health.  Use code: DAVE at https://us.loveyourliver.com/discount/DAVE to get a discount! Dave and Siggi also explore cutting-edge strategies to supercharge your liver health using natural herbs, breakthrough science, and biohacking tools.  What You’ll Learn:  • Why your liver holds the key to longevity, energy, and mental clarity  • How to reverse fatty liver disease—even if you’ve been told it’s irreversible  • The truth about common liver-destroying habits you need to ditch now  • Groundbreaking ways to protect and regenerate your liver for optimal health  • The science behind De-liver-ance and how it’s changing liver health forever  • Simple, actionable strategies to boost detoxification and supercharge your body  Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 De-liver-ance – https://us.loveyourliver.com/discount/DAVE (Use code DAVE at checkout for a discount!) The Liver Clinic – https://theliverclinic.com Equilibrium Labs – https://equilibriumlabs.com Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Timestamps:  • 00:00 Intro  • 00:00 Introduction and Liver Basics  • 01:46 Guest Introduction and Liver Health Insights  • 02:16 Understanding Liver Scans and Lab Panels  • 05:13 Fatty Liver Disease: Causes and Consequences  • 07:07 Diet and Liver Health  • 09:47 Supplements and Liver Function  • 11:53 Advanced Liver Health Strategies  • 14:05 Biohacking and Liver Health  • 17:41 Deliverance Supplement and Its Benefits  • 23:12 Liver Health and Longevity  • 31:12 Biohacking: The Path to Consciousness and Longevity  • 32:29 The Liver: The Body’s Regenerative Powerhouse  • 34:48 Gut Microbiome and Liver Health Connection  • 35:59 Lipopolysaccharides: The Hidden Toxins  • 40:44 Coffee: A Surprising Ally for Liver Health  • 43:16 Mold Toxins: The Silent Liver Destroyers  • 48:43 Hormone Health and the Liver  • 52:19 Type 2 Diabetes, Menopause, and Liver Health  • 52:43 The Impact of Lifestyle on Liver Health  • 54:57 The Importance of Bile and Gallbladder Health  • 58:06 Genetics, Toxins, and Liver Resilience  • 01:06:25 Conclusion: Investing in Liver Health for a Better Life See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcribed - Published: 13 December 2024