The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel : 1292
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 17 June 2025
⏱️ 72 minutes
🧾️ Download transcript
Summary
Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin’s mitochondria, accelerate senescence, and trigger systemic inflammation. You’ll learn how to reverse this damage, support cellular repair, and choose smarter formulations that work with your biology for long-term skin and brain health.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Amitay Eshel, a pioneer in biohacking skincare and founder of Young Goose. With expertise in regenerative aesthetics and advanced bioactive formulations, Amitay is leading the charge in applying longevity science, epigenetics, and senolytics to skincare. His work helps high performers integrate topical nootropics, mitochondrial support, and neurohacking principles directly into their daily routine through the skin.
You’ll explore how skin aging connects to brain inflammation, how leaky skin barriers affect immune health, and why most anti-aging trends are outdated or biologically disruptive.
The Human Upgrade unpacks how red-light therapy, ketosis, cold therapy, fasting, and self-quantification tools can be leveraged to enhance skin function from the inside out. This is a masterclass in smarter not harder skincare, rooted in cellular optimization and performance longevity.
This episode is essential listening for anyone serious about biohacking, human performance, skincare longevity, mitochondria, Upgrade Labs-style recovery, and science-backed beauty routines.
You’ll learn:
• Which anti-aging skincare trends actually age you faster
• How mitochondria and senescent cells influence visible aging and inflammation
• What role neurohacking and the skin-brain connection play in longevity
• How to repair the skin barrier and reduce oxidative stress naturally
• The best red light, cold therapy, and fasting tools to reverse skin aging
• How to use skin as a self-quantification tool for overall health
• Why smarter skincare equals better cognitive and biological performance
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
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Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Young Goose Website – https://www.younggoose.com/ and use code “Dave10” at checkout to get a discount!
• Young Goose Instagram: https://www.instagram.com/young_goose_skincare/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 00:52 – Intro
• 01:27 – Anti-Aging Mistakes
• 05:20 – Skin Recovery Science
• 07:44 – NAD & Mitochondria
• 08:52 – Autophagy Compounds
• 12:06 – Sleep & Topicals
• 18:36 – Overtraining Effects
• 21:07 – Vitamin C & Antioxidants
• 28:48 – Breakthrough Formulations
• 35:50 – Tallow vs. MCT
• 36:11 – Sun & Longevity
• 37:28 – Red Light Therapy
• 40:12 – UV Light Benefits
• 42:18 – Advanced Skincare Tech
• 48:48 – NAD Topicals
• 01:00:05 – Building Your Routine
• 01:07:39 – Final Takeaways
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | If you minimize oxidative stress in your skin, you're going to get better responses as far as like UV radiation. |
| 0:05.9 | Old skin equals old brain. |
| 0:07.3 | Old skin equals a brain that is being inflamed, not only an older brain, but a brain that actually ages the body. |
| 0:14.0 | I have artificial light on me. |
| 0:16.3 | These lights actually lower the energy production of my skin cells. So they lower ATP. You see like a lot of |
| 0:23.9 | people now saying, oh, the sun is like 80% of why your skin is aging. That is not only not true. If you look |
| 0:30.9 | at correctly correlated studies as far as like how we live our life, 60% of why you age is because of environmental factors that are non-UV. |
| 0:40.8 | A lot of our allergic triggers are from leaky skin barrier. |
| 0:44.3 | And using a good quality skin care seals the barrier. |
| 0:47.4 | What are the things that I should be looking for in the topicals that I use? |
| 0:53.6 | You're listening to The Human Upgrade with Dave Asprey. |
| 0:59.8 | I'm going to say it's so fun to talk with you because you're also a biohacker and you have this, |
| 1:06.7 | well, you know, I'm technical and then I started working with lasers and light and radio |
| 1:12.0 | frequency stuff, and then you started working with longevity compounds on the skin. |
| 1:16.3 | And most of the biohacking world, they kind of missed how important the skin is as an organ |
| 1:23.6 | and as a way to get substances into the body. |
| 1:27.2 | And the stuff you're doing at Young Goose is really |
| 1:29.0 | interesting because you have a different frame on beauty as we have your biohacking beauty show. |
| 1:35.2 | I've heard you say that a lot of anti-aging treatments actually age your skin. Why? First of all, |
| 1:41.0 | it really depends on who you are and how you, you know, how you show up to that treatment. |
| 1:47.2 | So if you are the Tom Brady or the Dave Asprey of youthful function, you can get away with a lot of things. |
| 1:55.6 | But 99.9% of people aren't. |
... |
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