Top 5 Dopamine Boosting Biohacks for Superhuman Energy : 1310

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 5 August 2025

⏱️ 69 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance.

Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition.

They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery.

Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism.

You’ll Learn:

• The #1 Russian compound for explosive dopamine and drive

• Why most “calming” supplements destroy your ambition

• How dopamine and DHT shape masculinity and performance

• Advanced biohacks for sleep, motivation, libido, and mood

• The truth about serotonin dominance and how to escape it

• Which functional medicine tools enhance brain energy and metabolism

• How to build your own dopamine protocol using proven nootropics

• Why mitochondrial health is the hidden key to motivation and mood

This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Thank you to our sponsors!

OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.

Resources:

• Lucas’s Website: https://www.boostyourbiology.com/

• Lucas’s YouTube: https://www.youtube.com/c/boostyourbiology

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Tags:

dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols

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Transcript

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0:00.0	Have you ever looked at some kind of skincare product and that I wonder if this is going to work?
0:04.7	With OneSkin, you don't have to wonder because they have proof and a lot of it.
0:09.7	That's because OneSkin is founded by scientists who specialize in tissue engineering and stem cell biology and skin regeneration.
0:16.9	And they've got rigorous lab studies and clinical studies showing that one skin products work.
0:21.7	Their entire product line is incredible and I do use it. At the heart of all of their topical
0:26.3	supplements is their proprietary OS1 peptide. It's the first ingredient that reverses your
0:32.4	skin's biological age by targeting cellular senescence. These are the zombie cells that make
0:37.0	your skin and your body
0:38.0	age faster, and you read about them in my longevity book. You can find research on OS1 published in the
0:43.3	peer-reviewed journal, NPJ aging, and they list all of the data for OS1 and their products on their
0:49.2	website. And check this out. In lab studies, their OS1 eye cream increased collagen production by 130%.
0:56.1	Another study showed that their sunscreen neutralizes free radicals four times better than other anti-aging sunscreens.
1:03.5	The proof is in the data.
1:04.8	Try OneSkin, and you'll see the benefits for yourself.
1:07.2	To get 15% off your first purchase, go to Oneskin.co slash Asprey and use code
1:12.3	Asprey. If I want to be good at public speaking and I want more confidence, it's very important
1:20.8	to have high levels of dopamine because that's the confidence. Lucas Aoun is Australia's best
1:26.1	known biohacker and men's health expert,
1:28.3	breaking down cutting-edge science into real-world tools for energy, focus, and hormonal dominance.
1:34.0	He's not just leading the game.
1:35.9	He's changing it.
1:36.8	What is the single most powerful non-psychedelic compound that you've used to hack your dopamine system.
	...

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