Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 7 August 2025
⏱️ 104 minutes
🧾️ Download transcript
Summary
What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation.
In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health.
You’ll Learn:
• Who should use estradiol—and how it can protect brain performance in men
• The real role of testosterone and estradiol synergy in male health and longevity
• How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health
• Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care
• The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15
• What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks
• Why libido and metabolic health are deeply connected
• The dangers of unvetted peptide sources—and what to look for in quality and bioavailability
This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living.
Keyword Index:
estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Thank you to our sponsors!
- Puori | Head to http://puori.com/dave for 20% off, including subscriptions.
- Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.
- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.
Resources:
• BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE#
• Dave Asprey’s Website: https://daveasprey.com
• Danger Coffee: https://dangercoffee.com/DAVE15
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
00:00 – Trailer
01:00 – Introduction & Early Days of Biohacking
02:03 – Peptides 101: Foundations and Frameworks
03:06 – Peptides for Healing, Cognition, and Longevity
07:56 – Bioregulators and Russian Innovations
11:07 – Side Effects and Safety of Peptides
22:27 – Oral Peptides and Product Innovations
27:41 – Body Composition, Hormones, and Fat Loss
32:02 – Testosterone, Estrogen, and Male Health Protocols
45:03 – Peptides for Performance, Fat Loss, and Longevity
1:26:32 – Loose Skin, Surgery, and Body Transformation
1:38:00 – Closing Thoughts & Product Recommendations
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | If you've already dialed in your diet and your training, but you're still hitting a wall, it's probably not just aging. |
| 0:06.5 | There's a powerful compound that your body used to make, but it doesn't make it anymore. |
| 0:11.0 | It's called creatine, and it might be the missing link for your performance and your longevity. |
| 0:16.6 | Puri has a solution for you. |
| 0:18.5 | It's called creatine plus, because creatine isn't just for your muscles, |
| 0:22.2 | it's for your brain and for your mitochondria. Creatine supports mitochondrial function, which supports |
| 0:27.5 | cognitive clarity. And it's one of the most underrated tools for having more brain energy, |
| 0:32.7 | more recovery, and even for longevity, especially as your age or just because you pulled another all-nighter. |
| 0:39.3 | Puri's creatine plus is next level clean and effective. |
| 0:42.8 | Each serving has a clinically backed 5 grams of creatine plus 400 milligrams of taurine. |
| 0:48.7 | This is a powerful amino acid that can support your brain, your muscles, and your bones |
| 0:52.6 | without any kind of jittery or stimulant side effects. Puree tests every single batch for over 200 contaminants, and they have |
| 0:59.5 | the certified clean label from the Clean Label project. You can even scan the QR code right on the |
| 1:04.6 | bottle to see your batch's results. It's unflavored, it's easy to mix. Just toss it in water or |
| 1:10.0 | your morning shake, or even your danger coffee. No extra steps, no strange taste, just results. Add it to your routine and give your body and your brain what it's missing. Go to puri.com slash Dave. That's p-u-o-r-I-com slash Dave to get 20% off, including subscriptions. |
| 1:32.1 | Every guy in my family has man boobs i don't have man boobs anymore because i control my estrogen levels most people think estrogen is the devil but for man |
| 1:38.2 | it actually drives a lot of our sex drive and a lot of our cognition most people when they get |
| 1:42.0 | super super lean they're going to aromatize less of their testosterone |
| 1:45.0 | into estrogen, which leads to lower libido. |
| 1:47.0 | It leads to kind of this brain fog. |
| 1:49.0 | Jay Campbell and Hunter Williams have spent years at the edges of health science, using tools |
| 1:53.0 | most people never hear about outside the dark corners of the gym. |
... |
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