The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 19 June 2025
⏱️ 71 minutes
🧾️ Download transcript
Summary
Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, investigated the most overlooked environmental toxins, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance.
Together, they break down:
• How rare plant compounds like osmotin support adiponectin and mitochondrial repair
• Why PFAS, synthetic fragrances, and EMFs are sabotaging your biology
• How environmental toxins contribute to hormone disruption and infertility
• What makes tap water so dangerous and how to fix it with simple filtration
• Why microplastics and heavy metals are harder to avoid than ever
• The role of habit design, detox protocols, and indoor air quality in biohacking longevity
• Why removing toxins first leads to better results in fasting, ketosis, nootropics, and cold therapy
This episode delivers practical tools for building resilience, improving detox capacity, and navigating the modern world with awareness. You’ll also get insights into the systems that have failed to protect public health and how personal action can create collective change.
If you’re interested in senolytics, sleep optimization, neurohacking, and smarter ways to upgrade your environment, you’ll find those topics explored in depth throughout this channel.
Whether you’re detoxing from hidden toxins or optimizing with Danger Coffee, this conversation aligns with the core principles of Smarter Not Harder and the mission of Upgrade Labs.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
-Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Darin’s Website – https://superlife.com/
• Darin’s Instagram: https://www.instagram.com/darinolien/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Intro
• 02:14 Meet Darin Olien
• 04:26 Wildfires and Pollution
• 07:13 PFAS and Everyday Toxins
• 12:37 Corporate and Regulatory Failure
• 26:36 Synthetic Fragrances
• 36:12 Water and Air Filtration
• 36:53 Indoor Air Quality
• 38:33 Building Healthy Habits
• 40:05 Essential Oils and Hormones
• 41:54 Tofu, Tempeh, and Estrogen
• 46:34 Adiponectin and Biohacking
• 47:04 Osmotin for Longevity
• 49:48 Stem Cells and Repair
• 53:57 Communicating Science
• 01:04:12 Nutrition and the Microbiome
• 01:06:14 Final Thoughts
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Transcript
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| 0:00.0 | Have you ever looked at some kind of skincare product and that I wonder if this is going to work? |
| 0:04.7 | With OneSkin, you don't have to wonder because they have proof and a lot of it. |
| 0:09.7 | That's because OneSkin is founded by scientists who specialize in tissue engineering and stem cell biology and skin regeneration. |
| 0:16.9 | And they've got rigorous lab studies and clinical studies showing that one skin products work. |
| 0:21.7 | Their entire product line is incredible and I do use it. At the heart of all of their topical |
| 0:26.3 | supplements is their proprietary OS1 peptide. It's the first ingredient that reverses your |
| 0:32.4 | skin's biological age by targeting cellular senescence. These are the zombie cells that make |
| 0:37.0 | your skin and your body |
| 0:38.0 | age faster, and you read about them in my longevity book. You can find research on OS1 published in the |
| 0:43.3 | peer-reviewed journal, NPJ aging, and they list all of the data for OS1 and their products on their |
| 0:49.2 | website. And check this out. In lab studies, their OS1 eye cream increased collagen production by 130%. |
| 0:56.1 | Another study showed that their sunscreen neutralizes free radicals four times better than other |
| 1:01.9 | anti-aging sunscreens. The proof is in the data. Try OneSkin, and you'll see the benefits for yourself. |
| 1:07.2 | To get 15% off your first purchase, go to OneSkin.co slash Asprey and use code |
| 1:12.3 | Asprey. The reason we cook plants is to reduce toxins. We ferment and we process the hell out of |
| 1:18.7 | them. We have compounds and plants that we ingest and they actually support us in our health |
| 1:24.1 | and improves virtually all longevity markers in the body. |
| 1:28.4 | So there are studies today that are reversing Parkinson's, Alzheimer's, dementia. |
| 1:35.5 | We induce this high active compound naturally implants, and it binds to pathways in our |
| 1:43.1 | body and our body start freaking healing. |
| 1:46.3 | Known as the Superfood Hunter, Darren O'Lean is the author of the New York Times bestseller |
| 1:51.3 | Super Life and the host of the number one health and wellness podcast around the Darren |
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