Easy Oxygen Hacking for Mitochondria (The 15-Minute Upgrade) : 1301
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 15 July 2025
⏱️ 55 minutes
🧾️ Download transcript
Summary
Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, an affordable and science-backed way to do Exercise With Oxygen Therapy (EWOT) at home. After nearly dying from autoimmune illness and failed functional medicine treatments, Brad used this oxygen-based biohacking tool to fully reboot his health. His story and system offer breakthrough potential for anyone facing fatigue, inflammation, or looking to upgrade energy, resilience, and longevity.
You’ll learn:
• How EWOT works differently from hyperbaric oxygen and why it’s faster
• Why brain fog, poor sleep, and chronic inflammation all trace back to oxygen supply
• How oxygen hacking activates neuroplasticity, detox pathways, and energy production
• When to stack with ketosis, red light, nootropics, and mitochondrial supplements
• How elite athletes and chronically ill patients both use this protocol
• Why “Smarter Not Harder” starts with oxygen-fueled mitochondrial upgrades
This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, metabolism, fasting, supplements, and longevity.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Get a free Ebook on EWOT to learn more today:
SPONSORS:
- Puori | Head to http://puori.com/dave for 20% off, including subscriptions.
- BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.
- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• One Thousand Roads Website: https://www.onethousandroads.com/
• One Thousand Roads YouTube (more info on EWOT) : https://www.youtube.com/@OneThousandRoadsHQ
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Labs: https://upgradelabs.com
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Introduction
• 02:38 Discovering EWOT
• 03:55 Autoimmune Breakdown
• 06:54 Building One Thousand Roads
• 15:00 EWOT Science & Benefits
• 20:54 Protocols & Use Cases
• 29:03 Real-World Results
• 30:11 Brain Fog & Oxygen
• 30:58 Athletic Performance
• 31:41 Therapy Stacking
• 34:44 Mitochondria & Aging
• 37:08 Research & Studies
• 40:00 Future of Oxygen Therapy
• 43:02 Practical Tips & Access
• 51:09 Final Takeaways
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | If you've already dialed in your diet and your training, but you're still hitting a wall, it's probably not just aging. |
| 0:06.5 | There's a powerful compound that your body used to make, but it doesn't make it anymore. |
| 0:11.0 | It's called creatine, and it might be the missing link for your performance and your longevity. |
| 0:16.6 | Puri has a solution for you. |
| 0:18.5 | It's called creatine plus, because creatine isn't just for your muscles, |
| 0:22.2 | it's for your brain and for your mitochondria. Creatine supports mitochondrial function, which supports |
| 0:27.5 | cognitive clarity. And it's one of the most underrated tools for having more brain energy, |
| 0:32.7 | more recovery, and even for longevity, especially as your age or just because you pulled another all-nighter. |
| 0:39.3 | Puri's creatine plus is next level clean and effective. |
| 0:42.8 | Each serving has a clinically backed 5 grams of creatine plus 400 milligrams of taurine. |
| 0:48.7 | This is a powerful amino acid that can support your brain, your muscles, and your bones |
| 0:52.6 | without any kind of jittery or stimulant side effects. Puree tests every single batch for over 200 contaminants, and they have |
| 0:59.5 | the certified clean label from the Clean Label project. You can even scan the QR code right on the |
| 1:04.6 | bottle to see your batch's results. It's unflavored, it's easy to mix. Just toss it in water or |
| 1:10.0 | your morning shake, or even your danger coffee. No extra steps, no strange taste, just results. Add it to your routine and give your body and your brain what it's missing. Go to puri.com slash Dave. That's p-u-o-r-I-com slash Dave to get 20% off, including subscriptions. |
| 1:28.3 | Increasing metabolic demand in a very high oxygen environment has unique metabolic benefits |
| 1:33.9 | that turn off in some cases tons of autoimmune inflammation. |
| 1:37.7 | Every year past the age of 25, you lose 1% of your ability to utilize oxygen. |
| 1:44.7 | One of the major reasons for this is inflammation within the capillaries. |
| 1:49.0 | Inflammation is at the root of basically every chronic health condition we have out there. |
| 1:53.2 | Brad Pittsley, founder of 1,000 Rhodes. |
| 1:56.0 | After being diagnosed with metastatic melanoma and multiple autoimmune conditions, Brad discovered exercise |
... |
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