The Anti-Aging Chamber That Rewinds Your Biological Clock|Dr. Jason Sonners : 1281
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 15 May 2025
⏱️ 53 minutes
🧾️ Download transcript
Summary
Your cells are starving. Not for food—but for oxygen.
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science.
You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed.
This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level.
You’ll Learn:
• How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair
• Why mild-pressure chambers may be more powerful than you think
• What HBOT does to inflammation, brain fog, and biological aging markers
• How to stack HBOT with fasting, red light, and methylene blue for amplified results
• What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression
• The truth about oxygen toxicity—and how to avoid the common mistakes
• How elite performers use HBOT for brain optimization, recovery, and resilience
** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ **
Thank you to our sponsors!
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Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Jason's Website – www.hbotusa.com
• OxyHealth Website: https://www.oxyhealth.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:59 Intro
• 03:14 New research on aging and oxygen
• 05:39 Mild vs. hard-shell chambers
• 13:05 HBOT for longevity and stem cells
• 16:43 How to optimize your sessions
• 22:35 Best therapies to stack with HBOT
• 25:40 Oxygen delivery and safety
• 26:43 Altitude and chamber effects
• 30:01 Key benefits of hyperbaric therapy
• 34:22 Supplement synergy and timing
• 37:25 Pressure and oxygenation findings
• 39:27 Medical vs. welding oxygen
• 44:57 Safety myths and toxicity risks
• 47:39 Future of biohacking with oxygen
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Transcript
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| 0:00.0 | There's short-term and long-term effects of hyperbaric, and one of the most significant short-term effects is as you drive more oxygen into a cell, you start making more energy almost immediately. |
| 0:10.6 | You wake up breathing. You think you're alive. You think it's enough. But your cells are gasping. Your energy is flickering. You feel too much pressure, but there's one pressure that could save you. For decades, hyperbaric |
| 0:22.2 | therapy was misunderstood, a safety net for scuba divers, a last resort for burn victims, a tool |
| 0:28.4 | for survival, not performance. Today, the science is undeniable. Oxygen under pressure isn't |
| 0:34.3 | just a rescue protocol. It's a trigger for regeneration, a weapon for resilience, |
| 0:39.6 | and a gateway to living younger, longer, and stronger. |
| 0:43.4 | It triggers your stem cells. |
| 0:44.8 | It rewrites your epigenome. |
| 0:46.5 | It rebuild your mitochondria and slows your biological aging |
| 0:50.2 | at the source, but only if you use it right. |
| 0:52.6 | It's a systemic therapy. |
| 0:54.1 | It's not a targeted therapy. |
| 0:55.6 | And when you deal with systemic therapies, |
| 0:57.6 | there's so many different avenues to go down, |
| 1:00.6 | to understand the pathways that people see change and improvement. |
| 1:05.1 | Dr. Jason Sauners is leading the charge, |
| 1:07.7 | a pioneer in regenerative medicine, |
| 1:09.8 | a world authority in hyperbaric therapy, |
| 1:12.2 | and one of the few pushing hyperbaric from recovery to an engineering tool for performance and longevity. |
| 1:18.6 | Because hyperbaric isn't a backup plan, it's a first move. Not after you break, before you do. |
| 1:24.3 | If you're already doing some fasting, which is going to maximize your autophagy, and you're |
| 1:28.3 | doing hyperbaric, which is going to magnify that effect, and the hyperbaric is now stimulating |
... |
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