Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 11 April 2025
⏱️ 61 minutes
🧾️ Download transcript
Summary
If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?
For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that?
In this episode, Dave Asprey uncovers the cellular biology of hair thinning with longevity researcher Carolina Reis Oliveira. You’ll learn how senescent cells (aka zombie cells) hijack your scalp, disrupt follicle function, and silently accelerate hair loss—and how a breakthrough peptide might stop it cold.
Carolina reveals brand-new clinical research on OS-01, a molecule shown to increase hair density by 40% in just 6 months. But this isn’t a product pitch—it’s a paradigm shift. Together, they explore the hidden drivers of hair aging, from hormone shifts and stress cascades to microbiome imbalances and inflammation, plus the real science behind what can actually regrow hair.
What You’ll Learn in This Episode:
• How “zombie cells” (senescent cells) sabotage your hair from the inside out
• The science behind the OS-01 peptide and how it reverses visible hair thinning
• Why thinning hair isn’t just genetic—and what else is driving it
• How stress, hormones, and aging collide to trigger follicle dysfunction
• What your scalp microbiome has to do with regrowth and hair density
• How to stack red light, peptides, and topicals for real, measurable results
***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.***
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• OneSkin Instagram – https://www.instagram.com/oneskin.co/
• OneSkin Website: https://www.oneskin.co/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 — Trailer
• 01:52 — Intro
• 02:59 — Is Aging Optional for Your Scalp?
• 04:03 — Understanding Scalp and Hair Aging
• 05:06 — The Role of Senescent Cells in Hair Loss
• 07:25 — Hormonal Influences on Hair Health
• 16:10 — Peptide Solutions for Hair Thinning
• 18:05 — Clinical Studies and Results
• 20:29 — Future of Hair Loss Treatments
• 30:16 — Nutritional and Lifestyle Factors
• 36:40 — Addressing Senescent Cells and Hair Growth
• 37:29 — Minoxidil: Oral vs. Topical Use
• 39:32 — Personal Experience with Hair Products
• 40:25 — Combining Therapies for Hair Growth
• 46:06 — Nutritional Factors in Hair Health
• 52:20 — Sun Exposure and Hair Health
• 56:40 — Coffee and Hair Growth
• 01:00:01 — Launching the New Hair Product
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Transcript
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| 0:00.0 | The scalp of the skin basically has a similar structure of the skin in your face. |
| 0:05.1 | So your hair follicles are basically embedded in the epidermal layer. |
| 0:09.9 | And so a lot of the things that we see happening in the skin of our face also happens in our scalp. |
| 0:16.3 | You don't notice it at first. |
| 0:18.0 | A few strands here, a little thinning there, and then one day it's gone. |
| 0:22.4 | Before you get wrinkled, before you start feeling tired, your hair starts whispering. |
| 0:26.6 | You're aging. |
| 0:28.2 | Is it hormones, genetics, or just a story that we've been told? |
| 0:32.3 | Because no one looked deeper. |
| 0:34.1 | Hair loss feels inevitable. |
| 0:35.7 | But what if one undiscovered molecule built in a longevity lab |
| 0:39.8 | could flip the switch? Dr. Carolina Reis Oliviera isn't from the beauty world. She's actually a |
| 0:46.2 | stem cell biologist with a PhD in immunology. She left Brazil for Silicon Belt to do something |
| 0:52.1 | radical, turn aging into a problem that science could |
| 0:55.3 | solve. She started by developing the first molecule proven to reverse skin's biological age. Now, |
| 1:01.9 | she's turning that same science toward your hair. And what she's uncovered changes everything. |
| 1:06.9 | I got to understand how much the science of aging has evolved in the past 10, 15 years. |
| 1:13.0 | Zombie cells, overlooked microbiomes, a new class of peptides that can restart hair growth, |
| 1:18.7 | no drugs, no side effects, no guesswork. |
| 1:21.7 | In a six-month clinical trial, 86% of users saw an average of 40% more hair density, thicker strands, revived follicles, |
| 1:31.3 | youthful growth, re-engineered from the root. This is a major breakthrough in one of the |
| 1:36.5 | hardest things to change in aging. And it starts where most people stop looking, your scalp. |
... |
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