Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 6 May 2025
⏱️ 68 minutes
🧾️ Download transcript
Summary
What if you could reverse the age of your heart...without leaving home?
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.
Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.
What You’ll Learn in This Episode:
• The link between mitochondrial decline and heart failure
• Why women’s cardiac risk skyrockets after menopause
• How Urolithin A stimulates mitophagy and energy renewal
• New human clinical data on reversing cardiac aging markers
• Biohacking strategies to fortify your cardiovascular health
• How to optimize endurance, recovery, and heart resilience
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Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Timeline Website – https://www.timeline.com/partners/dave-asprey
• Timeline Instagram - https://www.instagram.com/timeline_longevity/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 — Trailer
• 02:11 — Supplements that help
• 03:05 — Long-term benefits
• 04:38 — Stacking with lifestyle
• 22:19 — Heart health connection
• 29:39 — Mitochondria & brain function
• 33:04 — Glymphatic system & Alzheimer’s
• 33:53 — Bed height & brain health
• 34:18 — Why mitochondria matter
• 35:43 — Inflammation & dysfunction
• 38:12 — Transplants & consciousness
• 39:19 — Meditation’s effects
• 40:33 — The ultimate biohacking stack
• 43:06 — Creatine for sleep & focus
• 50:00 — Fertility insights
• 57:23 — Skin health
• 01:00:28 — Final thoughts
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Transcript
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| 0:00.0 | My view on longevity and cognitive performance is all about mitochondria. |
| 0:04.1 | Fix the mitochondria. Everything is better because they're foundational. |
| 0:07.1 | Irrespective of what cell or organ, you repair the mitochondria, you can rejuvenate them. |
| 0:12.5 | We have an army of amazing mitochondrial scientists, and they started looking at basically hearts of people who died of heart failure. |
| 0:19.4 | You can sequence them out. And they saw so |
| 0:22.1 | much mitochondrial damage in these hearts. You think fatigue is normal. You think muscle loss is aging. |
| 0:28.4 | You think low energy is your fault. It's not. It's your mitochondria. When your mitochondria |
| 0:33.8 | collapse, your strength disappears, your mind slows, your future narrows, and for women, it hits even harder. |
| 0:41.3 | New research shows that apra menopause, mitochondrial decline accelerates. |
| 0:45.3 | You lose muscle, your energy crashes, and you age from the inside out. |
| 0:50.3 | But it's not a death sentence, it's just a setback, and it's reversible. Dr. Anurag Singh leads the world |
| 0:57.9 | in fixing what breaks first, yourself. What we see in humans, if we really study it at the |
| 1:03.7 | molecular level, the molecule induces mitophagy, so cleans out the faulty mitochondria, and in about a month, |
| 1:08.9 | we start seeing what we called mitochondrial biidences. |
| 1:11.2 | His research uncovered a lost process, something we once triggered naturally, a way to clear |
| 1:16.8 | broken mitochondria, a way to rebuild the energy at the cellular level, a way to slow aging |
| 1:22.1 | out of the source. He didn't invent it, nature did, and now we can bring it back. A molecule, born from the right foods, rare inside the human body, and almost impossible to make naturally. |
| 1:34.6 | But this isn't an ad. It's a roadmap. A way to rebuild your energy, your strength, your future. |
| 1:40.5 | If you rejuvenate mitochondria, of course your heart is going to improve because it has |
| 1:46.3 | the second highest mitochondrial density of anywhere in the body. The second place would be neurons |
| 1:51.2 | in the brain. What is the average age of onset from mitochondrial decline in humans? To the best of |
| 1:56.2 | our knowledge. Energy cannot be created or destroyed, but it can be reclaimed. |
... |
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