Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Welcome to this week’s Midlife Minute. Today, I’m focusing on all the questions I received about gallbladder health, including HRT-provoking symptoms, supplements that improve gallbladder health, and evidence-based food interventions. IN THIS EPISODE, YOU WILL LEARN: Why the risk of gallstones and gallbladder inflammation increases during the menopause transition How estrogen and progesterone HRT have different effects on gallbladder functioning The differences in risk between transdermal and oral HRT How the progesterone in HRT can cause gallbladder issues in some women What TUDCA is, and how it supports gallbladder health The value of TUDCA for women who have had their gallbladders removed How various nutrients and supplements support bile flow and gallbladder health What can contribute to gallstone formation Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Gallbladder Research: Cabrera D, Arab JP, Arrese M. UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications. Seminars in Liver Disease. 2019;39(4):397–404. doi:10.1055/s-0039-1696799  Vang S, Longley K, Steer CJ, Low WC. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Global Advances in Health and Medicine. 2014;3(3):58–69. doi:10.7453/gahmj.2014.017  Bai M, Yang L, Liao H, et al. Tauroursodeoxycholic acid improves nonalcoholic fatty liver disease by regulating gut microbiota and bile acid metabolism. Journal of Agricultural and Food Chemistry. 2024;72(41):22655–22668. doi:10.1021/acs.jafc.4c04630  Simon JA, Hudes ES. Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. *Archives of Internal Medicine.*1999;159(6):619–624. doi:10.1001/archinte.159.6.619  Walcher T, Haenle MM, Kron M, et al. Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population. BMC Gastroenterology. 2009;9:74. doi:10.1186/1471-230X-9-74  Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term intake of dietary fiber and decreased risk of cholecystectomy in women. American Journal of Gastroenterology. 2004;99(7):1364–1370. doi:10.1111/j.1572-0241.2004.30281.x  Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology. 2002;123(6):1823–1830. doi:10.1053/gast.2002.37085  Moerman CJ, Smeets FW, Kromhout D. Dietary risk factors for clinically diagnosed gallstones in middle-aged men — a 25-year follow-up study. Annals of Epidemiology. 1994;4(3):248–254. doi:10.1016/1047-2797(94)90099-x Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma. Lipids in Health and Disease. 2024;23(1):82. doi:10.1186/s12944-024-02074-4  Pitt HA, Doty JE, Murphy MM, Schwarz MB. Progesterone alters biliary flow dynamics. Annals of Surgery. 1999;229(2):205–209. doi:10.1097/00000658-199902000-00008

Transcribed - Published: 4 June 2026

I am delighted to reconnect with Dr. Nicole LePera today. Trained in clinical psychology, she is a holistic psychologist whose work explores the interconnections among the mind, body, and soul, incorporating holistic lifestyle and psychological wellness practices. She has written multiple New York Times bestselling books, most recently Reparenting the Inner Child. In today’s conversation, we unpack what the inner child really means from a clinical perspective. We explore how understanding your childhood wounds intellectually differs from truly re-parenting yourself at the nervous system level, and how perimenopause and menopause influence the way we view the world. We look at ACE scores and the biology of childhood adversity, how ACE scores measure what happened to us, but fail to measure resilience, protective factors, or the capacity for healing. We examine how reactive parents shape our nervous system, and how that shows up as hypervigilance, emotional scanning, and self-erasure, and how the fawn response can lead to chronic people-pleasing, relentless accommodation, and an inability to say no. We also cover how epigenetics and lifestyles influence behavioral patterns, critical parenting, stress addiction, gut-brain dysregulation, and the disruptive effects of vagal tone gadgets. This is truly one of those must-listen conversations! I love Dr. LePera’s grounded and practical approach to helping people work through their childhood experiences and advocate for themselves. IN THIS EPISODE, YOU WILL LEARN: How childhood wounds become stored in the nervous system rather than just the mind Why understanding your dysfunctional habits intellectually will not change the emotional patterns that drive them How perimenopause and menopause can magnify unresolved emotional patterns What ACE scores measure and what they fail to capture How reactive parenting can lead to hypervigilance and emotional scanning, even in safe environments Dr. LePera describes the fawn response and explains how children learn to over-accommodate others, suppress their own needs, and avoid conflict. How chronic stress becomes a learned response, and how stress responses can be passed across generations   How chronic stress and a dysregulated nervous system can influence gut function and microbiome balance Why it’s essential to return your attention to your body in the present moment to begin healing Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Nicole LePera Website Social media platforms: @The Holistic Psychologist  Self Healers Circle (Membership community) Purchase a copy of Dr. Pera’s latest book, Reparenting the Inner Child.

Transcribed - Published: 3 June 2026

Today, I am excited to welcome you to the eagerly awaited third installment of Ask Me Anything!  In this episode, I shine a spotlight on a universal challenge that affects the lives of countless women over 35 as I delve into the heart of the problems of weight-loss resistance, plateaus, and the notorious belly fat that seems to cling for dear life.  The flood of questions that keep pouring in speaks volumes and is a testament to the exasperation we all feel! Join me on a journey to navigate that landscape, unravel the mysteries, confront misconceptions, and uncover strategies to overcome, decode, and dismantle the common issue of shedding those unwanted, stubborn pounds! I urge all of you, particularly those older than 35, to know you are not alone in your struggle! Stay tuned for the treasure trove of insights that awaits! IN THIS EPISODE YOU WILL LEARN: Why should you know what your fasting insulin is?  The importance of stress management Helpful supplements for those who have had their gallbladders removed How to deal with cravings and weight gain during the week before your period The first thing to work on if you are struggling with plateaus or weight loss resistance The importance of mitigating stress Managing your macronutrients The loss of muscle as we get older Physical activity and weight loss How important is body set weight?  How trauma impacts weight loss resistance Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcribed - Published: 1 June 2026

I’m delighted to connect with Dr. Eboni Cornish today. She is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society, specializing in complex chronic illness with expertise in brain health, Lyme disease, autoimmune conditions, mold exposure, gut dysfunction, and women’s midlife health. In our conversation, we explore how perimenopause and menopause affect the brain, as well as the roles of genetics and epigenetics. Dr. Cornish explains limbic lock, SPECT imaging, the impact of tick-borne illnesses, and co-infections, and how brain health issues can influence mental health. We also dive into the role of mold in testing, the gut-brain-immune-hormone axis, vagal tone, the estrobolome, leptin, the MTHFR mutation, and how Dr. Cornish prefers to have it tested and treated in her patients. Stay tuned for an insightful and wide-ranging conversation on brain health and women’s midlife wellness. IN THIS EPISODE, YOU WILL LEARN: Why women may experience brain fog, forgetfulness, and cognitive slowing as estrogen declines How declining estrogen could make the brain more vulnerable to toxins, infections, and leaky brain How disrupted sleep, poor nutrition, and lack of oxygen (from issues like sleep apnea) can negatively affect cognition and brain health The value of continuing to learn and staying socially connected to support your cognitive health as you age How genetics can help to identify women who may be at higher risk for cognitive decline later in life. What limbic lock means How toxin overload, mold, Lyme disease, and co-infections, and unresolved stress can create a state of limbic lock  How SPECT imaging helps to explain why some people fail to improve despite multiple treatments The benefits of progesterone for supporting relaxation and improving sleep during perimenopause How declining estrogen and gut dysbiosis during perimenopause can affect the gut-brain axis Bio: Dr. Eboni Cornish Dr. Eboni Cornish is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society. She specializes in complex chronic illness, with expertise in brain health, Lyme disease, autoimmune conditions, mold toxicity, gut dysfunction, and women’s midlife health. Known for her NeuroLongevity framework, Dr. Cornish takes a root-cause, brain-first approach to helping patients optimize cognitive resilience, hormone balance, and long-term wellness. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Eboni Cornish Amen Clinics On her website Instagram

Transcribed - Published: 30 May 2026

Welcome to the latest Midlife Minute. I’ve been getting many questions about viruses, bacterial vaginosis, and recurrent infections. So, today, I’m stepping a little outside our usual topics to explore how changes in the gut microbiome can directly influence the vaginal microbiome. Join me as I clarify what actually happens in the body during perimenopause and menopause, and explain why those shifts matter more than most women realize. IN THIS EPISODE, YOU WILL LEARN: Three changes that occur simultaneously during perimenopause and menopause, and how those changes increase our susceptibility to viruses like herpes. Why declining estrogen weakens the vaginal microbiome How gut microbiome changes in midlife affect the ability to recycle estrogen via the estrobolome Why the gut barrier becomes less stable and more permeable during perimenopause and menopause, and how that can trigger immune responses and low-grade inflammation How hormonal fluctuations can trigger viral outbreaks and increase the likelihood of shingles What research shows about hormone replacement therapy and lower rates and recurrence of severe herpes simplex infections Why bacterial vaginosis is becoming more common in midlife How to balance and support the gut and vaginal microbiome in midlife Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Links: 1. Menopausal shift on women’s health and microbial niches 2. The Effect of Menopause on the Innate Anti-Viral Activity of Cervicovaginal Lavage https://pmc.ncbi.nlm.nih.gov/articles/PMC4519412/  3. Spotlight on the Gut Microbiome in Menopause: Current Insights 4. Shingles and Menopause: Is There a Connection? 5. The Impact of Hormonal Replacement Therapy on Herpes Simplex Infection and Gingival Health in Post-Menopausal Women  6. The Menopause Transition, Vaginal Health, and Your Vaginal Microbiome 7. Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections: Review Article 8. G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo 9. Association between Acquisition of Herpes Simplex Virus Type 2 in Women and Bacterial Vaginosis  10. Recalcitrance of bacterial vaginosis among HSV-2 seropositive women

Transcribed - Published: 28 May 2026

I am thrilled to connect with Dr. Julia Haffner today. She’s a European-trained medical doctor who has worked in internal medicine, geriatrics, family practice, chronic pain therapy, esthetics, and hair transplant surgery, where she continuously saw patients struggling with symptoms their bodies were desperately trying to communicate, yet testing failed to provide answers. Today, we explore where stress lives in the body and why midlife can feel so different for women. We discuss the connection between postpartum experiences and perimenopausal symptoms, the nervous system’s relationship with fascia as a sensory organ, and how fascia responds to our personal experiences. We also examine trauma as highly bio-individual, lifestyle changes to support the nervous system during midlife, and how perimenopause impacts our adrenals. Dr. Haffner shares how she prefers to advocate for patients within the medical system, and talks about her app, which is free and available for listeners. We also cover how social media and technology influence our stress levels, Dr. Haffner’s meridian-related energetic facelift, and how our emotions connect to our bodies.  Stay tuned for today’s fascinating and insightful conversation with the delightful Dr. Julia Haffner, who also has a book coming out late this year. IN THIS EPISODE, YOU WILL LEARN: The similarity between postpartum low-estrogen and perimenopausal symptoms How doctors often focus only on measurable lab data while overlooking nervous system dysregulation and chronic stress Dr. Haffner describes fascia as a sensory organ How Dr. Haffner learned to recognize patterns of tension, stress, emotional overwhelm, and physical trauma within the fascia Why trauma is not limited only to major events like war or abuse  Why women tend to become more sensitive to stress, relationships, and environmental pressures as their estrogen declines The value of gentler workouts in midlife to support stress reduction and nervous system regulation without increasing cortisol Why years of chronic stress can leave women feeling depleted during perimenopause  How constant scrolling can contribute to low-grade stress within the body Dr. Haffner introduces her menopause symptom tracking app Bio: Dr. Julia Haffner Dr. Julia Haffner is a European-trained medical doctor who worked across internal medicine, geriatrics, family practice, chronic pain therapy, aesthetic medicine, and hair transplant surgery — and kept seeing the same thing: bodies crying out for help that no test could hear. Life took her to Italy with her second daughter, where she discovered the ability to feel into any part of the body and sense what's stored there — a memory, a grief, a fear still frozen in the fascia decades later. What most people call limiting beliefs or self-doubt isn't a mind problem. It's stored in the body. In the tissue. In the fascia. And it stays there until someone helps it release. Over 1,000 remote sessions later: cancer in remission, chronic pain dissolved, self-doubt cleared from the body, the spark returning. She is the creator of the Energetic Facelift. Her message: You are your own best doctor. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Julia Haffner On her website Dr. Haffner’s book, The State Before the Bite: Secrets of the Secret, will be released in late 2026

Transcribed - Published: 27 May 2026

I am happy to connect with Dr. William Li today! He is a world-renowned physician, scientist, speaker, and author. He is known for leading the Angiogenesis Foundation, and his groundbreaking work has impacted more than 70 diseases. He is also a Ted-X speaker and the author of Eat to Beat Your Diet, one of my favorite books thus far this year.  Dr. Li’s latest book is about what happens in the body, how it should operate, and the steps we can take to restore it to its hard-wired state. We dive into how body fat impacts our health, the role of metabolism throughout our lifetime, the differences between the three fat-impacting hormones, including leptin, adiponectin, and resistin, and gender differences. We speak about new drugs like Ozempic and Semaglutide, the role of brown fat, the impact of the microbiome and specific bacteria, and nutrition and lifestyle. IN THIS EPISODE YOU WILL LEARN: Why Dr. Li chose this time to write his latest book  Is 60 the new 20? The four stages of metabolism hardwired into each of us  How excess body fat derails metabolism, and how can we unleash our inner metabolism Why is it better to eat slowly? Why should we learn to respect and tame our fat instead of hating or fearing it? Dr. Li shares his views on new prescription drugs like Ozempic and Semaglutide. Interesting facts about body fat Changes that occur in our body fat distribution as we get older How can we help our bodies fight excess body fat, bring our inner metabolism to the surface, and reduce inflammation by being aware and mindful? Modern-day lifestyle choices and metabolic disease Dr. Li discusses the interplay between the gut microbiome and metabolism, as well as the role of Akkermansia.  Some everyday foods contain natural chemicals that can activate our body’s defenses, tame metabolism, and fight body fat. BIO William W. Li, MD, is an internationally renowned physician, scientist, and New York Times bestselling author of the forthcoming book “Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, Live Longer”. His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases, including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, LIVE with Kelly and Ryan, and the Rachael Ray Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is the president and medical director of the Angiogenesis Foundation. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. William Li On his⁠ website⁠ Social media: @DrWilliamLi Dr. William Li’s latest book, ⁠Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, and Live Longer⁠ is available from most bookstores.

Transcribed - Published: 25 May 2026

Today, I’m thrilled to connect with Dr. Jordan Emont. He is a board-certified OB-GYN with specialty training in menopause medicine, integrative hormonal care, and sexual health, and is one of fewer than 5,000 physicians worldwide who hold the Menopause Society-certified practitioner designation. In this conversation, we unpack the fear narrative surrounding HRT and clarify the distinctions between estrogen, progesterone, and cancer risk. We explore the impact of the Women’s Health Initiative and discuss why rigid dogmatism has no place in women’s health, the risks associated with early menopause and premature ovarian insufficiency, individual risk stratification, and contraindications to HRT. We also examine the connection between gut health and colorectal cancer, metabolic health as a modifiable cancer risk, and the emotional side of middle age and hormone replacement therapy. Stay tuned for one of the most important and thought-provoking conversations we’ve ever had on the podcast. IN THIS EPISODE, YOU WILL LEARN: How fears about hormone therapy are often based on outdated or misinterpreted data The difference between physiologic hormones and synthetic hormone formulations How the Women’s Health Initiative's messaging that HRT causes breast cancer comes from an oversimplification of data How the fear-driven WHI headlines continue to impact women's and clinicians’ thoughts about hormone replacement therapy  How women’s concerns about menopause, sexual health, and menstrual symptoms are often dismissed The health risks associated with early menopause and premature ovarian insufficiency How declining estrogen levels affect multiple body systems, including gut-related and immune-related pathways Why is insulin resistance a major concern?  True contraindications for avoiding HRT Bio: Dr. Jordan Emont Dr. Jordan Emont is a board-certified OB/GYN and Menopause Certified Practitioner who specializes in menopause care for women who’ve been dismissed, undertreated, or told their symptoms are just part of aging. He’s here to change that conversation. He trained at Yale, Brown, and Columbia, and is now an adjunct clinical faculty member at Stanford. He works at a community health center in the Bay Area, providing care to underserved populations, and runs his own private telehealth practice focused on complex menopause care. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Jordan Emont On his website Instagram and Substack

Transcribed - Published: 23 May 2026

Welcome to today’s Midlife Minute. Today, we’re exploring bloating, constipation, and various other midlife gut woes.  Stay tuned as I clarify how midlife changes the gut narrative and review the evidence about how to get things moving again. IN THIS EPISODE, YOU WILL LEARN: Why your gut motility changes in midlife How menopause influences the gut-brain connection Why various types of constipation require different interventions How changes in your gut bacteria affect the way your gut functions in menopause How different types of fiber can either help or worsen constipation symptoms, depending on the type of constipation  The main types of constipation, and how they differ  How estrogen therapy may influence bowel regularity, and why the route of administration matters Lifestyle habits that can stimulate bowel movements Why bloating tends to occur in midlife Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Links: 1. Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos 2. The Intestinal Microbiome and Estrogen Receptor–Positive Female Breast Cancer  3. Estrogen–gut microbiome axis: Physiological and clinical implications 4. Menopausal shift on women’s health and microbial niches 5. Gut microbiota has the potential to improve health of menopausal women by regulating estrogen 6. Gut-microbiota-targeted diets modulate human immune status 7. Effect of female sex hormone supplementation and withdrawal on gastrointestinal and colonic transit in postmenopausal women 8. Constipation and diarrhea during the menopause transition and early postmenopause: observations from the Seattle Midlife Women’s Health Study 9. Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice 10. Rome IV Criteria 11. Gut-Directed Hypnotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis  Gut-Directed Hypnotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis (PubMed) 12. Randomised clinical trial: the efficacy of gut-directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome 13. Gut-directed hypnosis and hypnotherapy for irritable bowel syndrome: a mini-review 14. Review article: gut-directed hypnotherapy in the management of irritable bowel syndrome and inflammatory bowel disease

Transcribed - Published: 21 May 2026

I am delighted to connect with Sachin Patel today. Sachin is a father, husband, philanthropist, functional medicine practice success coach, speaker, author, breathwork facilitator, and plant medicine advocate. He is passionate about helping people activate their “inner doctor” through lifestyle medicine, breathwork, and greater self-awareness. Having had the privilege of knowing Sachin both personally and professionally, what stands out most is his unwavering commitment to helping people better understand their physiology so they can heal more effectively and live more intentionally. In today’s conversation, we explore the connection between the autonomic nervous system, the vagus nerve, and overall health. Sachin shares insights on breath dynamics, diaphragm function, coherent breathing, CO₂ tolerance, the Bohr effect, the physiologic sigh, and the often-overlooked role of repressed emotions in physical well-being. We also discuss the importance of nature, circadian rhythms, sunlight, temperature regulation, and Sachin offers his recommendations for women in midlife and beyond. I also highly recommend his new book, Breath, Balance, and Burn, which was recently released. Stay tuned for a fascinating conversation on breath, healing, and the daily habits that shape how we feel, function, and age. IN THIS EPISODE, YOU WILL LEARN: How spending too much time in fight-or-flight mode prevents the body from entering a healing state How women’s multiple roles and chronic stress, combined with midlife hormonal transitions, can create a “perfect storm” of sympathetic dominance and nervous system dysregulation How your breath reflects your emotional state  Why healing becomes difficult when the body remains in a fight-or-flight state The benefits of coherent breathing for oxygen delivery and nervous system regulation How the diaphragm serves as an access point to emotional regulation and nervous system control How our breathing patterns and nervous system state can influence the emotional state of others Sachin outlines practical techniques to help regulate stress, improve focus, increase energy, and prepare for sleep How modern indoor living disconnects people from their natural rhythms Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Sachin Patel On Facebook On Instagram On YouTube – The Living Light Reset Get instant access to The Breathe, Balance, Burn Training Program and Breathwork Bundle Purchase a copy of Sachin’s Book, Breathe, Balance, Burn: How Fixing the Way You Breathe Resets Your Stress Hormones, Shrinks Your Belly, and Gives You Back the Energy and Calm You Thought Were Gone for Good, on Amazon.

Transcribed - Published: 20 May 2026

Today, I am honored to connect with Dr. Mary Claire Haver, a board-certified OBGYN who has dedicated her entire adult life to championing women's health.  Dr. Haver is the visionary creator of the Galveston Diet, the first and only nutrition program ever designed by a female OBGYN for menopausal women.  In our conversation today, Dr. Haver shares her background, and we discuss her new book, The Galveston Diet. We examine the glaring systemic gap where the health of middle-aged women remains undervalued and underfunded in research, and our discussion touches on various facets of women's health, including perimenopausal symptoms, the distinction between chronological and endocrine aging, the scientific misconceptions surrounding weight gain and hormones, the advantages of intermittent fasting, inflammation, and macros. We also get into the supplements Dr. Haver finds beneficial for women in middle age, as well as the impact of non-nutritive sweeteners and the role of continuous glucose monitors. IN THIS EPISODE YOU WILL LEARN: Dr. Haver highlights various symptoms of perimenopause How menopause can increase health risks How muscle loss with aging can make women more insulin resistant and lead to cardiovascular changes How the hormonal changes that occur during perimenopause and menopause can impact weight management What are the benefits of intermittent fasting for perimenopausal women? How a combination of genetics and lifestyle factors can help women prepare for menopause and manage its symptoms How sugar, alcohol, and gluten impact inflammation, insulin levels, and blood sugar How a lack of protein and the wrong types of fats can lead to hunger and satiety issues and lead to muscle breakdown and weight gain in menopausal women Dr. Haver talks about her book, The Galveston Diet How do non-nutritive sweeteners impact the gut microbiome and blood sugar levels? The benefits of using a continuous glucose monitor to track blood sugar levels Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Mary Claire Haver ⁠Website⁠ ⁠Instagram⁠ ⁠TikTok⁠ ⁠YouTube⁠ ⁠Order a copy of The Galveston Diet.⁠

Transcribed - Published: 18 May 2026

Today, I have the honor of interviewing Dr. Doris Day, a board-certified dermatologist who specializes in cosmetic and longevity dermatology. She is also a clinical professor of dermatology at NYU, recognized for her dedication and excellence in teaching, and is widely regarded as a leader in the aesthetic dermatology field. In addition to her clinical work, Dr. Day is a medical journalist and a prominent media figure. In our discussion, we examine the basics of perimenopause and menopause from a pathophysiology perspective, including the 30% decline in collagen synthesis that occurs during the first five years of menopause. We explore the skin microbiome, inflammation, and inflammaging, and why hydration, electrolytes, reducing processed sugars, and eating a nutrient-dense diet can have such a visible impact on skin health. Dr. Day also explains her approach to facial balancing and how our bones, fascia, muscles, and fat pads age. We discuss topical agents, advanced interventions including lasers, microneedling, PRF, PRP, stem cells, and growth factors, and even touch on emerging research suggesting that certain laser treatments may help reduce the risk of skin cancer. Throughout the conversation, I also openly shared what I have done to support my skin. Stay tuned for today’s fascinating conversation about menopause, skin health, collagen loss, and the evolving science behind modern aesthetic dermatology. IN THIS EPISODE, YOU WILL LEARN: The sudden skin changes many women experience during early perimenopause Dr. Day explains how she personalizes skincare routines for each patient How collagen synthesis rapidly declines during the menopause transition How hydration, sleep, and nutrition can visibly improve skin tone and puffiness How inflammation, blood sugar issues, and poor metabolic health contribute to inflammaging and visible skin aging Why facial balance is more important than trying to erase every wrinkle or line Dr. Day shares how she combines lasers, topicals, and recovery protocols to support skin healing and collagen production How fillers and other cosmetic procedures can create an unnatural appearance when used incorrectly Bio: Dr. Doris Day, MD, is a board-certified dermatologist specializing in cosmetic and longevity dermatology. She is a Clinical Professor of Dermatology at NYU Langone Health, where she has been recognized with the Award for Dedication and Excellence in the Teaching of Dermatology. Her leadership in aesthetic dermatology has earned her the AAD Presidential Citation and the American Skin Association Award for leadership in dermatology. Ranked #3 in the United States and #1 in New York by Newsweek as a Top Cosmetic Dermatologist, Dr. Day is a recognized authority in her field. Her work has been cited in leading publications, including The New York Times and Castle Connolly’s NY Magazine Top Doctors listings, for over 20 consecutive years. Dr. Day is also a medical journalist and a prominent media figure, providing expert commentary on major television programs and podcasts. Her insights are regularly featured in top magazines, and she is a sought-after speaker, delivering numerous lectures every year on cutting-edge aesthetic techniques at both national and international conferences. Dr. Day has over 100 publications in the medical literature, and she has written four best-selling books: "Rebooting the Biome" (2023), "Beyond Beautiful" (2018), "Forget the Facelift," and "100 Questions and Answers about Acne." She also hosts a popular dermatology show on SiriusXM’s Doctor Radio, a platform where she has been educating the public for over 15 years, earning the AAD’s Golden Triangle Award for Media Excellence. Her professional affiliations include the American Society for Dermatologic Surgery, where she has served on the board of directors; the American Academy of Dermatology, where she was recently elected to the nominating committee; the New York State Dermatology Society; and the American Honors Society of Dental and Facial Aesthetics. Dr. Day earned her BA in English from Columbia University, an MA in Journalism and Science Writing/Medical Reporting from New York University, and her MD from SUNY Downstate College of Medicine. She completed her dermatology residency at Cornell University College of Medicine, where she served as Chief Resident. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Doris Day On her website Instagram, Facebook, and TikTok

Transcribed - Published: 16 May 2026

Welcome to the latest Midlife Minute. This week, we have a data-rich, sleep-focused masterclass episode for middle-aged women. Drawing on research, physiology, and my own perspective, I connect the dots between hormones, circadian rhythm, and lifestyle habits, highlighting the areas you need to pay attention to. IN THIS EPISODE, YOU WILL LEARN: How sleep actively supports growth, immune function, and skeletal and muscular performance Why people who don’t sleep well tend to be more emotionally charged How, second to hot flashes, insomnia is one of the most commonly reported symptoms of perimenopause and menopause How REM sleep differs from non-REM sleep Why sleep is essential for brain detoxification How the suprachiasmatic nucleus controls circadian rhythm Why sleep quality tends to decline in midlife How poor sleep disrupts metabolic health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcribed - Published: 14 May 2026

Today, I’m delighted to reconnect with nutritionist, Andrea Donsky. Andrea is a well-respected media personality, speaker, author, researcher, and host of the Menopause Reimagined podcast, on which I have been a guest twice. In our conversation, we discuss her new book and speak at length about her motivation for writing about nourishment for mind, body, and spirit. We explore why food suddenly feels like it’s working against you, and why our nutrition truly needs to change in midlife. We cover symptom-specific nutrition, including a detailed discussion of hot flashes, the importance of fiber, and navigating weight-loss resistance as a Gen X-er. We also talk about the weight and shame imprinting that many of our generation experienced, followed by a rapid-fire conversation around magnesium, protein, alcohol, and more. Join us for today’s transparent, honest, and real conversation with Andrea Donsky.  Andrea’s book, Nourishing Menopause: Powerful Nutrition and Lifestyle Strategies to Feel Your Best, will be published in May. IN THIS EPISODE, YOU WILL LEARN: Why Andrea took a mind, body, and spirit approach to nourishment in her book Andrea shares her experience of gaining and losing weight in midlife, despite making no changes to her diet or exercise routine How perimenopause can go unrecognized for years—even for a nutritionist Why what worked before may no longer work in midlife, and how Andrea had to relearn how to eat, exercise, and think  The lack of education and stigma that shaped the Gen X menopause experience Why balancing blood sugar becomes foundational in midlife The link between insulin resistance and factors like stress, poor sleep, diet, visceral fat, and hormonal changes  How undereating can worsen weight-loss resistance Andrea shares her “balance blueprint” for blood sugar in midlife Bio: Andrea Donsky Andrea Donsky is a nutritionist, 7X Published Menopause Researcher & Entrepreneur with 26 years of experience in health and wellness. She is a respected multi-award-winning influencer, media personality, speaker, and author. Andrea hosts the podcast “Menopause Reimagined,” and she is the co-founder of www.wearemorphus.com, a company that empowers women to feel heard and supported as they go through perimenopause and menopause. Her book, Nourishing Menopause: Powerful Nutrition and Lifestyle Strategies to Feel Your Best, published by Simon and Schuster, is out now. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Andrea Donsky On her website Order Andrea’s new book, Nourishing Menopause. On TikTok and Instagram We Are Morphus on Instagram

Transcribed - Published: 13 May 2026

I am honored and delighted to have Vanessa Spina join me on the podcast today!  Vanessa is the best-selling author of Keto Essentials and a sports nutrition specialist whose expertise on the ketogenic diet has left a lasting impact on countless lives! With a background in biomedical science and a multifaceted career as an international stockbroker, she has pioneered a journey in the health and wellness industry that is nothing short of remarkable!  In this episode, we dive deep into the fascinating realm of nutrition, from unraveling the mysteries of protein-recommended daily allowances and the leucine threshold to exploring the pivotal role of strength training in metabolic health. We dispel common misconceptions about the ketogenic diet, debunk the deceptive nature of the scale, and unveil the significance of DEXA scans in understanding changes in body composition. Vanessa also sheds light on the crucial importance of mitochondrial health and shares invaluable insights on various methods, including red light therapy, cold thermogenesis, micronutrients, and structured supplementation, to support our cellular powerhouses.  Join Vanessa and me on a knowledge-rich journey to uncover the keys to optimal health and well-being! IN THIS EPISODE YOU WILL LEARN: Common misconceptions about ketogenic diets Why a traditional ketogenic diet is not for everyone Why macronutrients are essential Misinformation regarding the recommended daily allowance for protein How to build muscle The relationship between metabolic health and muscle health The importance of DEXA scans for understanding body composition Why resistance training is a priority How to support the mitochondria The benefits of red light therapy and cold therapy Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Vanessa Spina On her ⁠website⁠ (ketogenicgirl.com) ⁠The Optimal Protein Podcast⁠ Vanessa’s Book ⁠Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight ⁠ Resource: Use Code CYNTHIA for $20 OFF any of the Tone ⁠LUX devices⁠.

Transcribed - Published: 11 May 2026

Today, I’m delighted to connect with Dr. Paul Reynolds, whom I was honored to meet at an event last year. He is a professor of cell biology and physiology at Brigham Young University. In our discussion, we explore inflammation, how it changes with aging, and how muscle serves as both an endocrine and a metabolic organ. We unpack glucose physiology, how it drives inflammation in the body, and examine the effects of glycation and the changes it causes in our eyes, immune systems, nerves, skin, and bones. Dr. Reynolds explains his “rules” for glucose balancing and the benefits of micro-dosing with GLP-1s, or starting with a minimal dose and increasing it slowly. We also discuss cravings and gender differences in men and women, and share practical strategies that everyone can use. I am looking forward to recording another podcast episode with Dr. Reynolds later this year, when his new book comes out. IN THIS EPISODE, YOU WILL LEARN: Chronic inflammation as the root of many modern health issues Muscle loss with aging and its link to inflammation and glycation How excess glucose fuels free radicals, glycation, and inflammation What glycation is and why it damages the body Lifestyle habits that disrupt glucose balance and drive inflammation Supporting natural GLP-1 through diet and lifestyle Fasting and smart carb intake for insulin sensitivity Menopause, autoimmunity, and chronic disease risk Long-term consequences of glycation for the eyes, skin, bones, immune system, and nerves Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Paul Reynolds On X, Instagram, and YouTube

Transcribed - Published: 9 May 2026

Welcome to this week’s Midlife Minute, where we’re taking a closer look at sleep—one of the most frequently asked-about topics. Stay tuned as I walk through the science, the hormones, and the everyday habits that can make or break your sleep quality, especially in midlife. IN THIS EPISODE, YOU WILL LEARN: Various risk factors for poor sleep How consistently getting less than 5 hours of sleep increases the risk of obesity What actually happens in each stage of sleep How circadian receptors throughout the body influence sleep and metabolism How eating late at night disrupts melatonin, cortisol, and digestive circadian rhythms Why melatonin is far more than just a sleep hormone Reasons why sleep becomes more challenging for women in perimenopause and menopause Lifestyle, nutrition, and supplement strategies that can improve sleep quality Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcribed - Published: 7 May 2026

Today, I am thrilled to reconnect with my friend and colleague, Dr. Amie Hornaman, also known as the Thyroid Fixer. She is the founder and CEO of the Advanced Thyroid and Hormone Clinic, host of the Thyroid Fixer podcast, and a sought-after speaker and author. In today’s conversation, we discuss her brand-new book, The Thyroid Fix, and explore the current thyroid-related silent epidemic. We dive into mitochondrial dysfunction, thyroid optimization, and the significance of reverse T3, also unpacking the symptoms that impact your digestion and hypothyroidism, environmental triggers, oral contraceptive use, and how it increases your susceptibility and risk for developing hypothyroidism. We also examine natural desiccated thyroid, the effects of iodine supplementation, and Dr. Hornaman shares her top three lifestyle strategies for a healthy thyroid. This is a truly insightful and helpful conversation, especially for those in my community who are struggling with an underactive thyroid- myself included. Stay tuned for more. IN THIS EPISODE, YOU WILL LEARN: How women with hypothyroidism are often misdiagnosed or medically gaslit Why Dr. Hornaman believes that the actual number of Americans with hypothyroidism may be far higher than current statistics suggest What reverse T3 is and why it increases when we are stressed How thyroid function impacts the way that cells produce energy How a low-functioning thyroid can slow digestion and cause constipation Why do some women require more personalized thyroid treatment than standard T4 therapy? How environmental toxins can disrupt thyroid health Why long-term oral contraceptive use could increase the risk of hypothyroidism Some simple lifestyle habits and biohacks to improve stress resilience in women with thyroid dysfunction Bio: Dr. Amie Hornaman Dr. Amie Hornaman, known as The Thyroid Fixer, is the founder of the Advanced Thyroid and Hormone Clinic and host of the top-rated podcast The Thyroid Fixer. She is the author of the thyroid bible, The Thyroid Fix, the last thyroid book you’ll ever need to understand fatigue, fogginess, and stubborn weight. Driven by her own experience with misdiagnosis, Dr. Amie helps people optimize their thyroid, reclaim their health, and step fully into the badass humans they were meant to be. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Amie Hornaman On her website Pre-order a copy of The Thyroid Fix

Transcribed - Published: 6 May 2026

I am delighted to reconnect with Esther Blum today. She joined me once before for Episode 264, one of the most popular podcast episodes for 2023.  Esther is the bestselling author of many books, including See You Later Ovulator. She is a registered dietitian with a thriving virtual practice specializing in helping women balance their hormones, shed stubborn body fat, and address the root causes of their health issues. Today, Esther and I discuss the state of hormones in 2024. Our conversation covers lazy medicine advocacy, meno-washing, and meno-care, and we explore uncommon symptoms associated with perimenopause and menopause, as well as methods for obtaining testing. Esther also shares her recommended supplements.  You will love this engaging and insightful conversation with Esther Blum! IN THIS EPISODE YOU WILL LEARN: How safe is hormone replacement therapy? Why hormone testing and monitoring is essential  The importance of prioritizing romance and connection in a marriage The benefits of pelvic floor therapy How working with compounding pharmacies can reduce the cost of hormone replacement therapy How to work with doctors to address hormone imbalances Some uncommon symptoms of perimenopause and menopause How dietary changes and probiotics can improve focus and brain clarity  Hormone testing and menopause management  Esther recommends supplements for adrenal support during menopause Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Esther Blum On her ⁠website⁠ ⁠Instagram⁠ Get Esther’s ⁠14-Day Metabolic Menopausal Meal Plan⁠  Esther’s Books ⁠Esther’s book, See Ya Later, Ovulator!⁠, by Esther Blum ⁠Cavewomen Don’t Get Fat⁠, by Esther Blum ⁠Eat, Drink, and Be Happy⁠, by Esther Blum Previous Episode featuring Esther Blum ⁠Ep. 264 Peri/Menopause are a Natural Function of Aging: See you later, Ovulator!⁠

Transcribed - Published: 4 May 2026

Welcome to today’s masterclass episode featuring metabolic health and GLP-1 experts Dr. Nick Norwitz, Dr. Rocio Salas-Whalen, Dr. Alexandra Sowa, PA-C, McCall McPherson, and registered dietitian, Ashley Koff, sharing their expert perspectives. In today’s masterclass, our experts share insights into appetite regulation and satiety, the importance of digestion, the impact of statins on insulin sensitivity, and key limitations in the research. We take a closer look at GLP-1 medications, proper prescribing practices, personalized dosing, and the value of targeted, individualized nutrition strategies. We also separate fact from fiction when complications arise. Join our experts as they break down how to safely and effectively maximize the benefits of GLP-1 therapy. IN THIS EPISODE, YOU WILL LEARN: The value of combining GLP-1s with other medications and lifestyle tools for optimal results How taking time to pause helps women reconnect with their bodies and shift from mindless eating to mindful nourishment  Dr. Nick Norwitz highlights that patients are often not given the information needed for proper informed consent around statins. How statins can reduce natural GLP-1 levels and negatively impact metabolic health  How GLP-1 medications work to reduce hunger and prevent snacking between meals Common side-effects of GLP-1 medications, and how they can be mitigated How hair loss can occur with weight loss, and how that can be managed The importance of clinical guidance for monitoring the side effects of GLP-1 use  The benefits of microdosing with GLP-1s Why it’s essential for hunger not to be entirely suppressed when taking GLP-1s  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Alexandra Sowa On her website On all social media: @dralexandrasowa Purchase a copy of Dr. Sowa’s book, The Ozempic Revolution Connect with McCall McPherson Modern Thyroid Clinic On Instagram and TikTok Modern Thyroid and Wellness Podcast Thyroid Lab Guide Connect with Dr. Nick Norwitz On YouTube, X, and Instagram Substack Connect with Dr. Rocio Salas-Whalen On her website On social media: @drsalaswhalen Dr. Rocio’s Book, Weightless Connect with Ashley Koff The Better Nutrition Program On Instagram and Substack Social media: @Ashley Koff Podcast Links: Ep. 438 The Rise of GLP-1s: Key to Weight Loss & Metabolic Health with Dr. Alexandra Sowa Ep. 478 Thyroid Truths: Labs, Adrenals & Appetite Explained with McCall McPherson Ep. 525 We’ve Been Misled About Metabolic Health – The Shocking Truth About Cholesterol, GLP-1 & Aging with Dr. Nick Norwitz Ep. 534 The Hidden Forces Making Women Gain Weight – The Shocking Truth About Hormones, Trauma & GLP-1s with Dr. Rocio Salas-Whalen Ep. 562 “It’s Not a Willpower Problem” – Why Women’s Bodies Resist Weight Loss in Midlife with Ashley Koff, RD

Transcribed - Published: 2 May 2026

Welcome to another episode in our Midlife Minute Series. Today, I’ll be exploring weight loss resistance and how you may be unknowingly disrupting your hormones during perimenopause and menopause. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: Why  the concept of calories in, calories out is outdated How sleep, stress, and sarcopenia drive weight loss resistance in midlife Why under-eating protein and over-consuming processed carbohydrates become more problematic in middle age Why increasing your protein intake without consuming enough fiber can cause gut issues Why constant snacking and poor food quality compound metabolic dysfunction How dysbiosis adds to weight loss resistance, poor metabolic health, and sleep disruption How everyday exposure to toxins contributes to inflammation, oxidative stress, and insulin resistance, and disrupts hormone signaling Why perimenopause becomes a “litmus test” for how well we take care of ourselves Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcribed - Published: 30 April 2026

We have an estrogen masterclass mashup episode today, featuring Dr. Carrie Jones, Dr. Stephanie Estima, Dr. Sarah Berry, Dr. Thomas Dayspring, and Dr. Kellyann Niotis, who share their insights on estrogen and women’s health in midlife. In this mashup masterclass, we’re bringing together a powerful compilation of conversations centered on the impact of hormones on brain health and cognition. We explore the nuanced risk factors for neurocognitive changes and how shifts in insulin sensitivity during perimenopause and menopause influence various aspects, including lipid patterns, hair changes, laboratory markers, and lifestyle inputs. We examine how the gut microbiome changes dynamically, targeted nutritional interventions, the role of advanced testing, including the DUTCH test, and how genetics, detoxification pathways, methylation, and the estrobolome. This is an exciting, dynamic mashup of some of my favorite podcast conversations dedicated to estrogen and midlife physiology. It’s one you’ll likely want to revisit more than once. IN THIS EPISODE, YOU WILL LEARN: The critical role estrogen plays neurologically, and how estrogen receptors in the brain increase as estrogen declines How declining estradiol during menopause impacts women's lipid metabolism Why insulin resistance tends to increase during the menopause transition The gut microbiome shifts that occur in postmenopausal women The link between the gut microbiome and menopausal symptoms such as brain fog, anxiety, and sleep issues How impaired estrogen detoxification pathways may increase long-term risk of hormone-sensitive cancers How the DUTCH test provides insight into hormone patterns and metabolism beyond standard bloodwork How declining estrogen disrupts the hair growth cycle and increases shedding Why personalized approaches to supplements, diet, and HRT are essential for women in midlife Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Carrie Jones On Instagram Estrogen Detox Made Easy Hello Hormones with Dr. Carrie Jones (Podcast) Connect with Dr. Stephanie Estima On Instagram Better! With Dr. Stephanie (Podcast) Connect with Dr. Sarah Berry On Instagram The Zoe Science and Nutrition Podcast Connect with Dr. Thomas Dayspring On LinkedIn On X (@DrLipid) Connect with Dr. Kellyann Niotis On her website On Instagram Podcast Links: EP. 513 Fasting Doesn’t Work the Same After 35 – The Shocking Truth About Hormones, Hunger & Aging with Dr. Stephanie Estima Ep. 522 Menopause Is Wrecking Your Gut – The Best Nutrition Fixes for Midlife Women with Dr. Sarah Berry Ep. 523 This Is Why Your Cholesterol Shifts in Midlife – The Best Strategies to Reduce Risk & Improve Vascular Health with Dr. Thomas Dayspring | Women’s Heart Health & Menopause Ep. 540 “Your Brain Needs Estrogen” – The Most Powerful Way to Protect Memory, Cognition & Longevity in Midlife with Dr. Kellyann Niotis | Menopause & Brain Health Ep. 542 Why Your Hair Is Thinning After 40” – The Shocking Truth About Menopause Hair Loss – Cynthia Thurlow Ep. 567 “Timing Is Everything” – The Best Way to Test Hormones, Cortisol & Thyroid for Real Answers with Dr. Carrie Jones

Transcribed - Published: 29 April 2026

I am delighted to connect with Shawn Stevenson today! Shawn is the host of the prolific Model Health Show. He is also a Nutritional Scientist, an author, and a father. Shawn was a top-tier athlete in high school. At fifteen, his hip broke while running a 200-meter time trial. He had some standard of care, but nobody ever asked how an apparently healthy kid broke his hip while running. Two years later, he went to college. Soon after that, he got diagnosed with degenerative disc disease.    In this episode, we get into how his background influenced his career path. We discuss fast-food economies, ultra-processed foods, the impact of subsidized foods on our health, the gut microbiome, and the dangers of seed oils. We dive into metabolic switching, the vagus nerve, and how it impacts food absorption and leaky gut. We talk about brain health, how the brain is influenced by the food we eat, the interrelationship between the brain and metabolic health, insulin sensitivity, and the impact of inflammation on the brain. We also discuss the importance of hydration, electrolytes, and more. IN THIS EPISODE YOU WILL LEARN: How Shawn developed his passion for discussing nutrition and synthesizing research, and got to where he is today. How changing his thinking changed his life. What are ultra-processed foods? How ultra-processed foods impact the health of the average American citizen. Why so many Americans are obese today The need to understand the connection between the brain and the gut. What is the relationship between our immune system and our gut microbiome? An unusual benefit of extra-virgin olive oil. What can you do to have a healthier brain? The critical importance of high-quality sodium for cognitive function. Why Omega-3s are vital for our brains. Bio: Shawn Stevenson is the author of the USA Today National bestseller Eat Smarter and the international bestselling book Sleep Smarter. He’s also the creator of The Model Health Show, which is featured as the #1 health podcast in the U.S., with millions of downloads each year. A graduate of the University of Missouri–St. Louis and Shawn studied business, biology, and nutritional science and became the cofounder of Advanced Integrative Health Alliance. Shawn has been featured in Forbes, Fast Company, The New York Times, Muscle & Fitness, ABC News, ESPN, and many other major media outlets. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Shawn Stevenson On his ⁠website⁠ ⁠The Model Health Show⁠ On ⁠Facebook⁠, ⁠Instagram⁠, ⁠YouTube⁠, and ⁠Twitter⁠ Shawn’s books are available on ⁠Amazon⁠.

Transcribed - Published: 27 April 2026

Today, I am honored to welcome Dr. Karen Corbin, an Associate Investigator and Obesity Program Lead at the AdventHealth Translational Research Institute, and the Founder and Chief Geek of Geeks That Speak. Her scientific career centers on human nutrition and metabolism, with a focus on uncovering the mechanisms behind individual susceptibility to metabolic diseases, including obesity, diabetes, and liver disease. A gifted scientific storyteller, Dr. Corbin founded Geeks That Speak to help scientists and fellow geeks communicate complex information in ways that are clear, compelling, and actionable. She joins us today to share her perspective on the gut microbiome and its role in women's aging. She discusses her background as a registered dietitian and research scientist, and we explore the fundamentals of the gut microbiome, metabolic health, fermentation, and metabolism, including specific metabolites such as short-chain fatty acids, bile acids, and postbiotics. We examine fiber as a critical fuel substrate, the research on its utilization, and the unique metabolic vulnerabilities women in midlife face. We also explore whether the microbiome drives insulin resistance, whether late-night eating becomes more disruptive after the age of 40, what’s overhyped versus underappreciated in the wellness space, and the latest thinking on GLP-1s, fecal transplants, dysbiosis, and more. Today’s conversation with Dr. Corbin is truly insightful and informative. Be sure to stay tuned all the way to the end, where she talks about upcoming research regarding a fiber-devoid diet and how protein can ferment in the colon. IN THIS EPISODE, YOU WILL LEARN: Dr. Corbin describes the colon as a dynamic ecosystem where microbes function like a community rather than the passive waste container it was once thought to be How the gut microbiome influences metabolism, immunity, and brain signaling How microbes directly influence calorie absorption and energy access What true fiber intolerance may signal Why gut health becomes increasingly important with hormonal shifts and aging How microbes and the body influence each other, impacting insulin sensitivity, metabolism, and energy use Why late-night eating becomes more metabolically disruptive as circadian rhythms and hormones shift with age How differences in metabolic pathways can cause the same foods or supplements to affect people in different ways Bio: Dr. Karen Corbin Karen Corbin, PhD, RD, is an Associate Investigator and Obesity Program Lead at the Advent Health Translational Research Institute and the Founder and Chief Geek of Geeks That Speak. Dr. Corbin’s scientific career focuses on human nutrition and metabolism. She explores the mechanisms, including the gut microbiome, that drive individual susceptibility to metabolic diseases such as obesity, diabetes, and liver disease. Her overall goal is to advance clinically relevant research poised to transform patient care. Dr. Corbin is also an expert in scientific storytelling. She founded Geeks That Speak to help scientists and other “geeks” deliver complex scientific information in a way that is impactful, relevant, and inspires action. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Karen Corbin On her website LinkedIn

Transcribed - Published: 25 April 2026

Welcome to today’s Midlife Minute. In this episode, I answer listeners’ questions about GLP-1 medications and midlife weight changes. I explore how hormonal shifts, insulin sensitivity, muscle mass, and the gut microbiome influence the effectiveness of these drugs, and explain why they should be regarded as part of a broader metabolic and lifestyle framework. IN THIS EPISODE, YOU WILL LEARN: Why GLP-1 medications don’t necessarily fix the root cause of midlife weight gain  How declining estrogen can disrupt your appetite and satiety hormones The value of checking your fasting insulin to understand your insulin sensitivity level How inadequate protein can cause cravings for processed carbohydrates and fats Why preserving muscle mass is critical to prevent sarcopenic obesity   How GLP-1 medications affect digestion and gut motility The clinical factors that are considered when prescribing GLP-1 medications  Some simple daily habits to support your metabolic and microbiome health when using GLP-1 medications  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcribed - Published: 23 April 2026

Today, I am delighted to reconnect with Caroline Alan, affectionately known as the Mineral Geek. Caroline is a health survivor, mineral expert, and educator on a mission to shift the way we think about cellular health. Her transformative experience sparked a deep dive into the science of minerals and human physiology. Caroline is the author of The Mineral Reset and Co-founder and CEO of Beam Minerals. In today’s discussion, Caroline shares her personal story of poor adrenal health in perimenopause. We explore the effects of plant-based minerals, the prevalence of mineral deficiencies in our modern-day lifestyles, and the impact of key stages in a woman's life, including menstruation, pregnancy, perimenopause, and menopause. We examine how macro- and micronutrient deficiencies are exacerbated by poor gut health, the value of humic and fulvic acids, and how humic and fulvic molecules can support the body at a foundational level and assist in balancing our health during perimenopause and menopause. We also discuss the circumstances and challenges women experience in middle age, and highlight some essential paradigm shifts to consider as we age. Caroline truly loves sharing this vital information with the world, so you certainly won’t want to miss today’s insightful conversation with her. IN THIS EPISODE, YOU WILL LEARN: How Caroline’s chronic health issues extended beyond mitochondrial dysfunction and hormone decline  The turning point Caroline experienced after introducing liquid minerals  Why are so many women currently experiencing mineral depletion? How nutrient density of produce has declined due to modern farming methods, making it difficult for us to meet our nutritional needs through diet alone Why filtered and purified water can contribute to mineral depletion. Minerals and how they support energy production and biosynthesis in the body How minerals are absorbed and used in the body Why the standard approach to supplementation often fails How poor gut health, heavy metals, and parasites can impede the proper utilization of minerals The value of humic and fulvic acids lies in their ability to help restore the body’s natural replenishment process. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Caroline Alan On her website On social media: @CarolineAlan.official  Beam Minerals (Discount Code: CYNTHIA) Beam Minerals Advanced Set

Transcribed - Published: 22 April 2026

Get ready to venture into the realm of cutting-edge health and nutrition as I reconnect with Kara Collier, a registered dietitian and the co-founder of Nutrisense, the revolutionary continuous glucose monitor app!  Our paths last crossed back in January of 2021, and I am thrilled to catch up with Kara again! Today, we delve deep into the ever-evolving landscape of metabolic health in 2023, exploring the pivotal role of CGM labs and glucometers in understanding our bodies.  In today’s captivating conversation, Kara unravels the significance of measuring glucose against other metabolites, unveiling the profound impact of macros, exercise, supplements, sleep quality, life stage, and bio-individuality on our well-being. With a wealth of invaluable hacks to optimize your blood sugar, we invite you to join us on a captivating journey that will empower you to take charge of your health and transform your life!  Gear up for an enlightening conversation packed with valuable insights you will not want to miss! Prepare to be inspired and informed as we uncover the secrets to unlocking your metabolic potential! IN THIS EPISODE YOU WILL LEARN: The current state of metabolic health What is leading to obesity in the US? Getting your fasting glucose value below 90 The pros and cons of glucometers Glucose monitoring and the 8020 rule Tracking your data to learn about yourself Hacks to improve your diet The role of movement in metabolic health How important is Zone 2 training for mitochondrial health?  Follicular versus luteal phase and insulin sensitivity The importance of protein and carbohydrates Blood sugar and sleep quality About Kara: Kara Collier is the co-founder and VP of Health at Nutrisense, one of America’s fastest-growing wellness-tech startups. After becoming frustrated with the shortcomings of the traditional healthcare system, she made it her mission to help others reach their maximum health potential using modern technology & expert coaching. She is the leading authority on the use of continuous glucose monitoring (CGM) technology for health optimization and disease prevention. Kara is a Registered Dietitian Nutritionist (RDN), Licensed Dietitian/Nutritionist (LDN), and Certified Nutrition Support Clinician (CNSC). Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Kara Collier On ⁠Instagram⁠  ⁠Nutrisense⁠ ⁠Ep. 132 – Continuous Glucose Monitors: Why They’re Not Just for Diabetics Anymore with Kara Collier

Transcribed - Published: 20 April 2026

Today, I’m excited to welcome Debra Atkinson back to the podcast for our third conversation. Debra holds both a BS and an MS in exercise science, with additional training in sports psychology, and served for many years as a senior lecturer in a university kinesiology program. She is a respected voice in the menopause space and an outstanding resource for personal training, coaching, and professional development for midlife women. In today’s discussion, we explore key nuances and emerging trends in the fitness industry, including insights from recent surveys conducted by the American College of Sports Medicine. We unpack why many midlife women are drawn to the wrong types of workouts and the downstream consequences of those choices. We also examine what happens as estrogen levels decline, particularly its impact on muscle protein synthesis, and how this increases the risk of injury and tendon and ligament damage. We dive into strategies for avoiding frailty, the effects of chronic under-fueling, how nutritional choices- especially sugar, alcohol, and underlying food sensitivities can exacerbate hot flashes and other symptoms, and the importance of VO₂ max. To wrap up, Debra answers a series of rapid-fire questions, ranging from the one exercise every woman over 40 should master to conversations around zone two training, vibration plates, weighted vests, and more. This conversation with Debra Atkinson is truly invaluable, and I know you’ll walk away with practical and empowering insights. IN THIS EPISODE, YOU WILL LEARN: Why social media exercise trends can often be misleading How habits, conditioning, and attachment to old exercise patterns impact women’s exercise choices  Why women’s injury risk increases as estrogen levels decline How travel, jet lag, and holiday foods can amplify stress and compound the risk of muscle loss Practical and proactive steps you can take to avoid losing independence as you age How chronic under-fueling disrupts women’s metabolism, recovery, and resilience in midlife The value of VO₂ max beyond cardiovascular fitness How grip strength functions as an early indicator of overall strength and neurological health The importance of daily, low-level movement for stabilizing blood sugar, cardiovascular health, and body weight How inadequate or disrupted sleep can negate the benefits of training programs Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Debra Atkinson On her website The Flipping 50 Podcast On Social Media: @flipping50tv

Transcribed - Published: 18 April 2026

Welcome to this week’s Midlife Minute episode. Today, I answer a question from a 55-year-old postmenopausal woman on HRT who still wakes up multiple times at night. I also explore the factors that tend to affect women’s sleep in midlife and offer practical strategies for better sleep. IN THIS EPISODE, YOU WILL LEARN: How sleep apnea shows up differently in women than it does in men Why being constantly sympathetic dominant may interfere with your sleep How not eating enough protein, healthy carbohydrates, fiber, and healthy fats can spike your cortisol overnight How drops in progesterone and changes in estrogen can impact GABA and glutamate The importance of doing vagal exercise during the day and gearing down before bed  Some simple vagus nerve practices to support relaxation How alterations in progesterone and estrogen impact neurotransmitters My favorite supplement for supporting sleep, and adaptogenic herbs that buffer cortisol Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Links: 1. Sleep and sleep disorders in the menopausal transition (Research Link) 2. The Sleep Goddess Reveals the Truth About Sleep, Menopause & Hidden Sleep Disorders | A. Matsumura (YouTube)  3. Pulsetto (Affiliate link): Discount code: CYNTHIA

Transcribed - Published: 16 April 2026

Today, I am honored to welcome Dr. Christopher Davis, a triple-board-certified physician in internal medicine, cardiology, and interventional cardiology, as well as a specialist in functional and regenerative medicine. He is also the Chief Cardiologist at Humann, a science-backed, plant-based heart health supplements company.  In our discussion, Dr Davis and I explore why women’s risk for heart disease accelerates after 40, how women’s physiology and anatomy make them more prone to small vessel disease, the challenges of our current medical model, and the impact of toxins. Dr. Davis shares the labs and imaging modalities he prefers, and highlights the need for personalized medicine. We examine cardiomyopathies in women, where takotsubo or broken heart syndrome originates, and how declining nitric oxide production during perimenopause and menopause affects vascular health. We also cover research on GLP-1s and their impact, the significance of nitric oxide production, the importance of endothelial health, and the glycocalyx. Today’s discussion is a must-listen for anyone seeking a deeper understanding of women’s heart health in middle age. IN THIS EPISODE, YOU WILL LEARN: Why women’s heart disease risk accelerates after 40 How toxins and xenoestrogens contribute to vascular stress and metabolic disruption What advanced labs and imaging can reveal beyond traditional testing Why women’s unique physiology makes them more vulnerable to small vessel disease How the glycocalyx and endothelial health protect the heart and circulation Why personalized medicine is essential Why cardiomyopathies like takotsubo are seen more frequently in women How nitric oxide production impacts vascular flexibility and overall cardiac health What research shows about the benefits of GLP-1s, beyond weight loss The value of the Goldilocks approach to supplements in personalized patient care Bio: Christopher Davis, MD, FACC Dr. Christopher Davis is triple board-certified in internal medicine, cardiology, and interventional cardiology and is a specialist in functional medicine, bioidentical hormone replacement, and regenerative medicine. He is the Chief Cardiologist at Humann, a science-backed, plant-based heart health supplements company. Dr.Davis has been honored as one of America’s “Top Doctors” by Castle Connolly Medical and has received the distinguished title of Top Doctor by U.S. News and World Report and Sarasota Magazine. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Christopher Davis Reveal Vitality On Instagram

Transcribed - Published: 15 April 2026

We’re excited to share another episode in our podcast series featuring heavily vetted companies. Today, I’m delighted to connect with Baran Dilaver. Baran is an entrepreneur, creator, and accomplished executive, and also the co-founder of Wonderfeel Biosciences, a longevity-focused bioscience company that pioneers cellular health innovations through its patented NAD products. (You will likely remember the dynamic interview I did last year with Dr. Andrew Salzman, the MD and Chief Medical Officer of Wonderfeel.) In today’s conversation, Baran and I explore the science of cellular energy and its wide-ranging benefits. We cover the physiology of NAD and other nutraceuticals, the key markers of inflammation, and the precursors in Wonderfeel’s formulas that enhance absorption and assimilation. We discuss how NAD and creatine monohydrate each fuel cellular energy, their powerful synergistic effects, and the NAD-creatine combination as a powerful midlife stack. We also get into brain fog, mood, and stress resilience, along with the FDA’s clarification on NMN and other nutraceuticals, and why NAD injections and IV NAD may fall short compared to oral precursors like NMN and NR. I also share my experience trying Wonderfeel’s newest product, Choco Creatine. You won’t miss this in-depth conversation with Baran Dilaver of Wonderfeel, as he shares his expert perspective on NAD and creatine monohydrate supplementation. IN THIS EPISODE, YOU WILL LEARN: What recent research from Harvard and MIT has shown about the benefits of increasing NAD levels Why NAD is so essential Baran describes how reduced NAD affects each organ differently How inflammation becomes a key signal of declining NAD levels Why precursors like NMN and NR are necessary for increasing intracellular NAD levels What led Baran to explore how to make NAD compounds more accessible to consumers? How NAD and creatine work synergistically to improve brain and gut functioning How compromised gut integrity drains our energy and forces the body into “overdrive.” Baran outlines the complexities of product development Why ingredients like resveratrol and hydroxytyrosol are included in the Wonderfuel NAD formula Bio: Baran Dilaver Baran is an entrepreneur, creator, and an accomplished executive. He is the Co-founder of Wonderfeel Biosciences, a longevity-focused biosciences company that pioneers cellular health innovations through its patented NAD products. Previously, he led numerous start-ups successfully, served as CEO and COO at public and private companies, where he collaborated with top scientists, visionaries, and medical experts, and developed award-winning products. He is a frequent speaker at conferences like Tech Open Air, Wonderland, and Brandweek. At UC Berkeley, he studied economics and earned athletic and academic scholarships. He gets a special thrill from enhancing people’s lives with the products he helps innovate. Baran has been leading the NAD and longevity related initiatives at Wonderfeel Biosciences as its Co-founder and CEO, co-writing a number of patent applications, in vitro and in vivo studies, collecting consumer feedback and helping the Wonderfeel medical team publish peer reviewed papers and by participating high profile interviews and podcasts with the likes of Dr. Mark Hyman and Dave Asprey and speaking at conferences like the Biohacker Summit. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Baran DilaverWebsite: https://getwonderfeel.com/  Wonderfeel Youngr™ NMN product page⁠:⁠ ⁠Between April 15 and April 30, listeners can receive a travel size Youngr™ NMN pouch ($22 value) with their first order using the code CYNTHIATHURLOW (US orders only) Previous Episode Mentioned BONUS: Why NAD Matters for Women’s Health & Hormones

Transcribed - Published: 13 April 2026

I am delighted to welcome Dr. Felice Gersh for part two of our conversation on progesterone, brain health, and cognition. Dr. Gersh is a valued colleague, friend, and mentor. She is a board-certified OBGYN in integrative medicine. She taught at the USC Keck School of Medicine for 12 years and is the founder and director of the Integrative Medical Group of Irvine. Today, we continue our conversation by exploring the liver's role in detoxification, dosing, and alternative routes of administration for progesterone. We cover the effects of allopregnanolone, the timing hypothesis, how to optimize hormones during perimenopause and menopause, the impact of cycling hormones in menopause, optimal estradiol levels, progesterone intolerance, and paradoxical effects. We also discuss growth factors in estrogen cycling, mitochondrial health and inflammation, how shift work disrupts circadian rhythms, and immune system changes in menopause. This is a conversation you will definitely want to revisit. Dr. Gersh truly challenged my thinking about hormone therapy with her simple but powerful message about the importance of considering the bigger picture when it comes to hormone replacement therapy. IN THIS EPISODE, YOU WILL LEARN: How reproductive hormones influence cognition, mood, and focus The cognitive changes, brain fog, and memory lapses that occur during menopause How allopregnanolone, progesterone’s metabolite, can either support calm and sleep or potentially accelerate cognitive decline over time How different routes of progesterone administration (oral, vaginal, rectal) produce very different outcomes Dr. Gersh challenges the assumption that static hormone dosing aligns with the evolution of female physiology.  How localized symptoms act as indicators of what could be happening in the brain, bones, and cardiovascular system The benefits of using progesterone in cycles rather than continuously How estradiol and progesterone decline in menopause can lead to low-grade inflammation, shifts in immune function, and reduced mitochondrial efficiency How shift work disrupts circadian rhythms Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com. Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Felice Gersh On YouTube and Instagram The Integrative Medical Group of Irvine

Transcribed - Published: 11 April 2026

Welcome to this week’s Midlife Minute episode. Today, I respond to a complex question from my free Facebook group.  Stay tuned as I explore the root cause of Melinda’s persistent knee inflammation, from protein needs and recovery to mitochondrial support, and why eating “clean” does not always reduce inflammation. IN THIS EPISODE, YOU WILL LEARN: How persistent swelling and discomfort after 40 could reflect mitochondrial decline Why 20 to 25 grams of protein at a meal may not be enough to trigger muscle protein synthesis Why eating “really clean” while doing heavy exercise could create a relative energy deficiency Mitochondrial support supplements that are commonly used for repair and boosting mitophagy The benefits of the flavonoid, apigenin The value of CoQ10, especially for those on statin therapy Why melatonin is more than just a sleep hormone How BPC 157 differs from the experimental peptides available online Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Link: Troscriptions  - https://troscriptions.com/discount/CYNTHIA10

Transcribed - Published: 9 April 2026

I’m thrilled to connect with Dr. Natalie Crawford today. She’s a double-board-certified fertility doctor and the author of The Fertility Formula. Unlike most other physicians, she blends lifestyle and functional medicine with science-based facts, aiming to help women conceive and understand their bodies. While this conversation may not feel fully aligned with the perimenopause and menopause transition, I encourage you to listen with an open mind to what Natalie shares about hormones. In our discussion, we explore fertility as a vital sign, the impact of infertility, and why one in six women experiences infertility. We break down ovarian reserve and the realities of aging. We also cover specific labs that can help assess ovarian reserve and overall health. We explain DOR and POI, the overlap between fertility and perimenopause, and why the ovaries can behave like a “cranky toddler” in perimenopause. Finally, we dive into the role of the gut microbiome in estrogen metabolism and inflammation, and discuss IVF, egg freezing, modern reproductive options, lifestyle influences, and a series of rapid-fire questions. Dr. Crawford’s book, The Fertility Formula, is a must-read for women of all ages. It contains many valuable insights, and I love the way she blends an integrative approach with an allopathic approach for her patients. IN THIS EPISODE, YOU WILL LEARN: How fertility serves as a health marker that reflects a woman’s hormonal, cellular, and metabolic health The role of inflammation in infertility Dr. Crawford clarifies ovarian reserve, highlighting the importance of understanding egg quality and quantity. Why AMH testing is the most informative first step for women concerned about their fertility Dr. Crawford outlines three factors that can cause missed or irregular periods. The importance of tracking ovulation and understanding the body's signals during perimenopause Inflammation and aging can disrupt chromosome alignment and impair embryo development. How poor estrogen clearance and gut microbiome imbalances disrupt brain-ovary signaling and ovulation timing The link between sleep deprivation and low sperm counts, and how stress and lack of muscle mass can drive insulin resistance and inflammation Why sleep, muscle mass, and stress reduction are all essential for fertility It’s essential to approach fertility proactively, and to know how to do that. Bio: Natalie Crawford Natalie Crawford, MD, is board-certified in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility and is co-founder of Fora Fertility, a boutique fertility practice in Austin, Texas. Dr. Crawford is CEO and co-founder of Pinnacle, a professional network for women in medicine. She completed her undergraduate degree at Auburn University, obtaining a degree in Nutrition Science, Medical School at UTMB, OBGYN Residency at UTSW, and REI Fellowship at UNC, concurrently obtaining a Master of Science in Clinical Research. Dr. Crawford is a digital health educator on social media, YouTube, and hosts the podcast  “As a Woman” with over 6 million downloads. Her debut book, “The Fertility Formula”, will be released by Penguin Random House.  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Natalie Crawford On her website On social media: @NatalieCrawfordMD Dr. Crawford’s book, The Fertility Formula, is available here.

Transcribed - Published: 8 April 2026

I am thrilled to have my friend and colleague, Debra Atkinson, back on the show today. She was with me before for Episode 165, in August of 2021, which became one of the most sought-after episodes of the year.  Debra is a hormone-balancing exercise coach, a fitness expert, and an influential figure who has guided more than 275,000 women through transforming their second halves with newfound vitality and energy. She is also an accomplished author, the host of Flipping 50 TV, and a TEDx speaker. In our conversation today, we delve into the physiological changes during perimenopause and menopause that impact weight training and muscle development, and we explore how to shift into the second stage of life as an endurance athlete while promoting recovery. We discuss the importance of strength training during perimenopause and menopause, and get into the role of volume, movements, zone 2 training, flexibility, and HiT. We also discuss biohacking, explain how hormone replacement therapy impacts muscle and bone health, and Debra shares her favorite supplements. IN THIS EPISODE YOU WILL LEARN: The physiologic changes that impact muscle health during perimenopause and menopause The challenges of transitioning from an endurance athlete to a menopausal woman How Debra struggled with hormonal imbalances and inflammation during menopause Some common exercise mistakes during perimenopause and menopause Why recovery time between weight training sessions is essential The importance of breathing and pelvic floor exercises  The benefits of HiT training for women in midlife At which times during the menstrual cycle should strength training be done? Strength training and bone health for post-menopausal women  The advantages of doing high-impact exercises on most days of the week The merits of vibration training and infrared saunas for recovery and wellness Supplements for muscle gain and recovery Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Debra Atkinson On her ⁠website⁠   YouTube⁠ ⁠Instagram⁠, ⁠Facebook⁠ Previous Episode Mentioned ⁠Ep. 165 – A Fresh Perspective On Menopause & Fitness: The Importance of Listening to Your Body with

Transcribed - Published: 6 April 2026

I am delighted to connect with Dr. Tricia Pasricha today. She is a gastroenterologist specializing in neurogastroenterology, a physician scientist at Beth Israel Deaconess Medical Center, and an Assistant Professor of Medicine at Harvard Medical School. In our conversation, we discuss her new book, You've Been Pooping All Wrong, which is truly delightful and a definite must-read. We explore the science of poop, and the stigma surrounding it, how stress impacts motility, the gastrocolic reflex, and what is considered normal, regarding pooping frequency. Dr. Pasricha explains how she addresses travelers’ constipation, and we also dive into women's issues specific to perimenopause and menopause, the effects of dyssynergia, red flags that concern her, and the symptoms and causes of early colorectal cancer, in addition to my rapid-fire menopause gut addition. Today’s discussion with Dr. Tricia Pasricha is truly invaluable. She is both smart and accessible, and I know you'll enjoy our conversation. IN THIS EPISODE, YOU WILL LEARN: Why women tend to be more inhibited about their bodily functions than men The gut-brain connection and how stress can affect bowel movements What is normal when it comes to bowel frequency? The importance of treating both the central and enteric nervous systems to manage IBS symptoms Why fiber is essential, and various ways to incorporate it into meals How fiber improves bowel regularity and overall health Common issues women experience with bowel movements during perimenopause and menopause The role of pelvic floor dysfunction in constipation and how it can be treated Dr. Pasricha identifies three red flags for serious health conditions The potential link between environmental factors, increased consumption of ultra-processed foods and sugar-sweetened beverages, and early onset colorectal cancer. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Trisha Pasricha On Instagram Dr. Pasricha’s book, You’ve Been Pooping All Wrong, will be released on April 7th. Pre-order now! https://www.trishapasricha.com/youvebeenpoopingallwrong

Transcribed - Published: 4 April 2026

Welcome to this week’s Midlife Minute, and the final episode in our three-part series on fiber. Bloating in middle age is a very common concern for women. Stay tuned as I explain how to address that and clarify how to increase your fiber intake without bloating. IN THIS EPISODE, YOU WILL LEARN: Why fiber is crucial for women in perimenopause and menopause How declining estradiol negatively impacts the gut microbiome Why soluble fiber becomes especially important as insulin sensitivity decreases in midlife Why many women tend to bloat when increasing their fiber consumption Strategies to increase your fiber intake gradually The importance of proper hydration The gold standard for fiber intake Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Download Cynthia’s 10 Fiber-Rich Carbohydrates that Support Midlife Metabolism List HERE. Research Links Relation of Dietary Fat and Fiber to Elevation of C-Reactive Protein Cholesterol-Lowering Effects of Dietary Fiber: a Meta-Analysis The Effect of Fiber on Satiety and Food Intake: a Systematic Review The Emergence of the Metabolic Syndrome with Menopause The Effect of Dietary Fat and Fiber on Serum Estrogen Concentrations in Premenopausal Women Under Controlled Dietary Conditions From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease Dietary Fiber and Body Weight

Transcribed - Published: 2 April 2026

Today, I am honored to connect with Dr. Dominik Nischwitz, a German dentist, pioneer of biological functional dentistry and ceramic implantology, founder of DNA Aesthetics, and the Vice President of the International Society for Metal-Free Implantology. He's also an author with a particular focus on how optimal health starts in the mouth. In our discussion, Dr. Nischwitz explains why the oral microbiome is, in fact, the upper gut. We explore the impact of oral dysbiosis, hormonal changes in oral health, concerns about root canals, cavitations, and old wisdom tooth sites. We clarify that mercury amalgams are not benign and are known neurotoxins, and explain why big-mouth overhauls must be carefully planned. We also discuss the debate of fluoride versus hydroxyapatite, cosmetic dentistry concerns, and more. This is another invaluable conversation that you will likely want to listen to several times. IN THIS EPISODE, YOU WILL LEARN: Dr. Nischwitz explains the oral microbiome What is dysbiosis? How changes in estrogen and nitric oxide production affect the gums and oral tissues Dr. Nischwitz explains why he believes that conventional dentistry is outdated, and highlights the benefits of biodentistry Why so many people fear dentists The risks associated with root canals How cavitations can become infected and lead to chronic inflammation and other health issues Why mercury in dental fillings is so dangerous The importance of having mercury fillings removed safely by a certified biological dentist Why is hydroxyapatite safer than fluoride? Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Dominik Nischwitz On his website Instagram

Transcribed - Published: 1 April 2026

Today, I have the honor of connecting with Dr. Robynne Chutkan, one of the most recognizable gastroenterologists in the United States. She is also the author of Anti-Viral Gut, one of the books I enjoyed reading most in 2022! Knowledge of the microbiome dates back to the 1600s when Anthony van Leeuwenhoek observed bacteria in his dental plaque through a microscope. However, it has taken us several centuries to understand the interdependence and beneficial nature of those bacteria. The terms "microbiome" and "microbiota" are often used interchangeably. They refer to the organisms and genes that live in and on our bodies, predominantly in the GI tract. Those organisms include bacteria, viruses, protozoa, fungi, parasites, and archaea, which, despite their microscopic size, collectively weigh about 4 to 5 pounds.  Today, Dr. Chutkan and I dive deep into the physiology of the microbiome and discuss how that interplays with immunology. We discuss the benefits of hydrochloric acid, the impact of proton pump inhibitors and other medications on gut microbiome health, and the role of dysbiosis and the Estrobolome. We get into how the pharmaceutical industry has influenced both medical practice and the outlook of healthcare providers, and we talk about the impact of sleep, exercise, stress, and alcohol on the gut. Dr. Chutkan also shares top tips from her anti-viral diet book for supporting the gut. (One of her tips is to consume 30 plant types per week for a healthier gut microbiome.)  This show has been one of my favorite podcasts that I have recorded in the last year. I hope you enjoy listening to it! IN THIS EPISODE YOU WILL LEARN: What is the microbiome, and why is it important? Why do we need to understand the interrelationship between the oral microbiome, the gut microbiome, and the vaginal microbiome? The importance of stomach acid. How do proton pump inhibitors affect gut health? The three big things that interfere with digestion. How pharmaceutical companies have taken over medical education. The role of statins in women. Importance of the Estrobolome test. Three different types of estrogens in the body. Why exercise is an important contributor to gut health. The net impact of low-quality sleep on immune function. Dr. Chutkan shares her top tips for a healthy gut microbiome. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Robynne Chutkan  On her ⁠website⁠  Instagram⁠ (@gutbliss) Books by Dr. Robynne Chutkan: ⁠The Anti-Viral Gut: Tackling Pathogens from the Inside Out⁠ ⁠Gutbliss: A 10-Day Plan to Ban Bloat, Flush Toxins, and Dump Your Digestive Baggage⁠ ⁠The Bloat Cure: 101 Natural Solutions for Real and Lasting Relief⁠ ⁠The Microbiome Solution: A Radical New Way to Heal Your Body from the Inside Out⁠ Books mentioned: ⁠Why We Sleep: Unlocking the Power of Sleep and Dreams by Matthew Walker⁠

Transcribed - Published: 30 March 2026

I am thrilled to connect with Dr. Lindsey Berkson today. The audacious and tenacious Dr. Berkson is a distinguished hormone scholar from the highly praised Center for Bioenvironmental Research at Tulane. She is the author of 21 books, and her impact on medical literature continues to grow. With her thoughtful manner and infectious enthusiasm for learning, she educates women about their bodies and health. Our discussion today highlights the importance of supporting the hippocampus and doing targeted cardiovascular exercise. We explore hormone replacement therapy, the timing hypothesis, and why oxytocin is more than just a bonding hormone. We cover endocrine-disrupting chemicals, detoxification, gut health, inflammation, and ways to support immunity, and we examine how oxytocin influences digestion, gut motility, and gut-brain access. We also explain how oxytocin protects our stem cells, prevents gut trauma after colonoscopies, reduces gut inflammation, and supports healthy transit time. Dr. Berkson’s new book, The Oxytocin Medicine, is truly an incredible resource and one I will reference often. It is most inspiring! IN THIS EPISODE, YOU WILL LEARN: How a shrinking hippocampus alters women’s identity and resilience The value of cardio-respiratory fitness and pushing limits for driving resilience How conservative hormone dosing may fail to protect women’s health in perimenopause and beyond Women’s Health Initiative messaging created a widespread fear of estrogen. Why Dr. Berkson challenges the timing hypothesis  The difference between synthetic progestins and naturally made progesterone Oxytocin and how it functions as a system-wide hormone Importance of detoxification during the perimenopause to menopause transition  Consistent patterns are common among women who age with physical and cognitive resilience. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Lindsey Berkson On her website Substack The Oxytocin Medicine

Transcribed - Published: 28 March 2026

Welcome to this week’s episode of the Midlife Minute. This is the second episode in our three-part series, focusing on the vital role of fiber in midlife. Stay tuned as I explore the connection between fiber, hormones, and blood sugar, clarifying how midlife tends to reframe the rules. IN THIS EPISODE, YOU WILL LEARN: How hormonal changes in midlife can lead to shifts in body composition Why fiber is essential for stabilizing blood sugar and insulin levels  The role fiber plays in fat distribution How fiber helps the body handle estrogen Signs that can indicate you are not consuming enough fiber  Practical tips for increasing your fiber intake The importance of proper hydration Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Research Links Relation of dietary fat and fiber to elevation of C-reactive protein Cholesterol-lowering effects of dietary fiber: a meta-analysis The effect of fiber on satiety and food intake: a systematic review The emergence of the metabolic syndrome with menopause The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease Dietary fiber and body weight

Transcribed - Published: 26 March 2026

I am thrilled to welcome Dr. Nick Trubee today. He is an exercise physiologist and Certified Strength and Conditioning Specialist with more than 17 years of experience, and a former university professor who now coaches clients online, focusing on preventing and reversing osteoporosis through resistance and impact training. In our discussion, we dive into why bone and muscle loss accelerate after 40, common misconceptions about walking or light activity being enough to build bone, and the spectrum of risk factors that contribute to bone loss. Dr. Trubee shares his take on reframing osteopenia and osteoporosis, clears misconceptions around exercise and progressive overload, and explains how often we need to train to build strength while minimizing injury risk. We look at the importance of training intensity and Zone Two workouts, and why nutrition and protein intake are essential for more strength and better bone health, also exploring meal timing, weighted belts, vests, and weights, how grip strength reflects overall strength, the effects of vibration plates and infrared saunas, and the importance of mindset and delayed gratification for long-term bone and muscle health. This conversation with Dr. Nick Trubee is truly invaluable. It's one you will definitely want to come back to. IN THIS EPISODE, YOU WILL LEARN: The benefits of consistent use of vibration plates, red light, and sauna for recovery and nervous system support Why you should avoid pushing through a full workout when you are feeling run-down or depleted How much protein should we be eating? Current guidelines may fall short of the actual protein requirements for people over 60 The value of creatine for muscle and bone support Why many women over 40 struggle with their body composition  A tip to help you meet your protein requirements How weighted vests can boost metabolism while safely enhancing bone strength Why grip strength is a proxy for overall strength  Bio:  Dr. Nick Trubee is an Exercise Physiologist (PhD, University of Kentucky) and Certified Strength & Conditioning Specialist (CSCS) with over 17 years of experience. A former university professor, he now coaches clients online, focusing on osteoporosis prevention and reversal through resistance and impact training.  Nick has worked with a wide range of people—from athletes and first responders to adults with osteopenia and osteoporosis—helping them rebuild strength, confidence, and trust in their bodies. He stays on top of the latest research in exercise science to ensure his clients receive safe, effective, and evidence-based training.  His philosophy is simple: every workout should leave you feeling better than when you started. By combining his academic background with practical coaching, Nick empowers clients to build strong bones, resilient bodies, and a life without limits. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Nick Trubee On his website Instagram Fitness Lit Breakdown Podcast

Transcribed - Published: 25 March 2026

Today, I’m delighted to connect with Wade Lightheart, a certified sports nutritionist advisor and the president/director of education and co-founder of BIOptimizers. Wade is a three-time national natural bodybuilding champion who came out of retirement at 50 to win the Open Men’s and Grand Master’s Categories at the INBA Ironman International competition. In our conversation, we explore how modern lifestyle habits affect sleep, digestion, mood, and overall metabolic health, as well as the often-overlooked role of magnesium in supporting the nervous system, energy production, and restorative sleep. We also share some practical ways to improve your digestion, stabilize your blood sugar levels, and rebuild your nutrient reserves. Stay tuned for today’s insightful and informative discussion with Wade Lightheart, the co-founder of BIOptimizers. IN THIS EPISODE, YOU WILL LEARN: The role of magnesium in sleep physiology How sleep chronotypes shape our unique sleep requirements How current lifestyle factors can contribute to magnesium depletion and increased nervous system activation The connection between low magnesium levels and issues with mood, stress tolerance, and sleep How our enzyme secretion and digestive processes become disrupted when we are constantly in fight-or-flight mode Digestive issues that could indicate low stomach acid or enzyme deficiencies How hormonal changes during perimenopause can influence women’s digestive processes How protein and fiber help to slow carbohydrate absorption and support more stable blood sugar levels How nutrient depletion tends to happen gradually, not all at once Bio:  Wade T. Lightheart is a Certified Sports Nutritionist Advisor, president/director of education, and co-founder of BIOptimizers. As a plant-based, drug-free athlete for more than two decades, Wade is a three-time National Natural Bodybuilding Champion who, by age 31, competed in both the IFBB Mr. Universe and the INBA Natural Olympia. At the age of 50, Wade came out of retirement to win the Open Men’s and Grand Master’s Categories at the INBA Ironman International, then competed at the PNBA Natural Olympia. Six months later, Wade successfully ran his first marathon in four hours. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Wade Lightheart Bioptimizers-use the code CYNTHIA15 for 15% off On Facebook, Instagram, and YouTube The Ultimate Nutrition Bible

Transcribed - Published: 23 March 2026

I’m thrilled to have Dr. Felice Gersh join me for a two-part conversation focusing on menopause and HRT. She is a prolific voice in the integrative gynecology space, a true mentor, and someone I respect enormously. In the first part today, we dive into progesterone and its wide-ranging systemic effects. We unpack the differences between synthetic and bioidentical hormones, discuss the Women's Health Initiative, examine the role of progesterone in cardiovascular disease, and look at the importance of nitric oxide production. We explore ovarian senescence and how we accelerate our ovarian aging. Dr. Gersh explains how declining nitric oxide production relates to aging and shares ways to achieve optimal health during menopause. We also discuss how PCOS impacts fertility and longevity, how estradiol and progesterone modulate neurotransmitters, and how they impact brain health and cognition in perimenopause and menopause. This is truly a conversation you will not want to miss. Be sure to stay tuned for my second discussion with the insightful Dr. Felice Gersh. IN THIS EPISODE, YOU WILL LEARN: The value of progesterone beyond simply protecting the uterine lining What progesterone does that synthetic progestins cannot do How the risks and side effects of synthetic progestins unfairly tarnished the reputation of progesterone How progesterone supports nitric oxide signaling and vascular health The essential role progesterone plays in stabilizing the nervous system The role of progesterone in supporting mitochondrial function, musculoskeletal health, and connective tissue repair Symptoms that could appear or worsen when progesterone levels are low Dr. Gersh reframes ovarian aging as a core marker of aging in women  Factors that could impair ovarian function and hormone production Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Felice Gersh On her website: Integrative Medical Group of Irvine Instagram All of Dr. Gersh’s books are available on Amazon.

Transcribed - Published: 21 March 2026

Welcome to this week’s Midlife Minute episode. Today’s podcast kicks off a three-part series exploring the fiber gap in midlife. Although fiber is neither glamorous nor trendy, and not particularly exciting, it is one of the most powerful tools we have to support our metabolism, gut health, and hormones in midlife. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: Fiber is critical for women in perimenopause and menopause! How the insufficient fiber intake of the average American may be increasing the prevalence of colorectal cancer in younger individuals How fiber affects gut motility, blood sugar stability, cholesterol levels, and satiety Why fiber is not only for digestion but also for metabolic and hormonal regulation How fiber supports our gut health How fiber can help in reducing factors associated with increased autoimmune risk Some common misconceptions about fiber debunked Practical tips for improving your fiber consumption Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Download Cynthia’s 10 Fiber-Rich Carbohydrates that Support Midlife Metabolism List HERE. Research Links Relation of dietary fat and fiber to elevation of C-reactive protein Cholesterol-lowering effects of dietary fiber: a meta-analysis The effect of fiber on satiety and food intake: a systematic review The emergence of the metabolic syndrome with menopause The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease Dietary fiber and body weight

Transcribed - Published: 19 March 2026

I am thrilled to reconnect with Dr. Izabella Wentz today. She is a pioneering clinical pharmacist and best-selling author, with a passion for identifying the root causes of complex health conditions. She has consulted on 1000s of difficult cases, and her upcoming book is called IBS: Finding and Treating the Root Cause of Irritable Bowel Syndrome. In today’s conversation, we explore relevant statistics, dietary triggers, and specific labs that can be helpful when navigating an IBS diagnosis. We highlight red flags, examine the impact of fiber, the intricate connection between short-chain fatty acids and thyroid health, and how stress, trauma, and the nervous system affect gut health. Dr. Wentz also offers some practical strategies and answers a series of rapid-fire questions. Dr. Wentz’s latest book offers a fascinating exploration of IBS, guiding readers through diagnosis and treatment options, and empowering them to advocate for themselves. IN THIS EPISODE, YOU WILL LEARN: How IBS is often given as a diagnosis without any lab testing or further investigation Some of the lesser-known dietary IBS triggers, and how IBS-type symptoms can sometimes signal an entirely different underlying condition How digestive dysfunction can drive IBS symptoms Why fiber is essential, and how to increase your fiber intake slowly to avoid any digestive distress How stress can exacerbate IBS symptoms Constipation as a symptom of IBS Why most women tend to have a leaky gut Challenges of restrictive diets and the need for a balanced approach to gut health First steps to take when treating IBS Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com. Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Izabella Wentz On Instagram Dr. Wentz’s latest book, Finding and Treating the Root Cause of Irritable Bowel Syndrome, will be available for purchase on Amazon and in any reputable bookstore on March 17th.

Transcribed - Published: 18 March 2026

Today, I have the honor of connecting with Temple Stewart! She is a registered dietician specializing in low-carb dieting for women’s weight loss.  I have spoken on the stage with Temple several times over the last year, and she is delightful! In this episode, she shares her background, and we dive into how she was able to reverse her PCOS and Hashimoto’s by adopting a low-carbohydrate ketogenic diet. We discuss food psychology, woke nutrition, whether “if it fits your macros” is a good philosophy, issues with the traditional allopathic nutrition model, and challenges in nutrition research. We also get into plateau busters and share five ways to measure success other than the scale.  IN THIS EPISODE YOU WILL LEARN: How Temple transformed her life by using nutrition as medicine. Which foods tend to provoke inflammation in the thyroid gland in women? How people’s relationships with food play into the work Temple does. Temple shares her thoughts on woke nutrition. Temple dives into some of the big issues with the allopathic nutrition model. I share some interesting statistics related to American health. Creating consumer awareness will hopefully lead consumers to demand more for their health in the food supply and health care. Why is it so challenging to do nutritional research? Temple offers a starting point for addressing weight-loss resistance. What carbohydrate reduction or restriction does for us metabolically. The benefits of following a carnivore diet. Why do we need to read food labels and become aware of where sugar may sneak into our diets? Temple shares her favorite ways to break plateaus. Five ways to measure success other than the scale.   Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Temple Stewart On ⁠Instagram⁠, ⁠TikTok⁠, ⁠Twitter⁠, and ⁠Spotify⁠ (@the.ketogenic.nutritionist) ⁠The Ketogenic Nutritionist Podcast⁠ Books mentioned: ⁠Metabolical⁠, by Robert Lustig

Transcribed - Published: 16 March 2026

Today, I’m thrilled to reconnect with my friend and colleague, Dr. Carrie Jones. She is a naturopathic physician and hormone expert with over 20 years of clinical experience in women's health and endocrinology. In our discussion, we unpack the limitations of traditional hormone testing and explore the benefits of saliva, urine, and blood testing for gaining a more accurate picture of hormone activity. We explore the critical importance of lab timing and how the DUTCH test evaluates estrogen, metabolism, and cortisol rhythms. We also examine how liver detoxification affects the active form of thyroid hormone, T3, across phases one through three, highlight signs and symptoms that indicate an imbalanced gut microbiome, and wrap things up with some rapid-fire questions about the things you’ve probably wanted to ask. Stay tuned for another invaluable, humorous, and fun conversation with Dr. Carrie Jones. IN THIS EPISODE, YOU WILL LEARN: How blood tests give only a snapshot in time without clarifying hormone pulses or tissue utilization How testing hormones at the wrong time can temporarily skew test results The optimal timing for testing in women with regular cycles and those in perimenopause What the DUTCH test measures How regular vs. irregular cycles affect which hormones should be tested Why the way that estrogen is metabolized matters more than the estrogen itself  How phases one, two, and three of liver detoxification influence estrogen, cortisol, and thyroid hormone activity Why free T3 is critical for eliminating cortisol What gut symptoms reveal about hormone elimination Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Carrie Jones On Instagram Estrogen Detox Made Easy Hello Hormones with Dr. Carrie Jones - Podcast

Transcribed - Published: 14 March 2026

Welcome to this week’s Midlife Minute. Many women have been asking why they wake up at 2, 3, or 4 am every night. So today, I'm breaking down 10 common reasons this happens. I’ve also included some research links in the show notes for those who want to learn more. Stay tuned as I unpack the key factors that disrupt women’s sleep in midlife. IN THIS EPISODE, YOU WILL LEARN: Cortisol spikes and sleep disruptions Why caloric restriction and repeated fasting could stress the body and lead to an overactive sympathetic nervous system The link between declining progesterone and nighttime awakenings How chronic under-eating or over-exercising can disrupt sleep, recovery, and metabolic health Why estradiol fluctuations make it harder to stay asleep  Alcohol and late-night sugar fragment sleep Hormonal changes during perimenopause/menopause and increased sleep apnea risk How inflammation, leaky gut, and disrupted neurotransmitter production contribute to early awakenings Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Research Links Progesterone for treatment of symptomatic menopausal women Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women [EMPLOYMENT OF THE ELDERLY PEOPLE IN THE EUROPEAN UNION AND UKRAINE: REALITIES, PROBLEMS AND PROSPECTS] Obesity and its implications on oncological urological surgery Metastatic phenotype is regulated by estrogen in thyroid cells Soy protein isolate increases urinary estrogens and the ratio of 2:16alpha-hydroxyestrone in men at high risk of prostate cancer NMR at pressures up to 90 GPa

Transcribed - Published: 12 March 2026

Today, I am thrilled to connect with Dr. Zelana Montminy, who holds a doctorate in clinical psychology. Dr. Montminy developed her career speaking for and advising Fortune 500 companies and academic institutions. She regularly appears on Good Morning America, The Today Show, and Access Hollywood.  In our conversation, we unpack the concept of novelty bias, exploring how it shapes our neuroanatomy and compromises our conscientiousness. We debunk the myths of multitasking and task switching, and dive into generational shifts and our disconnection from ourselves and the world around us. We also highlight the vital role of the gut-brain connection, share practical social tools such as the Pomodoro Technique, and examine the transformative power of curiosity and awe.  This discussion with Dr. Zelana Montminy is an exciting and forward-thinking exploration of how our brains and bodies are programmed for distraction. Her book, Finding Focus, also offers a compelling narrative to help us get back on track. IN THIS EPISODE, YOU WILL LEARN: What is novelty bias?  How technology impacts our mental health and ability to empathize in the long term  Why are we seeing a loss of conscientiousness in the younger generations, and why do older generations tend to feel and process things more intensely? How constant exposure to technology affects the ability of the brain to process information  Generational differences in information processing The detrimental effects of multitasking on productivity and focusing ability, and the benefits of single-tasking and staying in the present moment How being in a constant state of fight or flight dysregulates the nervous system  The importance of nutrition, sleep, and hydration for mental health Tools and strategies to boost your ability to focus  The value of curiosity for problem-solving, resilience, and health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Zelana Montminy On her website Instagram Finding Focus: Own Your Attention in the Age of Distraction is available on her Website and on Amazon.

Transcribed - Published: 11 March 2026