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Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 600 “Breaking the ‘Limbic Lock’”– Why Your Brain Stalls in Healing and How to Fix It with Dr. Eboni Cornish |Menopause, Perimenopause, Brain Health

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Cynthia Thurlow

Science, Life Sciences, Health & Fitness, Nutrition, Alternative Health

4.71.2K Ratings

🗓️ 30 May 2026

⏱️ 60 minutes

🧾️ Download transcript

Summary

I’m delighted to connect with Dr. Eboni Cornish today. She is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society, specializing in complex chronic illness with expertise in brain health, Lyme disease, autoimmune conditions, mold exposure, gut dysfunction, and women’s midlife health. In our conversation, we explore how perimenopause and menopause affect the brain, as well as the roles of genetics and epigenetics. Dr. Cornish explains limbic lock, SPECT imaging, the impact of tick-borne illnesses, and co-infections, and how brain health issues can influence mental health. We also dive into the role of mold in testing, the gut-brain-immune-hormone axis, vagal tone, the estrobolome, leptin, the MTHFR mutation, and how Dr. Cornish prefers to have it tested and treated in her patients. Stay tuned for an insightful and wide-ranging conversation on brain health and women’s midlife wellness. IN THIS EPISODE, YOU WILL LEARN: Why women may experience brain fog, forgetfulness, and cognitive slowing as estrogen declines How declining estrogen could make the brain more vulnerable to toxins, infections, and leaky brain How disrupted sleep, poor nutrition, and lack of oxygen (from issues like sleep apnea) can negatively affect cognition and brain health The value of continuing to learn and staying socially connected to support your cognitive health as you age How genetics can help to identify women who may be at higher risk for cognitive decline later in life. What limbic lock means How toxin overload, mold, Lyme disease, and co-infections, and unresolved stress can create a state of limbic lock  How SPECT imaging helps to explain why some people fail to improve despite multiple treatments The benefits of progesterone for supporting relaxation and improving sleep during perimenopause How declining estrogen and gut dysbiosis during perimenopause can affect the gut-brain axis Bio: Dr. Eboni Cornish Dr. Eboni Cornish is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society. She specializes in complex chronic illness, with expertise in brain health, Lyme disease, autoimmune conditions, mold toxicity, gut dysfunction, and women’s midlife health. Known for her NeuroLongevity framework, Dr. Cornish takes a root-cause, brain-first approach to helping patients optimize cognitive resilience, hormone balance, and long-term wellness. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Eboni Cornish Amen Clinics On her website Instagram

Transcript

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0:00.0

Welcome to Everyday Wellness Podcast.

0:03.6

I'm your host, nurse practitioner, Cynthia Thurlow.

0:07.4

This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.

0:13.8

My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and impact over a million lives.

0:29.1

Today I had the honor of connecting with Dr. Ebony Cornish.

0:33.4

She's the Associate Medical Director of AIMN clinics and president of the International Lyme and Associated Diseases Society, and she specializes in complex chronic illness with an expertise in brain health, Lyme, autoimmune, mold, gut dysfunction, and women's midlife health.

0:50.4

Today we spoke about how perimenopause and menopause affect the brain, specifically limbic shifts,

0:56.1

cognitive changes, emotional dysregulation and sleep, risk factors for poor cognitive health,

1:02.0

as well as the role of epigenetics and genetics. What limbic lock is? The role of spec imaging,

1:09.5

revealing how hormones, toxins, inflammation, and infections alter

1:13.0

brain profusion, the impact of tick-borne illnesses as well as co-infections.

1:18.4

How brain health issues can change our mental health, the role of mold and testing, the gut-brain

1:25.1

hormone axis, vagal tone, the oestrobillome and leptin, and last

1:30.0

but not least, the MTHFR mutation, how it shows up and how she likes to have this tested and

1:36.8

treated with her patients. Dr. Cornish is absolutely delightful. Her down-to-earth nature

1:43.7

just makes me so interested in the research that she's

1:48.3

doing and how she approaches patient care. Hopefully this will be a conversation you will listen to

1:54.1

more than once. Dr. Cornish, such a pleasure to finally meet you virtually in real life. Welcome to everyday wellness.

2:06.1

Thank you so much for the invitation. I feel like we're already besties, you know, all the school people.

2:11.0

About living in Northern Virginia and all the, you know, all the idiosyncrasies that go right along with that.

2:16.6

I'd love to initiate the conversation today talking about how perimenopause and

2:22.1

menopause are impacting our brains because I think for a lot of women, they're shocked.

...

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