Ep. 584 "Slowing the Engine” – How GLP-1s Alter Your Gut Motility & Microbiome | Menopause, Perimenopause & Gut Health

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Cynthia Thurlow

Science, Life Sciences, Health & Fitness, Nutrition, Alternative Health

4.7 • 1.2K Ratings

🗓️ 23 April 2026

⏱️ 21 minutes

🔗️ Recording | iTunes | RSS

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Summary

Welcome to today’s Midlife Minute. In this episode, I answer listeners’ questions about GLP-1 medications and midlife weight changes. I explore how hormonal shifts, insulin sensitivity, muscle mass, and the gut microbiome influence the effectiveness of these drugs, and explain why they should be regarded as part of a broader metabolic and lifestyle framework. IN THIS EPISODE, YOU WILL LEARN: Why GLP-1 medications don’t necessarily fix the root cause of midlife weight gain How declining estrogen can disrupt your appetite and satiety hormones The value of checking your fasting insulin to understand your insulin sensitivity level How inadequate protein can cause cravings for processed carbohydrates and fats Why preserving muscle mass is critical to prevent sarcopenic obesity How GLP-1 medications affect digestion and gut motility The clinical factors that are considered when prescribing GLP-1 medications Some simple daily habits to support your metabolic and microbiome health when using GLP-1 medications Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Transcript

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0:00.0	Welcome to Everyday Wellness Podcast.
0:04.0	I'm your host, Nurse Practitioner Cynthia Thurlow.
0:07.0	This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.
0:13.0	My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and impact over a million lives.
0:29.0	This is the start of a new Thursday series called The Midlife Minute that is really designed to address listeners questions in a little bit
0:40.0	longer length of time and or deeper dive into topics. Ideally, we're going to keep these
0:46.2	podcasts under 20 minutes. Occasionally, we may go over to 30, but I'm trying to reinforce
0:52.5	some key concepts and ensure that I'm addressing listeners' questions
0:58.5	in a way that's really helpful.
1:00.5	So the questions that I will be addressing topics are going to be items that I'm being asked
1:05.2	over and over and over again.
1:06.5	I hope you enjoy this series.
1:08.1	Please share with your friends.
1:09.7	And as you know know you can always send
1:11.7	your questions to support at cynthia thurlow.com i appreciate each and every listener
1:17.5	latest episode of the midlife minute lots of questions around glp1 so we're going to unpack
1:25.1	these i have quite a few questions i'm going to try to get through a
1:28.9	compilation of them during the course of this short but sweet midlife minute. Question number one,
1:37.6	I got this multiple times. Are GLP1 medications fixing the root cause of midlife weight gain or
1:43.4	just suppressing our appetite.
1:46.1	Number one, we know that we start losing some degree of insulin sensitivity in perimenopause
1:52.6	with alterations in estradiol, which is our predominant form of estrogen, our bodies make
	...

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