Science Weekly

Ian Sample is joined by James Kinross, colorectal surgeon and author of the book Dark Matter: The New Science of the Microbiome, to answer all your questions about gut health. In episode one, James explains how the gut microbiome gets set up, how it impacts our early development, and the effect antibiotics can have on our microbes. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 27 May 2025

Doctors in the US have become the first to treat a baby with a customised gene-editing therapy after diagnosing the child with a severe genetic disorder that kills about half of those affected in early infancy. Ian Sample explains to Madeleine Finlay how this new therapy works and how it paves the way for even more complex gene editing techniques. David Liu, a professor at the Broad Institute of MIT and Harvard and the inventor of these therapies, also describes the barriers that could prevent them reaching patients, and how he thinks they can be overcome. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 22 May 2025

In March 2021, the Toronto-based reporter Leyland Cecco heard about a memo sent by New Brunswick health officials that warned about a possible unknown neurological syndrome thought to be affecting about 40 people. Since then the story has taken many twists and turns, most recently with a peer-reviewed study that concludes there is no mystery illness after all. Cecco tells Madeleine Finlay about the devastating symptoms that patients experienced, and why the research is unlikely to resolve the conflict over what has been causing them. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 20 May 2025

Geoengineering, the controversial set of techniques that aim to deliberately alter the Earth’s climate system, may be inching a step closer to reality with the announcement that UK scientists will be conducting real-world experiments in the coming years. To understand what’s happening, Ian Sample is joined by the Guardian environment editor Damian Carrington. Damian explains what the experiments will entail and why scientists are so divided on whether pursuing this research is a good idea. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 15 May 2025

For a long time the appendix was considered disposable. After all, millions of people have theirs removed each year and go on to live healthy lives. But as Heather F Smith, a professor of anatomy at Midwestern University tells Ian Sample, researchers are increasingly understanding what this small worm-shaped organ may be bringing to the table in terms of our health. Smith explains how the appendix is linked to both our immune system development and gut health, and why she thinks an increasing interest in the microbiome may bring it to greater prominence. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 13 May 2025

Science correspondent Hannah Devlin joins Ian Sample to discuss three intriguing science stories from the week, from a global study that puts the UK third from bottom when it comes to flourishing, to a man who intentionally suffered more than 200 snake bites in the quest to find a universal antivenom and a breakthrough in the quest to understand the contents of the charred Herculaneum scrolls buried when Mount Vesuvius erupted. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 8 May 2025

Direct to consumer tests that claim to tell us our biological – as opposed to chronological – age are getting a lot of attention, but what can they really tell us about our health? Science editor Ian Sample talks to Dr Brian H Chen, an epidemiologist at the California Pacific Medical Center Research Institute, who has conducted research into a variety of these tests called epigenetic clocks. He explains what exactly they are measuring and whether, once we have the results, there are any evidence-based strategies we can adopt to lower our biological age. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 6 May 2025

Authorities are still trying to understand what triggered the massive power outage that left the majority of the Iberian Peninsula without electricity on Monday. To understand what might have been at play, and whether there’s any truth to claims that renewable energy sources were to blame, Ian Sample hears from Guardian energy correspondent Jillian Ambrose. And Guardian European community affairs correspondent Ashifa Kassam explains what it was like to experience the blackout and how people reacted. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 1 May 2025

Just Stop Oil, the climate activism group behind motorway blockades, petrol station disruption and tomato soup attacks on major artworks, has disbanded after staging a final action in London this weekend. To find out why the group has decided to hang up the famous orange high-vis, Madeleine Finlay hears from our environment correspondent Damien Gayle who has been covering Just Stop Oil since its inception. He explains how policy wins and policing crackdowns combined to bring the movement to a close, and what the future of climate activism could look like in its wake. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 29 April 2025

Madeleine Finlay and Ian Sample discuss three intriguing science stories from the week. From a hint at alien life on a distant planet to a clue in the search for answers over why colon cancer rates are rising in the under 50s, and news from scientists who claim to have found a colour no one has seen before. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 24 April 2025

The American biotech company Colossal Biosciences recently made headlines around the world with claims it had resurrected the dire wolf, an animal that went extinct at the end of the last ice age. But does what the company has done amount to ‘de-extinction’ or should we instead think of these pups as genetically modified versions of the grey wolves that exist today? Science correspondent Nicola Davis tells Madeleine Finlay about the process that created these wolves, how other companies are joining the effort to use genetic modification in conservation, and why some experts have serious ethical questions about bringing back species whose habitats no longer exist. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 22 April 2025

As a measles outbreak expands across the US, comments by health secretary Robert F Kennedy Jr have come under scrutiny. Kennedy has said that the best way to prevent measles is to get vaccinated – but he has also caused alarm among paediatricians, vaccine experts and lawmakers by promoting vitamin A and nutrition as treatments for measles and questioning the safety testing of the MMR vaccine. He also recently announced a US-led scientific effort to establish the cause of what he terms the ‘autism epidemic’, with some experts concerned that this study will support the widely discredited association between autism and vaccines. US health reporter Jessica Glenza tells Ian Sample, the Guardian’s science editor, how these mixed messages are already impacting scientific research.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 17 April 2025

Robin McKie reflects on his 40 years as science editor for the Observer and tells Madeleine Finlay about the game-changing discoveries and scientific controversies that he’s reported on during that time. He describes how the discovery of the structure of DNA revolutionised science, what he learned about misinformation from the HIV/AIDS pandemic and why cold fusion and the millennium bug failed to live up to their hype.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 15 April 2025

Switzerland is leading the world in purifying its water of micropollutants, a concoction of chemicals often found in bodies of water that look crystal clear. They include common medicines like antidepressants and antihistamines, but have unknown and potentially damaging consequences for human and ecosystem health. In the second of a two-part series, Phoebe Weston travels to Geneva to find out how the country has transformed its rivers from sewage-filled health hazards to pristine swimming spots. She tells Madeleine Finlay how a public health disaster in the 1960s spurred the government to act, and what the UK could learn from the Swiss about taking care of a precious national asset.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 10 April 2025

The UK is known for its national parks: areas of outstanding natural beauty with rolling hills and crystal-clear streams and lakes. But research has shown that England’s most protected rivers are full of pharmaceuticals. In episode one of a two-part series, biodiversity reporter Phoebe Weston tells Madeleine Finlay about the problem of chemical pollution in our waterways, and how it could be contributing to what the World Health Organization has described as ‘the silent pandemic’ – antimicrobial resistance.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 8 April 2025

Invertebrates don’t get the attention lavished on cute pets or apex predators, but these unsung heroes are some of the most impressive and resilient creatures on the planet. So when the Guardian opened its poll to find the world’s finest invertebrate, readers got in touch in their droves. A dazzling array of nominations have flown in for insects, arachnids, snails, crustaceans, corals and many more obscure creatures. Patrick Barkham tells Madeleine Finlay why these tiny creatures deserve more recognition, and three readers, Sandy, Nina and Russell, make the case for their favourites.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 3 April 2025

While other diet fads come and go, the ultra low carbohydrate Keto diet seems to endure. But as scientists begin to understand how the diet works, more is also being discovered about its risks. To find out more, Madeleine Finlay speaks to Javier Gonzalez, professor in the department of health at the University of Bath, with a special interest in personal nutrition. He explains how the diet works, what it could be doing to our bodies and what could really be behind the weight loss people experience while on it. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 1 April 2025

The genetic testing firm 23andMe has filed for bankruptcy, another twist in the story of a company that promised a pioneering approach to precision health. Now users are scrambling to delete their personal data, with the future ownership of the firm uncertain. To understand the highs and lows of 23andMe’s journey, Madeleine Finlay hears from the Guardian US tech reporter and editor Johana Bhuiyan, and from Timothy Caulfield, a professor of law at the University of Alberta, who has a special interest in health and biotechnology. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 27 March 2025

It’s a mystery that has long puzzled researchers. Why can’t we remember our early childhood experiences? Freud called the phenomenon infantile amnesia, and for many years scientists have wondered whether it’s a result of failure to create memories or just a failure to retrieve them. Now new research appears to point to an answer. To find out more, Ian Sample talks to Nick Turk-Browne, a professor of psychology at Yale University.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 25 March 2025

Dark energy, the mysterious force powering the expansion of the universe, appears to be weakening over time, according to a major cosmological survey that has thrown the laws of modern physics into doubt. Ian Sample tells Madeleine Finlay how this new finding could shed light on the ultimate fate of the cosmos, and Saul Perlmutter, who won a Nobel prize for his work proving the universe is expanding, describes how the new development could upend assumptions about how this mysterious force operates. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 20 March 2025

Before billionaires dreamed of setting up communities on Mars, the ocean was seen as the next frontier in human habitation. Reviving this dream is Deep, a project backed by an anonymous millionaire to the tune of more than £100m that aims to establish a ‘permanent human presence’ under the sea from 2027. Guardian Seascape editor Lisa Bachelor visited the project just outside Chepstow on the Welsh border, and tells Madeleine Finlay what scientists hope to learn about the ocean by spending extended periods living underwater. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 18 March 2025

Before billionaires dreamed of setting up communities on Mars, the ocean was seen as the next frontier in human habitation. Reviving this dream is Deep, a project backed by an anonymous millionaire to the tune of more than £100m that aims to establish a ‘permanent human presence’ under the sea from 2027. Guardian Seascape editor Lisa Bachelor visited the project just outside Chepstow on the Welsh border, and tells Madeleine Finlay what scientists hope to learn about the ocean by spending extended periods living underwater. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 18 March 2025

Many of us believe that cognitive decline is an inevitable part of ageing, but a new study looking at how our skills change with age challenges that idea. Ian Sample talks to Ludger Wößmann, a professor of economics at the University of Munich and one of the study’s authors, to find out how the team delved into the data to come to their conclusions, and what they discovered about how we can all maintain our faculties for as long as possible. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 13 March 2025

The Mars we know now is arid and dusty, with punishing radiation levels. But, as science correspondent Nicola Davis tells Madeleine Finlay, two new studies add weight to the idea that billions of years ago the red planet was a much wetter place. Nicola explains why researchers now think it was once home to sandy beaches, what a study looking into the type of rust on the planet has revealed about its damp past, and what all this might tell us about the former habitability of Mars. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 11 March 2025

Madeleine Finlay and Ian Sample discuss three intriguing science stories from the week. From two private moon landings to the controversy over Elon Musk’s continued membership of the Royal Society, and a new study making a link between men’s health and their sperm quality. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 6 March 2025

Beavers were once abundant in the UK, but hunting them for their fur, meat and scent oil drove them to extinction. Now they’re back, with the news that the release of beavers into English waterways is to be allowed for the first time in centuries. To understand why this is seen as a huge win for the environment, Madeleine Finlay hears from the Guardian’s environment reporter Helena Horton.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 4 March 2025

When the palaeontologists of the future search for clues to understand how we lived, what might they find? Two scientists exploring this question have suggested that ‘technofossils’ will be our lasting imprint on the Earth. To find out exactly what these are and what they could reveal about our lives, Madeleine Finlay hears from the Guardian’s environment editor, Damian Carrington, and from Sarah Gabbott, a professor of palaeontology at the University of Leicester and one of the scientists behind the new book Discarded: How Technofossils Will Be Our Ultimate Legacy. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 27 February 2025

In his first month in office the US president has thrown science in the US into chaos, delaying projects and casting the future of research funding and jobs into doubt. To understand everything that has happened in the month since he took office and what its impact could be, Madeleine Finlay hears from science editor Ian Sample and Prof Harold Varmus, a Nobel prize winner and former director of the National Institutes of Health under Bill Clinton. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 25 February 2025

Science editor Ian Sample joins co-host Madeleine Finlay to discuss some of the most intriguing science stories of the week. From a concerning rise in hospital diagnoses of constipation in children, to research suggesting that the environment is far more important for ageing and longevity than our genes, and how squeaks from genetically engineered mice are providing insight into how human language may have emerged. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 20 February 2025

The Scottish first minister, John Swinney, was recently forced to deny plans to ban cats after a report from independent experts said the species was a threat to Scotland’s wildlife. In the UK, it is estimated that cats kill or bring home 57 million mammals and 27 million birds every year. Ian Sample hears from cat-owner Madeleine Finlay and the ecologist Prof Robbie McDonald about the best ways to reduce our feline companions’ impact on wildlife without affecting welfare. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 18 February 2025

Recently, a group of world-leading scientists called for a halt on research to create ‘mirror life’ microbes amid concerns that the synthetic organisms would present an ‘unprecedented risk’ to life on Earth. Ian Sample tells Madeleine Finlay about why this work initially seemed exciting for scientists and what the risks of it continuing could be. And Kate Adamala, assistant professor of genetics, cell biology and development at the University of Minnesota, describes what made her change her mind about pursuing her own research on mirror cells. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 13 February 2025

In a case of life imitating art, a 100-metre-wide asteroid has triggered global planetary defence procedures for the first time, after telescope observations revealed it had a chance of colliding with Earth in 2032. To find out what happens now and how worried we should be, Ian Sample hears from Richard Binzel, a professor of planetary sciences at MIT and inventor of the Torino scale, which is used to categorise the threat posed by objects such as asteroids and comets. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 11 February 2025

From the shockwaves caused by DeepSeek’s launch, to fears of a new AI arms race, and the continued questions over the technology’s energy use, AI continues to throw up new challenges. As world leaders gather for the Paris AI summit, the Guardian’s global technology editor, Dan Milmo, joins Madeleine Finlay to discuss what will be top of the agenda. And young people attending the Alan Turing Institute’s Children’s AI summit explain what their hopes and fears for the technology are. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 6 February 2025

Senators are scheduled to vote today on whether to advance Robert F Kennedy Jr’s nomination as Secretary of State for Health and Human Services. RFK Jr is known for his vaccine skepticism and Make America Healthy Again slogan, which has won him support from everyone from wellness fans and ‘crunchy moms’ to traditional Republicans. US health reporter Jessica Glenza tells Ian Sample about how he fared at last week’s confirmation hearings, and what he might do if he takes a seat in Trump’s cabinet. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 4 February 2025

In the second episode of our listener questions special, Ian Sample tells Madeleine Finlay what he has uncovered about who the exercise guidelines were created for and whether they apply to all of us, which exercises are best for keeping us strong, whether we should be eating particular foods when we exercise, and how much protein we need to consume if we’re packing in the hours at the gym. With contributions from Jason Gill, professor of cardiometabolic health at the University of Glasgow; Benjamin Wall, professor of nutritional physiology at the University of Exeter; Clyde Williams, emeritus professor of sports science at Loughborough University; Victoria Taylor, head of clinical support at the British Heart Foundation and I-Min Lee, professor of medicine at Harvard Medical School. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 30 January 2025

We asked for your questions on getting healthy in 2025 and you delivered. In the first episode of our listener questions special, Madeleine Finlay tells Ian Sample what she has uncovered about the scientifically proven ways to cut down on sugar, the truth behind the panic over seed oils, and why it is that some of us seem to have bullet proof immune systems, while others succumb to every bug they encounter. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 28 January 2025

Ian Sample speaks to Keon West, a professor of social psychology at the University of London, whose new book, The Science of Racism, explores what science can reveal about racism, the inventive methods scientists have used to study it and the scientifically proven ways of tackling racism and discrimination. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 23 January 2025

A podcast promoting claims that non-verbal autistic children can read minds briefly knocked Joe Rogan off the top of the charts this month, which made the Science Weekly team wonder, how has science attempted to prove or disprove the existence of mind reading? To find out, Ian Sample speaks to Chris French, emeritus professor of psychology at Goldsmiths University. They discuss how scientists have tested this phenomenon, what else could be behind the apparent ability of some people to read minds, and why the idea is still so popular. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 21 January 2025

Last year was full of unexpected science news, from a new strain of Mpox emerging in the DRC, to artificial intelligence dominating the Nobel prizes and two astronauts getting ‘stuck’ in space. So what will this year bring? Ian Sample and science correspondent Hannah Devlin discuss the big stories likely to hit the headlines and share their predictions for 2025. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 16 January 2025

As wildfires continue to cause devastation in Los Angeles, Madeleine Finlay speaks to Albert van Dijk, professor of water science and management at the Australian National University, about how rising temperatures are causing rapid swings in extreme weather. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 14 January 2025

The Oxford English Dictionary announced its word of the year at the end of 2024: brain rot. The term relates to the supposedly negative effects of consuming social media content, but it struck a chord more widely with many of us who feel we just don’t have the mental capacity we once did. Gloria Mark, a professor of informatics at the University of California, Irvine, has been studying our waning attention spans for 20 years. She tells Madeleine Finlay why she believes our powers of concentration are not beyond rescue, and reveals her top tips for finding focus. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 9 January 2025

Scientists are increasingly finding that behaviours once seen as depraved often have a direct physical cause. To find out more, Ian Sample hears from Guy Leschziner, a consultant neurologist and sleep physician at Guy’s and St Thomas’ hospital in London. His new book, Seven Deadly Sins: The Biology of Being Human, looks at the neurological basis of behaviours often dismissed as evidence of bad character or lack of willpower. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 7 January 2025

You might have noticed that everyone has recently become a bit obsessed with blood sugar, or glucose. Wellness firms such as Zoe in the UK – as well as Nutrisense, Levels and Signos – claim to offer insights into how our bodies process food based on monitoring our blood glucose, among other things. But many researchers have begun to question the science behind this. In this episode from July, Ian Sample talks to the philosopher Julian Baggini, the University of Oxford academic dietician Dr Nicola Guess, and Zoe’s chief scientist the King’s College London nutrition expert Prof Sarah Berry to find out what we know about blood glucose levels and our health, and whether the science is nailed down on personalised nutrition. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 2 January 2025

For the regular drinker, the studies that say a daily tipple is better for a longer life than avoiding alcohol completely are a source of great comfort. But a new analysis challenges that thinking and says it was based on flawed research that compares drinkers with people who are sick and sober. In this episode from August, Madeleine Finlay hears from the study’s lead author, Tim Stockwell, a scientist at the Canadian Institute for Substance Use Research at the University of Victoria, to find out why scientists (including him) were so convinced, and what the actual risks of alcohol are. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 31 December 2024

In this episode from July, Ian Sample talks to Josh Davis, a science writer at the Natural History Museum in London and author of the book A Little Gay Natural History. A study published in June 2024 suggested that, although animal scientists widely observe same-sex sexual behaviour in primates and other mammals, they seldom publish about it. Josh considers why this might be and describes some of his favourite examples of sexual diversity from the animal kingdom.. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 26 December 2024

In this episode from September, Madeleine Finlay speaks to Dr Saul Newman, an interdisciplinary researcher at University College London and the University of Oxford, who has recently won an Ig Nobel prize – given to scientific research that ‘first makes people laugh, and then makes them think’ – for his work showing that many claims of people living extraordinarily long lives come from places with short lifespans, no birth certificates, and where clerical errors and pension fraud abound. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 24 December 2024

Dr Chris van Tulleken has been at the forefront of the campaign to change our food system and better regulate the sale of ultra-processed foods (UPF). This year he will be giving the Royal Institution Christmas lectures, Britain’s most prestigious public science lectures, in which he’ll be investigating how food has fundamentally shaped human evolution, the importance of our microbiome – as the extra ‘organ’ we didn’t know we had – and how we can all eat better in future, for the sake of our own health and the health of the planet. Nicola Davis sat down with Van Tulleken to discuss the lectures, the challenge of understanding the impact of UPFs on our health, and his top tip for Christmas dinner. Madeleine Finlay hears from them both in this Christmas special edition of Science Weekly. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 19 December 2024

For the past 10 years cosmologists have been left scratching their heads over why two methods for measuring the universe’s rate of expansion provide totally different results. There are two possible solutions to the puzzle, known as the Hubble tension: either something is wrong with the measurements or something is wrong with our model of the universe. It was hoped that observations from the James Webb space telescope might shed some light on the problem, but instead results published last week have continued to muddy the waters. To understand why the expansion rate of the universe remains a mystery, and what might be needed to finally pin it down, Madeleine Finlay speaks to Catherine Heymans, the astronomer royal for Scotland and a professor of astrophysics at the University of Edinburgh. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 17 December 2024

On Monday Google unveiled its Willow quantum computing chip. The new chip takes just five minutes to complete tasks that would take 10 septillion years for some of the world’s fastest conventional computers to complete. But despite its impressive power, it’s not clear the chip has any practical applications. So does it bring quantum computing any closer? To find out Ian Sample speaks to Winfried Hensinger, professor of quantum technologies at the University of Sussex. Because of industrial action taking place by members of the National Union of Journalists at the Guardian and Observer this week, you may notice some disruption to the availability of new episodes in your Guardian podcast feeds in the coming days. All the work on this episode was done before the strike action began. For more information please head to theguardian.com. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 12 December 2024

Madeleine Finlay speaks to Sophie Scott, a professor of cognitive neuroscience at University College London, to dig into the science of laughter. Sophie explains what exactly laughter is, the many different purposes it serves for humans and animals, and how prioritising it could make us all feel a little better. Help support our independent journalism at theguardian.com/sciencepod

Transcribed - Published: 10 December 2024