Welcome to Unbiased Science, where we bring scientific method to the madness.

I am your host, Dr. Sarah Scheinman.

My co-host, Dr. Jess Steyer, is actually currently giving a guest lecture at Brown University.

So we're very proud of her, but that's why I am flying solo today.

But I am very, very excited to be joined today by Dr.

Roberto Carrillo to discuss a topic that's very, very exciting and interesting to me in

particular, which is, which is lupus. So I'm going to read a little bit of a bio here, and then we are going to dive into our

conversation. I've got lots and lots of questions. So Dr. Roberto Carrickio is the chair and

chief of the Division of Rheumatology at UMass Chan Medical School and the vice chair of the Lupus Clinical Investigators Network

Clinical Research Program overseen by Lupus Therapeutics. He earned his MD and Rheumatology

training at the Catholic University of the Sacred Heart in Rome, with postdoctoral fellowships at the University of North Carolina

at Chapel Hill and the University of Pennsylvania, as well as additional internal medicine and

rheumatology training at Temple University, all while leading an NIH-funded Lupus Laboratory.

He previously directed the Temple Lupus program and founded the

UMass Lupus Center. His work has defined mechanisms linking cell death, hormones,

the microbiome, and infections to lupus pathogenesis and organ damage. He has published in leading

journals including immunity, nature, and JAMA, and continues to lead

translational lupus research and specializes specialized clinical programs at UMass Chan.

Roberto, welcome to the show. Thank you. Glad to be here. And thank you for the candid

introduction. Oh, absolutely. I mean, we, honestly, there is no one better, I think, to be here talking to us about lupus than you, sir. So, thanks for joining us.

Thank you.

I just as like a personal note. So when I, when I think of lupus, I sort of grew up watching this medical show called House MD. And, you know, it's a, it's a medical show about a diagnostician. I think he's like an infectious disease specialist. And him and his team start out, every time they have a case, they do this differential diagnosis, and they have this whiteboard where they write down all the possibilities.

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