What's next for CRISPR
Recode Daily
Recode
4.6 • 1.3K Ratings
🗓️ 25 February 2020
⏱️ 28 minutes
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| 0:00.0 | Inside each one of your cells there's a code. That code is your DNA and it plays a role in determining a lot about you like your height, the color |
| 0:16.7 | of your hair and how likely you are to get certain diseases. |
| 0:20.3 | So what if you could rewrite it? |
| 0:29.4 | That question has animated scientists for decades. But until recently, most of the methods they developed to edit DNA in living people were limited, messy, and expensive. |
| 0:38.0 | Then in 2012, scientists proposed a new technique that revolutionized gene editing. |
| 0:44.0 | It's called CRISPR, and turns out it had been hanging out in nature all along, in bacteria. |
| 0:52.0 | Certain species of bacteria have what amounts to a genetic scalpel that can be used to cut DNA. |
| 0:58.0 | Scientists found that they could harness that scalpel and use it to modify stretches of DNA in just about any living organism, quickly and cheaply. |
| 1:07.0 | Since CRISPR was developed, scientists have found loads of applications for it, from agriculture |
| 1:17.1 | to zoology. But the question we started out with, can we edit human DNA safely and ethically? That's been more difficult to answer. |
| 1:27.0 | We're now starting to see promising results in human trials that use CRISPR to treat genetic diseases. |
| 1:36.0 | But we've also just seen a Chinese scientist get sentenced to three years in prison |
| 1:42.0 | after he edited the DNA of twin girls. |
| 1:45.0 | So with all that in mind, how does a parent of this technology think about it now? |
| 1:51.0 | Jennifer Dowdna helped develop CRISPR back in 2012. She's a |
| 1:55.1 | biochemist at the University of Berkeley in California and she is in many ways |
| 1:59.6 | the public face of CRISPR. |
| 2:07.0 | Today on the show, my interview with Jennifer Doudna, her reflections on the impact of CRISPR, its past, and its future. |
| 2:12.0 | I'm Ariel Zimross. This is reset. Okay, so we're here with Jennifer Dowdna. |
| 2:26.0 | Jennifer, in many ways, you've become the voice of this technology. |
| 2:31.0 | So how do you cope with that? |
| 2:32.0 | Just for me personally, you know, it's definitely, it's been a process. |
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