Weight Regain After GLP1s & Why It's Expected | Solo

The Dr. Tyna Show

Dr. Tyna Moore

Alternative Health, Health & Fitness

4.9 • 1.7K Ratings

🗓️ 16 January 2026

⏱️ 64 minutes

🔗️ Recording | iTunes | RSS

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Summary

EP. 244: In today’s episode, I break down the new BMJ study on weight regain after stopping GLP-1 medications and explain why these headlines do not mean GLP-1s are ineffective. Truth is, most people don’t realize how medication for a chronic disease works. I unpack what the research actually shows about obesity as a disease, treating vs. curing obesity, weight regain, metabolism, and why this outcome is expected when treating ANY chronic condition. I also touch on why high-dose GLP-1 use without strength training, gut support, and sustainable lifestyle changes can create problems long term, and what a more thoughtful approach to metabolic health really looks like. → This Natural GLP-1 Stimulator Actually Works | Calocurb with Sarah Kennedy → Head to Calocurb.com/DRTYNA and use code DRTYNA for 10% off Topics Discussed: → Why does weight regain happen after stopping GLP-1s? → Are GLP-1 medications meant to be taken long term? → Is microdosing GLP-1s effective for weight maintenance? → How do strength training and lifestyle affect GLP-1 results? Sponsored By: → Puori | Go to https://puori.com/DRTYNA and use the code DRTYNA at checkout to get 32% off your first protein subscription order and get a free shaker worth $25. → BIOptimizers | BIOptimizers is having its New Year New You sale, and you may get up to 26% off select products, plus up to 45% off select bundles. Visit https://bioptimizers.com/drtyna and use code DRTYNA at checkout to get the best deal on Masszymes and all BIOptimizers products. → VivaRays | Go to https://VivaRays.com and use code DRTYNA for a special discount. On This Episode We Cover: → 00:00:00 - Introduction → 00:00:50 - Chronic illness basics → 00:05:20 - Obesity and genetics → 00:12:59 - It's more than willpower → 00:15:21 - Weight loss statistics → 00:17:04 - Peptides, gut motility. And SIBO → 00:24:28 - Weight regain rate → 00:29:39 - Medication vs behavior → 00:34:09 - Limits of GLP-1s → 00:35:59 - Long term use → 00:39:36 - Treating obesity → 00:45:52 - Metabolic health → 00:49:20 - Solutions → 00:58:55 - GO TO THE GYM Show Links: → Calocurb: Go to Calocurb.com/DRTYNA and use code DRTYNA for 10% off → Weight Regain After Cessation Of Medication For Weight Management: Systematic Review And Meta-Analysis → Weighting on Methane: Weight Loss Medications Associated With Increased Incidence of SIBO Further Listening: → EP. 212 | Obesity Isn’t A Willpower Problem: The Role Of GLP-1s | Dr. Spencer Nadolsky → EP. 208 | This Natural GLP-1 Stimulator Actually Works | Calocurb with Sarah Kennedy → EP. 196 | The Answer Is The Gym | Quick + Dirty Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Transcript

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0:00.0	On this episode of the Dr. Tina show, we are going to be jumping into this latest scientific
0:04.8	publication that has come out recently. It's all about the weight regain after GLP-1s. It came out
0:10.6	in the British Medical Journal very recently. The internet is all ablaze. Everybody is having a field
0:16.5	day, of course. And we got to cover this. Even though I'm fairly done talking about this JLP1 conversation
0:24.0	for a hot minute. I need a break, but this pulled me back in because this is a perfect example
0:29.9	of people being intentionally ignorant, and we need to talk about it. It's a big game of no shit Sherlock, basically.
0:38.3	So without further ado, let's jump in.
0:40.9	You are tuned into the Dr. Tina Show with Dr. Tina Moore.
0:44.3	For more, visit Dr.tina.com.
0:49.8	The article is titled,
0:51.6	Weight Regain After Cessation of Medication for Weight Loss Management.
0:55.2	It's a systemic review and a meta-analysis.
0:57.5	They basically took a bunch of studies going way, way back of all the different types of GLP1
1:03.6	medications, the different in Creighton medications, and looked at overall what were the outcomes.
1:12.3	And the results were this paper.
1:15.7	So the 922 titles screened 37 studies, 63 intervention arms,
1:22.9	9,341 participants were included.
1:26.6	Average treatment duration was 39 weeks.
1:29.5	The average follow-up was 32 weeks.
1:31.5	The average monthly rate of weight regain we're going to talk about.
1:35.9	There was a lot of weight regain.
1:37.7	And I want to preface this with some understanding, some definitions, and also some just very basic common sense.
	...

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