Unpacking GLP-1s: A New Approach to Weight Health with Ashley Koff

Well Beyond 40

JJ Virgin

Nutrition, Fitness, Health & Fitness

4.5 • 1K Ratings

🗓️ 11 February 2026

⏱️ 48 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

What if the goal wasn't just to lose weight, but to achieve a balanced "weight health ecosystem"? In this episode, I speak with Ashley Koff about how ultra-processed foods, under-fueling, and disrupted hormones have shaped today’s metabolic crisis—and why weight loss alone is the wrong goal. Ashley shares her deeply personal journey and her science-backed framework for understanding weight health, including a clear, honest conversation about GLP-1 medications and how to use them responsibly. Ashley Koff, RD, is the USA Today bestselling author of Your Best Shot (HarperOne) and founder of The Better Nutrition Program (BNP). With over twenty-five years of experience, Ashley’s helped redefine how we approach sustainable, lasting weight health. In her new book, Your Best Shot, Ashley introduces weight-health hormones (GLP-1, GIP, CCK, PYY) and offers the first-ever system for assessing and optimizing these hormones, whether you’re using GLP-1 medication or not. It’s a game-changer for anyone who’s felt stuck, blamed themselves, or been failed by traditional dieting. What you’ll learn: (02:10) Why ultra-processed foods undermine satiety and metabolic health. (08:05) How dieting and under-fueling can damage digestion, hormones, and muscle. (13:40) What “weight health” means and why weight alone misses the real problem. (15:30) How GLP-1 and other incretin hormones regulate appetite, fat storage, bone, and metabolism. (17:45) Why enriched and ultra-processed foods leave the body under-resourced. (21:00) How GLP-1 medications work differently from the body’s natural hormone signals. (24:10) Why fatigue, digestive issues, and muscle loss can happen on GLP-1s when dosing and nutrition aren’t optimized. (30:20) Whether it’s possible to come off GLP-1 medications and what sustainable success actually looks like. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/yourbestshot → BIOptimizers | Right now, you can save 15% at https://bioptimizers.com/jjvirgin and use the code JJVIRGIN. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

Click on a timestamp to play from that location

0:00.0	There once was a woman who lived in a shoe.
0:03.0	A size too snug, but what could she do?
0:06.0	But that's not where her story ends.
0:08.0	Thanks to a little help from her Experian friends,
0:11.0	she got her score into much better shape
0:13.0	and relocated to a box fresh new place,
0:16.0	with room to grow and a mortgage to suit.
0:19.0	Now, she lives in a spacious four-bedroom cowboy boots. Better your
0:23.7	Experian credit score to help get mortgage ready. Experian, better your score, better your story.
0:30.1	I'm Kyle Wood, host of Fun Facts Daily. We all know the Winter Olympics have thrilling competitions,
0:35.4	but the history of the sports is more odd and interesting than you might realize.
0:39.3	Like archaeologists have found skis that are over 8,000 years old, meaning that people in Russia and Scandinavia were skiing before the Great Pyramids were built in Egypt.
0:49.3	Fun Facts Daily is covering all the stuff you never realized you always wanted to know about the Winter Olympics and hundreds of other topics.
0:57.1	So follow Fun Facts Daily wherever you get your podcasts.
1:00.7	Life's full of big money decisions. Dividend versus growth stocks. Tapping home equity, even navigating tariffs.
1:07.5	And for every smart tip out there, there's another one that sounds smart, but isn't.
1:11.7	That's where NerdWallet's Smart Money podcast comes in. I'm Sean Piles, a certified financial
1:16.2	planner professional. And I'm Elizabeth Ayola. On NerdWallet Smart Money Podcasts, our finance
1:20.9	journalists do the homework so you can make confident wealth building moves. Whether you're building
1:25.4	your portfolio or protecting it, we've got the facts and a little fun
1:29.1	along the way. Follow NerdWallet Smart Money Podcasts on your favorite podcast app. My first job was working in an ad
1:35.0	agency. Kellogg's was our client. And then we had two new cereals. One was called Smart Start and one was
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from JJ Virgin, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of JJ Virgin and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.