TWiV 954: Speculating sarbecovirus spillovers with Michael Letko

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 13 November 2022

⏱️ 110 minutes

🔗️ Recording | iTunes | RSS

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Summary

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) ACE2-dependent sarbecovirus in Russian bats (PLoS Path) Letters read on TWiV 954 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula Kathy – APODs Jupiter, Lunar Eclipse Blood Moon, Ice Giant Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life) Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1 Listener Pick Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.2	From microbe TV, this is twiv this week in virology, episode 954 recorded on November 11th,
0:19.6	2022. I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:26.1	Joining me today from Fort Lee, New Jersey, Dixand et Palmier.
0:31.1	Hello everybody. It's raining outside. So this is the storm that's moved up from Florida
0:38.1	and is now drenching the Appalachian Mountains and causing massive flooding and downing trees
0:44.9	and knocking out electrical systems. It's just a big mess out there right now. But I guess we could
0:51.3	use the water so never refuse rain because you never know when the next time it might rain.
0:58.0	Well said, Dixand, I like that. I'm also joining us from Madison, New Jersey, Brienne Barker.
1:04.4	Hi, great to be here. Unsurprisingly, I have basically the same weather as Dixand. It is raining
1:10.9	here too. 63 Fahrenheit, 17 Celsius. Good day to me inside. From Austin, Texas, Rich Condit.
1:18.8	Hi there. 53 degrees and cloudy. It was, we have a really steep cold front coming through.
1:29.1	It was a couple hours ago. It was 20 degrees warmer. Right. And we've gotten much less rain with this
1:35.4	than the it was really disappointing. I was hoping for a real show, but yeah.
1:41.3	It's funny. I so associate you with Florida. I was going to ask you how you did with the hurricane.
1:50.0	I have friends who have coped with it, including my brother. He's in the Jacksonville area on the coast.
2:00.9	And then my sailing buddy Henry Baker has a beach house near St. Augustine and that's where he keeps
2:07.6	his boat. They came through okay. But if you look at what happened to the beach, there was some
2:13.7	pretty significant erosion. Well, so joining us from Ann Arbor, Michigan, Kathy Spindler.
2:20.5	Hi everybody. Here it's 64 degrees. Nor region weather app says it's 16, which would mean it's
2:29.4	61. So it's somewhere between 61 and 64. But I'm going to tell you all these temperatures in
2:33.5	Fahrenheit. So you know, earlier in the week, the forecast was for yesterday to be 70 and today
	...

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