TWiV 953: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 12 November 2022

⏱️ 55 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High demand for Amoxicillin causing shortages amid RSV surge (Washington Post) Epidemiologic and clinical features of children & adolescents with monkeypox (CDC) Low risk of SARS-Cov2 transmission by fomites (IDSA) Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID) Impact of community masking on COVID-19 (Science) Remdesivir fact sheet for providers (Veklury) Protection against Omicron from vaccination & previous infection in prison system (NEJM) Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) Bebtelovimab for high-risk outpatients with COVID-19 (OFID) Imprinted SARS-CoV-2 immunity induces convergent Omicron evolution (bioRxiv) PAXLOVID patient eligibility screening checklist (FDA) Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? (Cell) Bebtelovimab fact sheet for providers (FDA) Modeling the effects of global vaccine sharing on the COVID-19 pandemic (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 953 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is twiv this week in virology episode 953 recorded on November 9th,
0:20.4	2022. I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:26.5	Joining me today from New York, Daniel Griffin. Hello everyone. Well we're all back home now,
0:33.4	right Daniel? We are all back. Well you're you're back from your global Trump. I'm back from
0:38.8	just Seattle. So where I also picked up a little bit of SARS-CoV-2. Just a little bit.
0:48.0	There's nothing nothing like Pax Lovid to interrupt its work. All right well we'll be talking
0:52.8	about that today but let's let's get right into it. I don't know if you know but this is our 140th
0:58.8	clinical update. Wow. It's really kind of amazing. So let us start with the quotation,
1:04.3	learn from yesterday, live for today, hope for tomorrow. The important thing is to not
1:11.9	is not to stop questioning. And so that's Albert Einstein. Just you know it's way things and I
1:18.8	think it's really important for us. And I was reading another article today that I'll talk about
1:22.8	next time. You know we think we've got things sort of figured out and then another another study
1:27.4	comes along and it allows us to ask is that really true? And I definitely am learning a lot when we
1:33.9	do the ID Pusscast with Sarah Dogg and we go through so many of these papers that challenge the
1:40.0	dogma. Everything that I was taught with such a pro-brem. I am definitely much more humble now as
1:48.6	the years go by. But let's get right into it with polio. This was raised in the context of polio
1:54.9	when the CDC was requesting more flexibility in its ability to hire experts to help when there's
2:00.7	a problem. So despite having a multi billion dollar budget, the agency doesn't have authority
2:07.2	from Congress to hire consultants in a timely way when an urgent situation rises. So well,
2:13.7	Linsky plans to appeal to Congress to allow for flexibility to do this kind of hiring in a crisis.
2:19.6	Similar to the authority vested in some other federal agencies. So let's say for instance there's
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