TWiV 955: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 19 November 2022

⏱️ 47 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Four things to know about RSV (Gates Foundation) The burden of RSV in healthy term-born infants in Europe (The Lancet) Diagnostic accuracy of rapid tests for Ebola (CMI) Accuracy of self-collected swabs for diagnosis of Monkeypox (CID) Tecovirimat is effective against human monkeypox virus in vitro (Nature) Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine) SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases) Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications) Maternal antibody response and transplacental transfer following infection or vaccination (CID) Impact of community masking on COVID-19 (Science) Lifting universal masking in schools (NEJM) Bebtelovimab fact sheet for providers (FDA) Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv) Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ) Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA) PAXLOVID patient eligibility screening checklist (FDA) Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv) Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine) Remdesivir fact sheet for providers (Veklury) Twice daily oral zinc in the treatment of patients with COVID-19 (CID) Cognitive deficits in long COVID-19 (NEJM) Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications) Long-lasting symptoms after an acute COVID-19 Infection (JAMA) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 955 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From microbe TV, this is Twib this week in virology episode 955 recorded on November 17th, 2022.
0:21.2	I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:26.0	Joining me today from New York, Daniel Griffin. Hello everyone. Daniel, is this time of year
0:33.0	busy as usual or more so than usual? You know, it's it's busier than usual actually. I have to say
0:40.6	we've been having issues and people probably aware of this. Not only are the children's
0:46.3	hospitals overloaded, but even some of our adult ERs where there isn't even enough room in the
0:52.3	waiting room, we have instances where they've said, you know what? Why don't you just give us your
0:55.6	phone number and go wait in your car, which is really shocking, right? People boarding in the
1:00.6	emergency rooms. Yeah, this will get into it, but we are seeing a really massive early upspike
1:08.9	in a lot of our respiratory pathogens. But let's get right into our quotation, better a cruel truth
1:17.4	than a comfortable delusion. And that's by Edward Abbey. I was earlier today on the Brian
1:25.2	Laire show, National Public Radio. Apparently, we're still friends despite my mispronunciation of
1:31.3	the fancy French d'Orte-Targette, my comments about his go-tte, and my other reference to his
1:38.2	social media referencing of information. But I think we're still good friends. So at least he
1:43.9	invited me back. Maybe they couldn't fill the spot. But he asked me this question, what should
1:50.0	we do going forward? And this will be the last episode that drops before Thanksgiving here in
1:56.4	the United States. And my advice was, don't put your head in the sand, don't just decide that
2:03.5	you're done with what's going on and ignore the truth. Use the truth, use the science, use the
2:08.6	facts. That's going to allow you to have a better, safer holiday coming up. So let us jump right
2:16.2	into influenza. We are not doing great when it comes to vaccinations and we're not doing great
2:22.7	when it comes to the numbers. So those numbers are really skyrocketing. We're also seeing issues
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