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This Week in Virology

TWiV 888: Molnupiravir with Richard Plemper

This Week in Virology

Vincent Racaniello

Racaniello, Virus, Virology, Infection, Microbe, Infectious, Medicine, Microbiology, Science & Medicine, Vincent, Twiv, Pathogen

4.8 β€’ 2.2K Ratings

πŸ—“οΈ 14 April 2022

⏱️ 90 minutes

🧾️ Download transcript

Summary

Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferrets (Nat Commun) Letters read on TWiV 888 Timestamps by Jolene. Thanks! Weekly Picks Brianne – BioRender Poster Builder Alan – Hexbug cat toys Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine Listener Picks Sue – American Visionary Art Museum Frazer – Vaccine trial for killer elephant virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.4

From micro TV, this is twiv this week in virology episode 888 recorded on April 12th,

0:20.8

2022. I'm Vincent Racken yellow and you're listening to the podcast all about viruses

0:27.2

joining me today from Western Massachusetts, Alan Dove. Good to be here and it's um 62 Fahrenheit

0:35.4

the moment, mostly cloudy. We had some rain earlier, but we're in that that spring phase of,

0:41.6

you know, sometimes golden rainy, sometimes threatening to be nice weather. Can you imagine if

0:46.8

it had been August 8th today? Yes, that would have been perfect. 888 also joining us from

0:52.6

Madison, New Jersey, Brienne Barker. Hi, great to be here. I have the other type of spring

0:58.8

weather in that it is 70 Fahrenheit, 21 Celsius and beautifully sunny outside. I don't know what

1:06.4

it is. When I came this morning, it was raining and now I haven't looked outdoors. So I have no idea

1:12.9

if it's nice. Yeah, the weather says it's sunny. We have a guest today who is returning for

1:18.5

a second time. He is from Atlanta, Georgia, Richard Plemper. Welcome back. Thank you. I'm very glad

1:24.6

to be here. So I last recorded with you in October 2019 at Georgia's Georgia State University.

1:35.1

And there have been no interesting developments in virology since then. So we have you back on

1:40.0

to catch up. I didn't release that episode until the following July because in January,

1:45.1

we started doing all COVID. One of the things we did is a paper of yours from, I don't know,

1:55.2

2021, yeah, showing that Monu peer-reviewed blocks transmission and ferrets. I said,

2:03.5

we'll have to get Richard back. So here we are, Richard. Welcome back.

2:07.6

Yes, thank you. When you were in Atlanta, we talked actually about the drag, which was then

2:14.6

not called Monu peer-review at a study that we had just done against influenza virus.

2:20.3

And so we demonstrated in the ferret model that what is now called Monu peer-review is actually

2:26.7

very early efficacious influenza. And at the time that was interesting, but nobody knew

...

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