TWiV 1127: Giving prions the (zinc) finger

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 30 June 2024

⏱️ 113 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor’s subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Pentagan anti-vac campaign to undermine China (Reuters) NY governor subway mask ban (AP News) Colorado bat facility sparks outbreak fears (Science) House NIH budget bans gain of function research (Science) Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) Letters read on TWiV 1127 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking Listener Picks Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the Podcast About Viruses, the kind that make you sick.
0:07.0	From Microbe TV, this is Twive this weekend virology.
0:16.0	Episode 1127, recorded on June 28th, 2024.
0:24.1	I'm Vincent Rachinello and you're listening
0:26.1	to the podcast, all about viruses.
0:29.7	Joining me today from Fort Lee, New Jersey, Dixon, DePomey.
0:35.0	Hello, Vincent, and then hello everybody else who's on this show,
0:39.0	and that happens to be another person, but I don't want to mention their name
0:41.7	because I'll step on his lines.
0:44.0	It's a beautiful day.
0:47.0	It's an unbelievably beautiful day out there today.
0:51.0	It is almost zero humidity. It's actually a little bit chilly. Just consider last week for instance. I monitor the temperature in my local trout streams and one of them for the first time in my memory
1:07.4	hit 90 degrees. A trout stream that's 90 degrees. That doesn't work. We're at the surface at the surface.
1:15.5	No, it's hard to measure it. But you measure it at the bottom of the river.
1:19.1	So the trout is not very happy. Anyway, it's all pretty homogeneous in terms of
1:23.0	The trouts are not happy at that temperature.
1:25.0	Unhappy is the least of, I mean they might die.
1:29.0	You could get a fish kill at that temperature for trout.
1:33.0	And for some lakes too, because there's not a lot of oxygen
1:36.3	you can dissolve in the water at 90 degrees, right?
1:39.6	And that's the biggest problem.
1:40.6	So at any rate, other than that, there's such a contrast compared to that. Quite wonderful.
	...

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