TWiV 1126: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 29 June 2024

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC ACIP for RSV (CDC) This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom) Revised RSV vaccine recommendations (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Local and systemic response dynamics to SARS-CoV-2 infection (Nature) Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience) Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine) Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology) Long COVID defined by patient phenotype (CIDRAP) Three distinct symptom-based post-COVID condition phenotypes (JID) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1126 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This Week in Virology, the Podcast About Viruses, the kind that make you sick.
0:07.0	From Microbe TV, this is Twive, this week in Vyrology.
0:15.0	Episode 1126, recorded on June 27, 2024. I'm Vincent Rachinello and you're listening to the
0:25.2	podcast all about viruses. Joining me today from New York, Daniel Griffin.
0:31.3	Hello everyone.
0:34.0	I see some viruses on that bow tie, don't I?
0:38.0	You do and they've got these spikes sticking out all over.
0:41.0	I wonder what it could be. I think it's a SARS-Covey too? I well it's
0:46.0	definitely SARS-Covey it's hard for me to tell like you know whether it's the one or
0:50.3	the two considering this was made prior to 2019 probably the
0:57.1	SARS Coe one right version version one I haven't seen that one before that's a new one. Yep. Very good. All right well not sure how many Kurt Vonnegut fans we we have but
1:09.9	perhaps to lighten the mood before we get into things.
1:14.0	True terror is to wake up one morning and discover that your high school class is running the country.
1:20.0	So Barnaby just graduated, my youngest, my 19-year-old just graduated from high school, you know, so I'm looking out at his class.
1:30.0	Maybe not as terrifying if that class runs the country compared to my high school
1:34.8	class because I was a member of that high school class.
1:37.7	So what could be more frightening?
1:40.8	Lots going on with RSV. So it's actually my cousin Peter Gates text me the other morning.
1:48.0	Dan, what do you think? So, well, we've covered the durability of the some of the RSP vaccine.
1:56.1	So the G.S. K's vaccine, Erexby about 68% effective over 23.3 months in a clinical trial.
2:04.6	Pfizer's Abrizvo was 78% effective after 16.4 months,
2:10.3	so really good, holding kind of steady. And steady and then you know everyone's of course
	...

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