TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 20 August 2023

⏱️ 116 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) VITT-like disorder after adenovirus infection (NEJM) The clot thickens (TWiV 842) Lessons from VITT (Nat Rev Immunol) Pan-sarbecovirus neutralizing mAb (Sci Adv) Letters read on TWiV 1037 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope Brianne – Question Mark in Space? Kathy – Quammen interview with Walter Isaacson Rich – Chrome Music Lab Vincent – Matters Microbial Listener Picks Tom – The (second) deadliest virus Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III) Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is Twiv, this week in virology, Episode 1037 recorded on April 18, 2023.
0:21.4	I'm Vincent Racken-Yellow and you're listening to the podcast, all about viruses.
0:26.5	Joining me today from Fort Lee, New Jersey, Dixandet-Pomye.
0:31.2	Hello, everybody. It's a beautiful day. It's low humidity. The temperature is in the low 80s,
0:38.0	high 70s, depending on where you're at. There are puffy little clouds in the sky.
0:44.8	There's no rain. We've had some rain and the temperature is very tolerable indeed.
0:51.6	Also joining us from Ann Arbor, Michigan, Kathy Spindler.
0:56.3	Hi, everybody. Here it's 73 Fahrenheit, 22 Celsius, and this morning, it was 54 degrees.
1:05.5	It's been in the 50s last couple of days and it's going to keep being in the 50s overnight.
1:11.4	It's amazing for August. Also joining us from Austin, Texas, rich condit.
1:16.6	In contrast.
1:21.4	Hi, everybody. It's 103.
1:27.0	Bright blue skies. We have seen rain in weeks. There's really nothing in the forecast.
1:38.6	It's going to be 100 degrees for the next two weeks. Maybe a little dip into south of 100.
1:44.8	I don't know. We are seven inches behind in rainfall, which means we have about 75% of normal.
1:54.2	We are in stage two water restrictions and the lake is bottomed out. It's just delightful here in
2:02.7	Texas. You can't go rowing anymore? No, not that lake. The main reservoir, Lake Travis.
2:09.8	And bottomed out is an exaggeration. However, it's really low.
2:15.6	Also joining us from Madison, New Jersey, Brian Barker.
2:20.6	Hi, it's great to be here. It is 78 Fahrenheit, 26 Celsius here. It's pretty lovely out.
2:28.0	Although earlier this week, I was trying to figure out if I had any tickets to the arc.
	...

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