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The Human Upgrade with Dave Asprey

This Is Your Brain on 2025: The Biohacker’s Guide to Mental Clarity & Mood | Dr. Drew Ramsey : 1263

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.67.3K Ratings

🗓️ 25 March 2025

⏱️ 75 minutes

🧾️ Download transcript

Summary

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself? 

In this episode, Columbia University psychiatrist and nutritional neuroscience pioneer Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain. 

You’ll explore the cutting-edge science of neuroplasticity, discover how movement and social connection trigger brain growth, and learn why food is still your most powerful antidepressant. Plus: dancing, psychedelics, kale debates, and why porn is quietly reshaping the male brain. 


What You’ll Discover in This Episode: 

• Why brain fog, anxiety, and mood swings might be signs your brain is inflamed 

• How movement—especially dancing—can literally help your brain grow stronger 

• What your gut has to do with your mental health (and why some “healthy” foods can backfire) 

• The truth about antidepressants, supplements, and why there’s no one-size-fits-all fix 

• Why porn, ultra-processed food, and doomscrolling are silently wrecking focus and drive 

• A new way to think about mental fitness—like a workout plan for your brain 


SPONSORS 

-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.  

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 


 

Resources:  

A Day of Biohacking and Consciousness Event April 12th: https://daveasprey.com/biohacking-and-consciousness/ 

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Drew’s Instagram: https://www.instagram.com/drewramseymd/?hl=en 

Drew’s Linktree: https://shorturl.at/CIIR5 

Danger Coffee: https://dangercoffee.com 

Dave Asprey’s Website: https://daveasprey.com 

Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


Timestamps: 

• 00:00 – Trailer 

• 01:43 – Intro 

• 02:51 – The State of Mental Health Today 

• 04:00 – Nutritional Psychiatry and Personal Experiences 

• 05:21 – Environmental Factors and Brain Health 

• 05:55 – Chemical Balance and Psychiatry 

• 09:19 – Mental Fitness and Connection 

• 14:17 – Modern Brain Challenges 

• 16:26 – The Role of Movement and Dance 

• 22:44 – Sex, Relationships, and Mental Health 

• 34:02 – Microbiome and Mental Health 

• 36:50 – Transitioning to Urban Life and Mental Health 

• 37:29 – The Role of Nature in Mental Well-being 

• 38:14 – Personal Experiences with Gut Health 

• 39:45 – Trial and Error in Mental Health 

• 42:16 – Cognitive Resilience and High Performance 

• 45:37 – The Importance of Family Meals 

• 46:33 – Challenges of Rural and Urban Living 

• 47:53 – Brain Health: Beyond Neurons 

• 49:01 – Neuroplasticity and Mental Fitness 

• 52:50 – Biohacking Mental Health 

• 57:31 – The Role of Serotonin in Depression 

• 01:03:57 – Debating the Benefits of Kale 

• 01:12:03 – Final Thoughts on Mental Health and Resilience 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcript

Click on a timestamp to play from that location

0:00.0

If you're going to spend an hour in a spin class under Florism Lights with somebody yelling at you to stand up in sweat versus an hour at Burning Man dancing, I'll take the Burning Man dancing every single time, and it's probably better for my brain, right?

0:13.3

Someone who doesn't pick up a little ukulele or guitar or sit down on the piano or sing in the car with themselves.

0:19.2

I just think it's like a missed opportunity of a

0:21.2

really powerful neuroplastic tool, which is using more music in our lives. You might think there's

0:26.3

something wrong with your brain, and maybe that's because someone wants you to think there is.

0:31.1

Radical truth, we have a mental health epidemic on our hands. Studies show that people today

0:36.7

are more anxious, more distracted, and more exhausted than ever.

0:40.0

And it's not an accident.

0:41.3

Your food, hijacked.

0:42.7

Your neurotransmitters, manipulated.

0:44.8

Your mental health, a billion-dollar industry that doesn't want you to ask the right questions.

0:49.6

Dr. Drew Ramsey has spent decades inside the system, and now he's exposing it.

0:54.1

The real reason depression

0:55.4

rates have doubled and why the standard treatments aren't working, how food, movement, and

0:59.7

connection can rewire your brain without a prescription. The psychedelics, pharmaceuticals,

1:04.5

and brain hacks that actually work and the ones that are pure marketing. This isn't just

1:08.7

about mental health. It's about mental sovereignty.

1:11.9

Because if you don't own your mind, the world will rent it out. Your thoughts create your reality.

1:17.5

So what reality will you choose to build? I don't need you to exercise for 150 minutes a week to

1:23.5

beat clinical depression. I'd like you to go dancing this Friday night because there are some

1:27.6

interesting studies looking at your movement. All movement is great. What does it do to your breath?

1:33.6

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