4.6 • 7.3K Ratings
🗓️ 27 March 2025
⏱️ 83 minutes
🧾️ Download transcript
For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?
Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15, that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place—U.S. Navy dolphins that were outliving their wild counterparts by decades—this forgotten fat is now shaking up the scientific community.
So why hasn’t anyone told you about it?? Decades of misguided dietary advice stripped this crucial nutrient from our food system, leaving an entire generation unknowingly deficient. Even worse, pregnant women have been some of the MOST hurt from this cruel change to our modern diet. Now, cutting-edge research is proving that C15 plays a critical role in cellular stability, mitochondrial function, and total mental health.
What You’ll Learn in This Episode:
• The first new essential fatty acid discovered in nearly 100 years—and why it matters
• How dolphins led to one of the BIGGEST breakthroughs in human nutrition
• Why the removal of C15 from our diets is accelerating aging
• The surprising connection between C15 and mental health
• How this “missing” fat could outperform some of the biggest longevity drugs today!
• What foods naturally contain C15—and should you supplement it?
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Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Fatty15 Instagram – https://www.instagram.com/fatty15/
• Fatty15 Website: www.fatty15.com
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
00:00 – Intro
00:34 – Meet Dr. Stephanie Venn-Watson
00:46 – Discovering C15 in Navy Dolphins
01:58 – Challenges and Skepticism
04:21 – Scientific Validation and Research
06:59 – C15’s Impact on Human Health
27:43 – Big Data, AI, and Longevity Research
36:08 – C15 as a Longevity Nutrient
42:14 – The Navy’s Role in Fatty 15
43:03 – Epigenetic Aging and Lifespan
44:51 – Nutritional Guidelines and C15 Deficiency
50:41 – Mental Health and Endocannabinoids
51:33 – Dairy, Fats, and Nutrition History
56:38 – Fatty 15 in Skincare and Supplements
01:03:58 – Regulatory Changes in Nutrition
01:11:26 – Gender Differences in Fatty Acids
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0:00.0 | There's problems with milk protein, but milk fat is like the most important thing. |
0:04.3 | If mom is C-15 deficient, then her milk is C-15 deficient and her baby's C-15 deficient. |
0:11.0 | If we have C-15 deficiencies, we develop a new form of cell death called feroptosis that |
0:15.8 | accelerates our aging. So our job to get C-15 back in our lives, slower aging rates, and then optimize C-15 |
0:22.8 | to get us a little closer to your goal, just to live longer. Study showed that people who have more C-15 |
0:28.2 | on their complex lipids had younger biological ages than their chronological age. How much younger? |
0:34.6 | Dr. Stephanie Venn Watson isn't just a scientist. She's a veterinarian, |
0:38.0 | public health expert, and award-winning lipid researcher whose biggest breakthroughs started in the |
0:42.5 | most unexpected place, studying the health and longevity of dolphins for the U.S. Navy. |
0:46.7 | She discovered that the healthiest, longest-living dolphins had something in common. Higher |
0:50.8 | levels of a rare, overlooked fat that protected their cells, boosted their |
0:54.4 | metabolism, and kept them biologically younger. The twist? Humans used to get this same essential |
1:00.0 | fat in our diets. But thanks to modern food processing, we've nearly lost it all. This essential |
1:04.4 | fat is known as C-15-0, and it may just be the missing link to cellular health, sharpened brain |
1:09.6 | function, and one of the ultimate keys to slowing down aging. |
1:14.5 | You're listening to The Human Upgrade with Dave Asprey. |
1:20.9 | Stephanie, thanks for coming. |
1:22.8 | Overlooked fat that protected their cells, boosted their metabolism, and kept them biologically younger. |
1:27.6 | The twist, humans used to get this same essential fat in our diets. |
1:32.0 | But thanks to modern food processing, we've nearly lost it all. |
1:34.7 | This essential fat is known as C-15-0, and it may just be the missing link to cellular health, |
1:39.8 | sharpened brain function, and one of the ultimate keys to slowing down aging. |
... |
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