There’s a Lot of Unknown in Life

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

Personal Journals, Health & Fitness, Society & Culture

4.9 • 3.7K Ratings

🗓️ 30 December 2025

⏱️ 60 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com/messy Ridwell - Go to ridwell.com/messy to get $10 off your first pickup or mail-in kit. Because sometimes the best way to do more is just to start with something small that you know makes a difference. Hexclad - Take advantage of HexClad’s Holiday Sale! Head to hexclad.com/MESSY for Up To 50% Off! #hexcladpartner

Transcript

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0:00.0	Hi, I'm Christina Applegate. And I'm Jamie Lynn Sigler. And this is messy.
0:10.4	The following message is brought to you by Novartis. Hi, I'm Jamie Lynn Sigler. When it comes to
0:20.6	relapsing MS treatments, your choice
0:22.6	matters. That's why talking to your doctor about your options is a big deal. But how do you know
0:27.2	what to ask? Figuring that out can be daunting. That's why I partner with Novartis to create an
0:32.9	MS treatment decision guide. It's packed with helpful info and questions for your doctor to help make an informed decision.
0:39.6	Trust me, the more prepared you are, the more confident you'll feel.
0:43.1	Download the guide right to your phone, only at Treatmentdecisionguide.com.
0:56.3	Hey, everybody. Welcome to Messy.
0:58.1	This is Jamie and Christina.
1:08.1	And we're here today to talk to you and answer you and answer your lovely emails that you so generously wrote to us.
1:10.0	So we're excited to talk to you.
1:12.9	And the first email is from Diane.
1:24.4	Diagnosed in 1979 with RMS, both my daughters also have it. When I was having a bad day,
1:31.2	I said I'm having emmesey day without the E. Not funny, but even though we have MS, MS doesn't have us. Stay strong. Wow, Diane. Oof. Dian.
1:38.3	1979 and both your daughters, well, sending you three beautiful women a lot of love.
1:45.3	Yeah, that's crazy.
1:46.9	I was born in 71.
1:49.0	Holy shit.
1:51.1	You're old, Diane.
1:54.9	That is a long time.
1:56.2	Just kidding, Diane, you know me.
	...

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