The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 21 February 2025
⏱️ 85 minutes
🧾️ Download transcript
Summary
Could a single molecule be the difference between vibrant longevity and early decline?
Dr. Andy Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD.
This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it?
Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity.
Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer.
What You’ll Learn:
• The #1 reason your NAD is disappearing—and how to fix it
• Why NAD is the missing link in energy, DNA repair, and disease prevention
• The hidden enzyme (CD38) that’s sabotaging your longevity
• How to supercharge mitochondria, optimize blood flow, and fight aging at the source
• Why the supplement industry has it wrong—and the best way to boost NAD naturally
• The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Andrew Salzman’s Instagram – https://www.instagram.com/andrew_salzman/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
00:00 Trailer
01:07 Introduction and Episode Overview
02:29 Meet Dr. Andy Salzman
02:36 From Physician to Researcher
03:39 Pharmaceuticals vs. Nutritionals
04:17 The Role of NAD in Longevity
06:32 Challenges in Longevity Research
12:58 Understanding NAD and PARP
14:34 NAD’s Impact on Health
23:19 Gut Health and Longevity
27:43 Innovations in NAD Supplementation
41:27 Customer Feedback and Product Effectiveness
42:41 Surprising Benefits of NAD for Sexual Health
44:47 NAD and Vascular Health
48:46 NAD’s Role in Aging and Longevity
54:03 NAD and Lifestyle Choices
01:03:02 NAD and Cognitive Function
01:06:18 NAD and Exercise
01:13:42 NAD and Sleep
01:21:54 Final Thoughts on NAD and Longevity
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Transcript
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| 0:00.0 | What is NAD? |
| 0:01.0 | What is NAD? |
| 0:02.0 | NAD is a small molecule. |
| 0:03.0 | It's the centerpiece of biology, and it really does three things in our body. |
| 0:06.0 | Gives us our energy, protects us against oxidants, and it saves us from cancer. |
| 0:10.0 | We used to think about diseases as being sort of these isolated instances of bad luck. |
| 0:15.0 | Oh, I got diabetes. |
| 0:16.0 | Oh my goodness, I got cancer. |
| 0:18.0 | But that's the 1950 ways to look. |
| 0:20.0 | Today we have to see these really as |
| 0:22.1 | an integrated whole. Why do we get sicker as we get older? The aging process is a core |
| 0:27.5 | fundamental derangement that then spawns injury in all these different organs. If you happen to have |
| 0:33.2 | an injury in your knee, suddenly you have arthritis. But if it's really not arthritis, what it is |
| 0:38.4 | fundamentally is aging. I look at it like this. If I age, it's my fault. A lot of people think |
| 0:44.6 | that aging starts when you're 60 and 70, but actually aging doesn't start when you're 65. |
| 0:49.2 | Given what we know with AI, with new research, all the work you've done in your life, how long |
| 0:53.7 | do you think humans could live if we just pull, all the work you've done in your life. How long do you think humans |
| 0:54.6 | could live if we just pull it all the stops? You're listening to the Human Upgrade with Dave |
| 1:00.5 | Asprey. This is going to be a really fun episode recorded live in the studios here in Austin, |
| 1:09.3 | Texas, because I like talking with really, really smart people who've done a lot of big things in |
| 1:16.1 | the world. |
| 1:16.7 | There's so much we can learn. |
... |
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