4.6 • 7.3K Ratings
🗓️ 20 February 2025
⏱️ 83 minutes
🧾️ Download transcript
Welcome to the metabolism masterclass!
Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast.
From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity.
What You’ll Learn:
• The #1 driver of insulin resistance—and why most doctors miss it
• Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction
• How fasting, cold therapy, and red light impact your metabolism
• The truth about carbs, seed oils, and why some people can’t gain fat
• How to tell if insulin resistance is wrecking your energy & health
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Benjamin’s new book How Not To Get Sick : https://a.co/d/aADlMWv
• Benjamin’s YouTube Page – https://www.youtube.com/@benbikman
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
SPONSORS:
-Lumiram | Go to http://healthlighting.com/dave to save 10% on your order.
-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Timestamps:
00:00 Trailer
00:52 Introduction to Dr. Benjamin Bikman
02:20 The Battle Against Conventional Dietetics
04:12 Understanding Insulin Resistance
06:29 The Two Paths to Insulin Resistance
10:19 Fasting and Metabolic Health
14:11 Insulin and Cognitive Enhancement
18:16 Identifying Insulin Resistance
30:12 The Role of Insulin in Fat Storage
42:04 Understanding Glucose and Insulin Dynamics
42:26 The Role of Exercise in Glucose Regulation
42:54 AMPK and Muscle Contraction
45:21 Calories In, Calories Out Debate
46:15 The Myth of Calorie Counting
50:13 Ketosis and Metabolic Rate
51:14 Intermittent Fasting and Muscle Preservation
55:21 Insulin Resistance and Ketogenic Diets
01:02:04 Circadian Rhythm and Insulin Sensitivity
01:08:08 Environmental Toxins and Insulin Resistance
01:13:03 The Impact of Seed Oils on Insulin Resistance
01:19:22 Final Thoughts and Resources
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0:00.0 | 70% of all calories consume globally come from starches and sugars. And so the average individual, |
0:05.6 | because they've been told, is eating five or six times a day. It's all carbohydrate heavy. |
0:10.1 | My biggest critics online are the dietetics. And I'm just like, guys, you've done a shitty job. |
0:14.9 | Look at the health of the country. And look at people who eat hospital food. Stop talking. |
0:18.6 | To the average person who wants to lose weight, the traditional view is cut your calories. But if you're not addressing your insulin, |
0:24.5 | that's just going to promote hunger. Hunger always wins. Before you know it, you'll be right |
0:27.8 | back where you were. Without insulin, you die. I've read studies saying that low insulin |
0:32.7 | is four times more deadly than high insulin. If you do some research about insulin and |
0:39.2 | Alzheimer's, you'd want to be on a low-carb diet, but you might want a little squirt of insulin |
0:42.9 | every now and then in your brain because it seems to help. What concerns me is if you take a |
0:47.8 | little bit of insulin and you put it in a nasal spray and you spray it up your nose, |
0:51.9 | it's a way of treating Alzheimer's. So why is it when I raise insulin, |
0:55.6 | my brain works better. You're listening to The Human Upgrade with Dave Asprey. |
1:03.5 | Today we are going to have an amazing conversation with Dr. Benjamin Beekman, or Ben Beekman, who is an absolute boss when it comes to bioenergetics, |
1:17.2 | metabolism, and the way the body actually works. And as you might know, I kind of have a mitochondrial |
1:23.3 | fetish I developed in the late 90s because I had chronic fatigue syndrome and fibromyalgia and |
1:28.9 | brain fog and 300 pounds of weight. And I learned from people in their 70s and 80s who were |
1:36.3 | running a longevity nonprofit group and soon they asked me to run it and I'm the only guy 150. |
1:41.2 | So mitochondria have been at the very center of biohacking. It's like you change the |
1:44.9 | environment around you. So you have control of your biology because your mitochondria listen to the |
1:49.0 | environment. So now we have Dr. Beekman here to talk about what's really going on in there. |
1:54.9 | He's a fantastic teacher, very, very learned human being. And I'm excited to share his wisdom with you today. Ben, welcome to the show. |
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