The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 25 February 2025
⏱️ 72 minutes
🧾️ Download transcript
Summary
Can You Mimic Fasting—Without Actually Fasting?
Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health.
Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food.
Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation.
For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating.
What You’ll Learn:
• The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours)
• The four fasting metabolites that extend life by 96%
• How Mimio mimics fasting benefits—without giving up food
• The real reason over-fasting destroys your metabolism and hormones
• Why traditional longevity drugs (Metformin, Rapamycin) fall short
• Can you build muscle and burn fat at the same time? The science of mTOR & AMPK
• Why Big Pharma doesn’t want you to know about this breakthrough
*** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE ***
Sponsors:
Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Mimio Instagram: https://www.instagram.com/mimiohealth/
• Mimio Website: https://mimiohealth.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Intro
• 00:58 – Fasting & Longevity
• 01:88 – Optimal Fasting Length
• 03:39 – Alternate Day Fasting: Pros & Cons
• 05:50 – Key Fasting Compounds
• 07:34 – Spermidine & Longevity Molecules
• 11:41 – FDA Roadblocks on Natural Compounds
• 15:37 – AI, Big Data & Longevity Research
• 31:19 – Mimio’s Impact on Testosterone & Aging
• 35:16 – Longevity & Death Philosophy
• 36:48 – Biohacking Origins
• 37:03 – Metabolism & Cognitive Function
• 38:35 – Unexpected Effects of Fasting
• 40:43 – Fasting & Circadian Rhythms
• 43:09 – Mimio Science & Benefits
• 45:14 – Mimio in a Daily Routine
• 55:05 – Men vs. Women: Fasting Differences
• 01:02:23 – Future of Nutrition & Biohacking
• 01:07:21 – Conclusion & Discount Code
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Transcript
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| 0:00.0 | One of the things that I'll say we didn't know a lot about back in 2011 was the ideal length of a fast. |
| 0:08.0 | And so what I found is we want to probably go 18 hours and I talked about some longer fasts. |
| 0:13.0 | But then people were over fasting and creating biological stress, almost a starvation response. |
| 0:18.0 | If I start taking Mimeo, this carefully constructed, blended four things, can I stop fasting? |
| 0:24.3 | Nature has given us a lot of these very interesting regenerative states of the body, regenerative pathways that our body naturally uses to heal ourselves. |
| 0:33.7 | The nice thing about the Mimio formulation is that in addition to the clinical studies that we've done on the full formulation, the individual ingredients have, you know, like 100 plus clinical studies out there already on them showing they have all these various effects. For the lifespan extension, for example, P-EA was able to extend lifespan by 24%. OEA was able to extend lifespan in that same range, like 28%. |
| 0:54.6 | Is it true that you've extended lifespan by 96%? |
| 0:59.8 | You're listening to The Human Upgrade with Dave Asprey. |
| 1:06.0 | Chris, I'm really excited to have you on the show because a lot of listeners know back in 2012, |
| 1:14.2 | I started writing about the Bulletproof Diet, which was, I'm going to say, |
| 1:18.6 | the first modern intermittent fasting diet. |
| 1:21.1 | Oh, yeah. |
| 1:21.7 | We're in a couple big books about fasting and a big book about longevity. |
| 1:26.5 | Yep. |
| 1:26.6 | And you're coming out of UC Davis and you've really studied biochemistry and you're now |
| 1:34.1 | looking at details and fasting that no one has looked at throughout history. |
| 1:38.6 | Is it true that you've extended lifespan by 96%? |
| 1:43.5 | Yeah, that is true that you've extended lifespan by 96%. In what that is true that you've extended lifespan by 96%. |
| 1:46.3 | In what? |
| 1:47.0 | In C. Elegans, yeah. |
| 1:48.5 | Okay. |
| 1:48.7 | So, yeah, we'll put that in perspective for people, right? |
... |
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