Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist Eric Christensen.

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The drug of the day today is to Dallafil.

Brand name is Cialis.

As a category, this drug falls within the PDE5 inhibitor category. It is primarily

going to be used for erectile dysfunction. And mechanistically, how that works. So if you remember

PDE5, that is phosphodiesterase 5, and the drug inhibits

that enzyme. So what does that enzyme do? That enzyme, PDE5, breaks down cyclic guanonosophosphateate or cyclic gmp it's often referred to as which is obviously much much easier

so when there's more cyclic gmp around this can help stimulate erection obviously and by using a using a PD5 inhibitor, it essentially helps keep that around.

It prevents that breakdown of this cyclic GMP.

Going back a little bit further, if you're studying physiology, pathophysiology, nitric oxide release is important

kind of during initial sexual arousal. That stimulates that production of cyclic gmp.

And then a PDE5 inhibitor will help prevent that breakdown of cyclic gmp.

So again, primary use, erectile dysfunction, that's what I've seen it used most for in practice.

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