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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Sitagliptin Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

4.9773 Ratings

🗓️ 17 November 2022

⏱️ 13 minutes

🧾️ Download transcript

Summary

Sitagliptin is a DPP4 inhibitor. I discuss the pharmacology of this medication on the podcast.

Which diabetes medication works similarly to sitagliptin? I discuss that further on this episode of the Real Life Pharmacology podcast.

Renal elimination plays a significant role with sitagliptin. I discuss how this impacts the appropriate dosing.

Cost is a significant issue with sitagliptin at this time. In addition, it’s A1C-lowering effects aren’t anything to write home about. I discuss how much it will lower A1C in this podcast episode.

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Transcript

Click on a timestamp to play from that location

0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Derek Christensen.

0:05.3

Thank you so much for listening today. Go check out real life pharmacology.com. Get your free study

0:12.6

guide on the top 200 drugs. Great refresher if you're out of practice or if you're taking board

0:20.0

exams coming up, for example, or in

0:22.1

pharmacology classes, it's a no-brainer to have that 31-page PDF on the top 200 drugs.

0:29.1

So I put in my clinical experience, some of the most important things that come up,

0:34.3

as well as my experience in test-taking, with things that frequently come as well as my experience in test taking with things that frequently

0:40.1

come up there as well so go get that for free simply email we'll get you access to that no

0:45.9

cost to you at all all right the drug of the day today is citaglipton brand name of this medication

0:54.0

is genuvia and this medication is Genuvia.

0:55.3

And this medication is what's called a DPP4 inhibitor.

1:01.6

Now that DPP4 inhibitor name comes from its mechanism of action.

1:08.5

Citiglipton inhibits dipept peptidase 4. This prevents breakdown of incritin hormones.

1:19.6

And if you remember from physiology, so incritin hormones are important in glucagon, insulin, homeostasis,

1:30.6

and ultimately control of blood sugars.

1:34.8

So incritin hormones, a couple examples that you may be familiar with

1:38.6

if you've listened to previous podcasts.

1:42.0

GLP1 is an example of one of those hormones. So if you think about GLP1 agonist

1:49.0

medications, which we have covered previously, that's where that's come from. And Cidoglyptin

1:56.9

works on that pathway to basically increase that g-lp-1 hormone.

2:05.6

In addition, the other incritin hormone is GIP, and that would be glucose-dependent

2:13.3

dependent insulinotropic polypeptide.

...

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