Gabapentin (Neurontin) Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 10 November 2022

⏱️ 16 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this podcast episode, I discuss gabapentin (Neurontin) pharmacology, adverse effects, drug interactions, and much more!

Gabapentin's GI absorption is a little wacky. I discuss on the podcast the clinical effects that this may have on our patients.

Renal elimination is critical to gabapentin. Worsening renal function will significantly impact the action of the drug.

CNS sedation can be a problem with gabapentin, especially in combination with other CNS depressants. I discuss this further on the podcast.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast.
0:03.9	I'm your host pharmacist, Eric Christensen.
0:05.8	Thank you so much for listening.
0:08.3	The drug of the day today is gabapentin, but before we get into that,
0:12.9	I want to make sure you guys go check out Real Life Pharmacology.com.
0:17.1	I've got a free 31-page PDF on the top 200 drugs,
0:21.7	simply for subscribing to the podcast.
0:25.0	We get your email updates when we've got new content available,
0:29.8	so definitely don't hesitate to do that
0:32.0	and get your free PDF of the top 200 drugs.
0:36.0	Great study guide and review.
0:38.3	All right, let's get into that drug of the day today and that is gabapentin
0:43.6	brand name is neronton
0:46.1	and if you have been around since the beginning of the podcast i did cover
0:50.7	this in combination
0:53.0	with uh... pre-gabalin.
0:56.1	But I wanted to dig into some of the specifics about the drug a little bit more,
1:00.9	and it has been four years since I've done it.
1:03.5	So anyway, let's go through Mechanism of Action quick.
1:09.7	Mechanistically, Gabapentin binds and effects voltage-gated calcium channels.
1:17.3	More specifically, if it comes up on an exam or something for you, it is the Alpha-2-Delta-1
1:24.3	subunit, and this action, by binding there and having action on voltage gated
	...

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