The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 1 April 2025

⏱️ 76 minutes

🔗️ Recording | iTunes | RSS

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Summary

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?

In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism.

You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory.

So what’s the one upgrade that can actually reset your gut… for good?

What You’ll Learn in This Episode:

• Why your gut—not your brain—is making most of your decisions

• How 93% of probiotics on the market fail before they reach your intestines

• The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO

• What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it)

• The shocking gut–brain–heart axis connection you’ve never heard of

• Why inflammation, brain fog, and mood swings may start with leaky gut

• Which probiotic strains are clinically proven to improve cognition and mood

• What to do if you want to eat gluten again—or survive American wheat

• How a fermented papaya concentrate could replace your acid reflux meds

• Why optimizing your gut could extend your lifespan by 40%

***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***

Transcript

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0:00.0	You can predict someone's age by a lack of diversity in their gut bacteria.
0:04.0	Without addressing the gut, there's just so many other things that you can't really address.
0:08.0	It's like you can't calm down low-grade inflammation in the body if you have leaky gut and you keep spewing toxins into your bloodstream.
0:15.0	So it's all connected, but the gut is a huge foundation to even things like that.
0:19.0	You already know your gut controls more than digestion.
0:22.3	It shapes your brain, your immune system, even your metabolism. But here's what no one's
0:26.8	telling you. Unhealthy human or in an unhealthy gut, for example, you have your good bacteria,
0:31.8	then you have opportunistic bacteria. You're probably still doing it wrong. You take probiotics,
0:37.0	but then they don't work sometimes. You eat
0:39.1	fermented foods, but they're not enough. You try to heal your gut the way I did, but the problem isn't
0:44.7	what you think. Hannah Kleinfeld has spent years inside the microbiome industry, breaking down what
0:50.2	actually shifts gut health at a biochemical level, And what a huge number of these so-called
0:55.5	gut health products really don't work. Your gut bacteria actually make decisions for you. Cravings,
1:02.0	mood, sleep, that's your gut. Today, you'll learn how to take that power back. And the one
1:07.3	upgrade that actually fixes your microbiome, maybe even for good.
1:11.1	Because if you don't control your gut, your gut controls you.
1:13.9	70 to 80% of our immune system originate in the gut.
1:17.5	And I know that if my gut is not working properly, my brain also won't be working properly.
1:21.9	So if I started by optimizing my brain, but my gut was a mess, I really wouldn't be making any progress.
1:26.8	People talk about there being a gut brain and sometimes a heart brain and then a brain brain.
1:32.2	Is there a connection between the gut brain and the heart brain that you're aware of?
1:36.9	So ask yourself, who's really in control?
	...

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