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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Pregabalin Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 24 August 2023

⏱️ 16 minutes

🧾️ Download transcript

Summary

On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more.



I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin.



Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids.



Pregabalin is most frequently used in practice for neuropathic pain syndromes.

Transcript

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0:00.0

Hey all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacistair Christensen.

0:05.5

Thank you so much for listening today. As always, go check out real-life pharmacology.com.

0:11.2

We got that free 31-page PDF on the top 200 drugs. It's a great study guide, great refresher,

0:17.3

if you're out in practice. No-brainer, definitely to go get that. Simply an email is all

0:22.2

it's going to cost you. We also get you updates when we've got new podcasts and content available as

0:27.4

well. So again, real-life pharmacology.com, a free 31-page PDF on the top 200 drugs. All right,

0:35.4

let's get into the drug of the day today, and that is pre-gabalin.

0:40.7

Brand name of this medication is Lyrica. This medication is historically categorized and was first

0:49.5

approved as an adjunct anti-seizure medication.

0:56.3

So that may be how you see it classified.

0:59.4

I can tell you out in real-life practice,

1:02.2

the majority of times you see this medication,

1:05.7

it is likely being used for analgesic purposes.

1:10.3

And more specifically, it's associated with

1:15.9

neurology and neuropathy, those type of pain syndromes, fibromyalgia, RLS, Restless

1:23.6

Leg Syndrome you may see it used for. So those are going to be probably the most common indications that I've seen in my practice.

1:33.8

Off label, I have seen some wackier uses, anxiety, menopausal symptoms like hot flashes,

1:42.5

that type of situation. I would say I see gabapentin

1:46.4

probably used a little bit more. It's got a similar mechanism of action and things of that nature.

1:51.9

But there are some kind of wackier off-label uses, but again, by far I see it used for neuropathy

1:59.9

and those type of pain syndromes.

2:03.3

Mechanistically, how does this drug work?

...

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