Metabolic Flexibility: A Fullscript Forward Preview

The Root Cause Medicine Podcast

Kate Kresge

Alternative Health, 810564, Medicine, Health & Fitness

4.8 • 581 Ratings

🗓️ 9 October 2025

⏱️ 50 minutes

🔗️ Recording | iTunes | RSS

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Summary

True longevity requires metabolic flexibility, but how can we help our clients get there? This episode previews personalized metabolic health and longevity strategies from Dr. Rob Downey and Monique Class, presenters at Fullscript Forward 2025. Dr. Downey discusses how metabolic phenotyping, stress/HRV context, and GI patterns can inform evaluation, while Monique describes low-dose (microdosed) GLP-1 approaches, titration by response, and gradual tapering within lifestyle-first care model help them achieve impactful results for their clients. The conversation explores objective monitoring (labs, body composition), muscle-preserving movement, and structured workflows that may help patients sustain progress after medication changes. This episode is for informational and educational purposes only.

Transcript

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0:00.0	Well, hello there and welcome to the Roo Cross Medicine podcast. I'm your host for today, Dr. Kate Kresgey,
0:04.4	and we are talking with two incredible clinicians who are presenting at our FullScript Forward Summit next week.
0:10.1	Now, our summit is on longevity, and we at FullScript believe that longevity has three major pillars.
0:15.7	One is inflammation and modulating that to reduce what's called inflamaging. The other is metabolic flexibility
0:22.6	and health. And the third is the ability to create a targeted personalized plan for your clients
0:27.6	that they'll actually use. So those three pillars are what we'll be talking about at Fulsar
0:32.2	Forward. And today we're joined by Dr. Robert Downey and Monique class to give you a little bit of a preview
0:37.0	for some of the things they'll be talking about in the metabolic health track. Now, Dr. Robert Downey and Monique Class to give you a little bit of a preview for some of the things
0:37.7	they'll be talking about in the metabolic health track. Now, Dr. Robert Downey is a functional
0:41.8	medicine doctor. He works at seatworthy medicine in Alaska. He runs a large clinic and what he's
0:46.6	going to talk about is how he phenotypes or classifies patients into different categories
0:51.3	based on measurements he can take in office and with blood labs
0:54.1	and with an assessment of their lifestyle to figure out what interventions are actually going to work for them to increase their metabolic health and flexibility.
1:01.6	Then we're going to talk with Monique class.
1:03.6	Monique is a family nurse practitioner.
1:05.1	She has over 35 years of experience teaching in the fields of function of medicine.
1:08.8	And she's a fantastic person to talk to about the use of things like GLP-1s for things like longevity,
1:15.0	inflammation, and weight management.
1:17.4	She thinks about microdosing GLP-1s and beginning with the end in mind.
1:21.1	So thinking about the taper-off strategy while she's tapering on.
1:24.5	I really loved listening to Monique because you can tell she has a ton of clinical
1:28.3	experience with this and she's gotten really amazing clinical results. So if you want to learn more
	...

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