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Theories of Everything with Curt Jaimungal

Merel Kindt: How One Pill Rewrites Fear Memories Permanently

Theories of Everything with Curt Jaimungal

Curt Jaimungal

Physics, Philosophy, Society & Culture, Science

4.6606 Ratings

🗓️ 6 April 2023

⏱️ 72 minutes

🧾️ Download transcript

Summary

Merel Kindt (psychologist) reveals how memory extinction could permanently eliminate anxiety, PTSD, and phobias. She explores the neurobiological basis of fear, the potential to erase harmful memories, and the ethical challenges of such interventions.- 00:00:00 - Introduction- 00:02:35 - Extinguishing fear- 00:09:30 - Destabilizing memory traces- 00:13:50 - Locating where fear arises- 00:16:43 - Protein synthesis & irrational fears- 00:19:21 - Suppressing innate fears- 00:28:12 - Imaginary exposure & Beta-blockers are key- 00:34:34 - Can we remove happiness?- 00:47:16 - Is trauma necessary to overcome phobias?- 00:56:06 - This eliminates disgust- 01:04:10 - Future challenges of fear extinction workSPONSORS:- New TOE Website (early access to episodes): https://theoriesofeverything.org/- Patreon: https://patreon.com/curtjaimungal- Crypto: https://tinyurl.com/cryptoTOE- PayPal: https://tinyurl.com/paypalTOE- Twitter: https://twitter.com/TOEwithCurt- Discord Invite: https://discord.com/invite/kBcnfNVwqs- iTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802- Pandora: https://pdora.co/33b9lfP- Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e- Subreddit r/TheoriesOfEverything: https://reddit.com/r/theoriesofeverythingRESOURCES:- YouTube Link: https://www.youtube.com/watch?v=u5hmTyu_dt4- Merel Kindt "Cure for Fear" mini-docu series: https://www.youtube.com/watch?v=pM3G6kITdYk&t=0s Theories of Everything with Curt Jaimungal features long-form, technically detailed interviews with leading researchers in physics, mathematics, consciousness, and philosophy, exploring topics at the level of active research. For academics, graduate students, and anyone seeking depth beyond popular science. SPONSOR: I personally subscribe to The Economist. TOE listeners get 35% off the annual subscription. No other podcast has this! https://economist.com/TOE FOLLOW: Substack | Spotify | YouTube | Twitter Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

I was thinking how can we mislead our brain and weaken the fear memory itself.

0:05.0

Emotional memory that underlies anxiety disorders is not a sort of single memory trace, but it is a network.

0:11.0

This changed our whole idea of memory.

0:14.0

This episode, we talk about a groundbreaking intervention for treatment-resistant PTSD, panic disorders, and fear

0:22.3

in general.

0:23.5

Merrill Kindit is a professor of clinical psychology and a pioneer of research in fear extinction.

0:28.6

When I heard about this research, I was flabbergasted that it wasn't getting anywhere near

0:32.7

the press that I thought it should.

0:34.4

This, by the way, is an unreleased episode from approximately two years ago

0:38.0

near the beginning of the Theories of Everything podcast with Merrill Kindit. Forgive my nascency as a

0:43.1

podcaster as I've changed substantially and hopefully substantively in various ways since then.

0:48.6

Most of them, hopefully again, positive. Enjoy. We're here with Merrill Kint of the University of Amsterdam, and she is a professor in

0:57.0

fear extinction, if I'm not mistaken, or at least that's what she studies.

1:00.0

So, Professor, can you give us an overview of your fear extinction research?

1:05.0

That is a long story, so I don't know how much time you have, but I think I have to give you a bit of a background information,

1:15.6

otherwise it's really difficult to understand the research program and why we changed actually our approach from the traditional approach that is taken to tackle irrational fears.

1:31.3

For fear and anxiety disorders and also post-traumatic stress disorder,

1:36.3

cognitive behavior therapy is the most effective treatment.

1:41.3

And even though it is effective, there are also many patients that do not

1:45.7

profit from the treatment but it the yeah the but is really a problem is the high

1:53.6

relapse rate so even after successful treatment there are many patients

1:58.1

that yeah show a relapse.

...

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