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MeSsy with Christina Applegate & Jamie Lynn Sigler

Megan Mullally

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

Personal Journals, Health & Fitness, Society & Culture

4.9 • 3.7K Ratings

🗓️ 30 September 2025

⏱️ 62 minutes

🧾️ Download transcript

Summary

This week Christina and Jamie are joined by Megan Mullally. They discuss how her role as Karen on Will & Grace came to be, understanding family trauma, the comfort of TV, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy. This is an amazing value. CBDistillery - If you’re ready for better sleep, less stress and feeling good in your own skin again, try CBD from C B Distillery. Save 25% off your entire purchase. Visit cbdistillery.com and use promo code MESSY

Transcript

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0:00.0

Hi, I'm Christina Applegate.

0:02.6

And I'm Jamie Lynn Sigler.

0:04.1

And this is messy.

0:10.4

The following message is brought to you by Novartis.

0:18.1

Hi, I'm Jamie Lynn Sigler.

0:19.8

When it comes to relapsing MS treatments, your choice matters.

0:23.3

That's why talking to your doctor about your options is a big deal. But how do you know what to ask?

0:28.1

Figuring that out can be daunting. That's why I partner with Novartis to create an MS treatment

0:33.4

decision guide. It's packed with helpful info and questions for your doctor to help make an

0:38.1

informed decision. Trust me, the more prepared you are, the more confident you'll feel. Download the

0:43.5

guide right to your phone only at treatmentdecisionguide.com.

1:02.8

Hello, everyone. Welcome to Messi. It's Christina. And Jamie. And today we have someone who's so effing impressive on all levels. And I don't even think I need to say anything because we're going to get into the

1:11.8

meat of the things that you are, which if people don't know these things, then they have been

1:16.4

living under a rock. So it's a buddy of mine who I haven't seen in a long time and whom I

1:23.7

adore. Freaking Megan Malale. Oh my gosh.

1:28.8

I know.

1:29.5

Yay.

1:30.3

Thanks for having me.

1:31.3

I'm excited.

1:32.3

Welcome to messy.

1:33.8

We're so happy to have you here.

1:35.2

I've always, well, we know each other, you know, like on a, you know, semi-personal

...

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