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Well Beyond 40

Lose the Weight Loss Meds with Dr. James Hill

Well Beyond 40

JJ Virgin

Nutrition, Fitness, Health & Fitness

4.51K Ratings

🗓️ 17 December 2025

⏱️ 53 minutes

🧾️ Download transcript

Summary

When coming off weight loss medications, how can you prevent your appetite from surging? Also, how can you keep the weight off? In this episode, I explore with Dr. James Hill what really keeps weight off for good. We break down why the strategies that help you lose weight are not the same strategies that help you maintain it, especially in the era of GLP-1 medications. Together, we uncover the science-backed habits and mindset shifts that can help you create a lifestyle that supports your healthiest, happiest self for life. Dr. James Hill is a world-renowned obesity researcher who’s spent over 40 years studying how people lose weight, and more importantly, how they keep it off. He’s the co-founder of the National Weight Control Registry and author of a new book that helps people transition off GLP-1 medications without regaining weight, all delivered with his signature clarity, compassion, and common sense. What you’ll learn: (05:01) Why only about 20% of people keep weight off long-term and why this number may be even lower. (08:19) Why weight loss and weight maintenance require completely different strategies. (11:22) How GLP-1 medications have changed the landscape by helping more people finally reach their goal weight. (12:17) The three pillars of long-term weight maintenance: appetite management, physical activity, and mind state. (14:38) Why pairing high protein intake with resistance training helps protect muscle and improves metabolic health. (22:22) How “mind state” influences your ability to overcome setbacks. (31:26) Why successful maintainers average around 12,000 steps a day and schedule one hour of planned exercise daily. (35:30) The early signs of weight regain. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/hill Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Hey, JJ here. Can you believe how fast the holidays are knocking at the door this year?

0:05.9

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0:22.0

together fast, and for way less. With Wayfair, I know I can refresh my guest room in no time. Maybe I'll

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add a soft new comforter or a few holiday throw pillows. With Wayfair, it's so easy, and everything

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Wayfair has your back.

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And when the holidays wind down,

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Wayfair has everything you need to tuck it all neatly away.

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1:04.7

Get organized, refreshed, and ready for the holidays for way less.

1:08.6

Head to Wayfair.com right now to shop all things home.

1:16.8

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1:23.0

Hey, it's JJ here. You know I've been talking about environmental toxins forever, and laundry detergent is a sneaky one. A lot of them contain harsh chemicals like dyes, preservatives, and even UV

1:30.3

brighteners. Those brighteners don't actually clean anything. They just coat fabric so your eyes think

1:37.2

things look whiter or brighter. That's more chemicals. I don't want on my family sheep's or

1:42.7

skin. And if you've got sensitive skin or allergies around the

1:45.9

house, this can be a big problem. That's what got my attention about earth breeze. It looks like a

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