Is This Right for Me? NAD+: Why the "Longevity Molecule" Story Just Got Complicated

Commune with Jeff Krasno

Commune Media

Society & Culture, Health & Fitness

4.5 • 673 Ratings

🗓️ 2 June 2026

⏱️ 55 minutes

🔗️ Recording | iTunes | RSS

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Summary

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits. You’ll learn about: What NAD+ does in the body and why it got tied to aging The new research questioning whether NAD+ truly declines with age Oral NR and NMN versus IV infusions, and what the evidence supports The risks rarely mentioned, including the cancer question Why the saline, B vitamins, and forced rest may explain how good people feel This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line. Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

Transcript

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0:00.0	Okay, here's a moment that I keep having in La La Land, Los Angeles. I'll be driving down the sunset
0:05.5	strip and I'll pass three different Ivy drip lounges within the span of about four blocks.
0:12.5	One next to a med spa. One tucked between a Pilates studio and a juice bar and maybe a dry cleaner.
0:19.8	Another promising cellular optimization in a softly bar and maybe a dry cleaner, another promising cellular optimization
0:22.6	in a softly backlit lettering that looks vaguely religious. And I find myself thinking,
0:29.6	wait, hold on, are these people all onto something? Or are we witnessing the luxurification
0:35.3	of saline? Because the iv IV drip economy has absolutely exploded.
0:41.5	Hangover drips, beauty drips, athletic recovery drips, immune drips, brain optimization drips.
0:47.0	You can now summon a nurse practitioner to your house in a sprinter van and have fluids administered in your living room
0:55.7	like you're a dehydrated prune. And lately, the drip that is dripping into my DMs is
1:02.6	NAD, the longevity molecule, the mitochondrial miracle, the four-hour infusion that biohackers swear sharpens cognition, boosts energy, slows aging,
1:14.3	and possibly parts the Red Sea. So naturally, I got a little bit curious. Is NAD therapy actually
1:22.3	one of the more promising tools in longevity science? Or is this just wellness culture discovering a way to turn
1:29.7	sitting in a recliner with an IV into a status simple? Welcome to the commune podcast. My name is
1:41.5	Jeff Krasno and welcome back to the series that I started a couple of months ago called
1:45.9	Is This Right for Me? Where we slow down on the protocols, supplements, therapies, and treatment, flooding your Instagram feed, and ask the only question that actually matters.
1:58.2	Not whether something is trending, not whether your favorite podcaster is
2:02.5	doing it, not whether some celebrity just posted about it on a Tuesday, but whether for you in your
2:08.9	body with your history, with your risk profile, your circumstances, is it actually the right
2:14.4	call? Because the answer is almost never the same for everyone. And nobody
2:19.8	is selling you the protocol that is going to tell you that. Quick note, before we get into this one,
2:25.5	I had a version of this script ready to go a couple of weeks back. Then a paper landed in
	...

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