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Commune with Jeff Krasno

Is This Right for Me? Everything You Need to Know About GLP-1s

Commune with Jeff Krasno

Commune Media

Society & Culture, Health & Fitness

4.5673 Ratings

🗓️ 7 April 2026

⏱️ 47 minutes

🧾️ Download transcript

Summary

Every week, there's a new peptide, protocol, or wellness supplement your group chat won't stop talking about. The information is everywhere. The clarity is not."Is This Right for Me?" is a new Commune Podcast series built for exactly that moment. Each episode takes one treatment, therapy, or supplement that keeps flooding your feed and does the one thing the internet rarely does: slows down, looks at the actual evidence, and helps you figure out if it makes sense for you specifically.The first episode tackles GLP-1s. Ozempic, Wegovy, Mounjaro, Zepbound. Jeff breaks down how they work, what the clinical trials actually showed, and what the wellness internet keeps leaving out.This episode covers: What GLP-1s are and how they work in the body The real clinical trial data on semaglutide and tirzepatide What happens to your weight when you stop taking them Muscle loss, gallstones, thyroid risk, and side effects worth knowing Who these drugs make sense for and who they don't The compounding pharmacy crackdown and what it means for you What "natural GLP-1s" actually are and aren't The lifestyle habits that work on the same systems without a prescription This episode was made possible by: Beyond BioHacking: Save $400 on any ticket with code COMMUNE400 at beyondconference.com. Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at vivobarefoot.com/commune. Bon Charge: Get 15% off when you order at boncharge.com and use promo code COMMUNE  Sunlighten:  Visit sunlighten.com/commune and use code COMMUNE when you fill out the “Get Pricing’ form to save up to $1,600 on your purchase. LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.

Transcript

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0:00.0

Welcome to the Commune podcast. My name is Jeff Krasnow.

0:07.0

So there's a question that I keep getting asked in my DMs after my public talks,

0:13.0

from friends at dinner who pull me aside and lower their voices like they're asking me about something illicit.

0:20.0

The question isn't what what should I do?

0:22.7

It's actually more specific than that.

0:25.3

It's, is this thing that I've been reading about actually worth doing?

0:29.9

Or is it just influencer noise?

0:33.0

So that question is the entire premise of this series I'm launching titled, Is This Right for Me?

0:39.9

So we hear a commune have created this podcast series dedicated to the protocols, therapies, supplements, and treatments that keep showing up in your Instagram feed and your group chat.

0:50.7

Treatments like peptides, GLP1s, continuous glucose monitors, psychedelic therapy.

0:56.8

I'm not here to hype them nor to dismiss them, but to simply slow it down, look at the

1:02.0

evidence, understand the risks, and ask the only question that actually really matters, not

1:07.9

whether it's fashionable, but whether it's appropriate for you. I've done

1:13.1

the reading and the research, so you don't have to do all of it. But I'll tell you where the

1:18.2

reading led me, and you can be armed with the information to decide for yourself. Okay, let's get

1:25.1

into it. A couple of years ago, I slapped a continuous glucose

1:28.6

monitor on my triceps and learned something I genuinely did not want to know. I was by all

1:35.4

outward appearances a reasonably healthy person. I ran a wellness company after all. I did exercise.

1:41.2

I ate it whole foods, which as anyone who has ever shopped there can

1:45.2

attest, makes you feel morally superior, even if you mostly bought crackers and kombucha. And yet,

1:51.7

the CGM told a completely different story. My fasting blood glucose was hovering around

1:56.5

125 milligrams per deciliter. My post-perandial spikes were cresting to 200. So I was really without

...

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