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Age Better with Liz Earle

Hormones or histamine? Understanding your midlife symptoms – with Dr Clare Ashby

Age Better with Liz Earle

Liz Earle

Self-improvement, Fitness, Gut Health, Supplements, Beauty, Health, Hormones, Health & Fitness, Liz Earle, Exercise, Healthy Ageing, Menopause, Better Second Half, Women's Health, Arts, Wellbeing, Education, Midlife, Fashion & Beauty, Skincare

4.61.5K Ratings

🗓️ 3 April 2026

⏱️ 44 minutes

🧾️ Download transcript

Summary

Could your anxiety, brain fog, IBS and itchy skin be signs of something more than midlife hormonal changes? Dr Clare Ashby, histamine intolerance and MCAS specialist joins Liz to reveal the condition that's often overlooked – and how it can make HRT less effective.


In this episode, Liz and Clare discuss how symptoms we might have normalised for years could be signs of histamine intolerance, how it can be confused with perimenopause, and how healthy diet choices could be working against us.


Clare also explains how hormones and histamines work together, the food and lifestyle adjustments that can reduce reactivity, and the simple over-the-counter remedy that can make the world of difference.


In this episode:

·     How hormone changes in midlife can lead to histamine imbalance

·     The signs you may be histamine intolerant

·     Why your HRT might not be working effectively

·     Is avocado on sourdough making you ill?

·     The surprising link between mast cell disorder, hypermobility, ADHD and IBS

·     How over-the-counter antihistamines can help more than hay fever

 

Links mentioned in the episode:

·     Pulsetto

·     Neurosim

·     The Gupta natural healing programme

·     The British Dietetic Association

 

More from Clare:

Work with Clare

More about histamine

 

Get in touch with a question for Liz:

- Email: podcast@lizearlewellbeing.com

- WhatsApp: 07518 471 846

 

More from Liz:

Preorder Liz's new book – How to Age

A Better Second Half

Follow Liz on Instagram

Follow Liz Earle Wellbeing on Instagram

 

Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information.

 


Hosted on Acast. See acast.com/privacy for more information.

Transcript

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0:00.0

disorder muscle behavior really falls between the cracks of allopathic medicine because if you have

0:07.0

a skin reaction, you go see a dermatologist, if you have palpitations, you go and see a cardiologist,

0:13.0

if you have uterine, disordered and heavy bleeding, you see a gynecologist. Well, the mast cells are in

0:18.5

every tissue and they communicate so beautifully together that they are

0:22.8

causing multiple symptoms in multiple organ systems for many patients.

0:28.7

Well, Dr. Claire Ashby is a histamine intolerance and MCAS specialist.

0:34.9

Your IBS, anxiety, brain fog.

0:40.2

Well, she says they could all be signs of a disordered mast cell behaviour. I'm Liz Earle. Welcome to Age Better. My mission is to change

0:47.5

the conversation around aging because women's health, especially as we age, has frankly

0:53.5

been underfunded and overlooked for far too long.

0:57.2

And I do think it's time we pushed back. And through this podcast, I really want to share

1:02.5

the tools that can help you thrive in later life by taking action today. And I also want to

1:08.8

bring your attention to signs and symptoms and conditions that you

1:12.7

might be less familiar with, to arm yourself with the knowledge to advocate for yourself

1:18.0

in a healthcare setting. Well, Claire Ashby is a private GP. She's dual trained in allopathic

1:24.9

medicine and functional medicine, alongside the menopause she specialises

1:29.7

in histamine intolerance and MCAS. That stands for mast cell activation syndrome. Something that I got

1:37.8

to know about, unfortunately, all too well with my own eldest daughter, Lily. Many of you

1:42.5

will have followed her journey on podcasts here,

1:45.0

and it was really the root of so many of her autoimmune issues, and it took a long time to be

1:51.1

diagnosed and even longer, really, to be recognised by the allopathic medical profession.

1:56.9

It now is, of course, and she's now getting lots of help. But also, to a lesser extent,

...

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