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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Guanfacine Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 23 November 2023

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this episode of the podcast, I cover guanfacine pharmacology, adverse effects, drug interactions, and much more.



Guanfacine is a central acting alpha-2 agonist that has the brand names of Tenex and Intuniv.



Because of guanfacine's mechanism of action, it suppresses the sympathetic response leading to a drop in pulse and blood pressure.



It is important to remind patients that the onset of action is slow in the management of ADHD with guanfacine. I discuss this further in this podcast episode.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast.

0:03.5

I'm your host pharmacist Derek Christensen.

0:05.5

Thank you so much for listening today.

0:08.1

As always, go check out Real Life Pharmacology.com.

0:11.6

Subscribe to our email list there.

0:13.8

Simply with an email, you'll get access to a free PDF.

0:18.4

It's 31 pages on the top 200 drugs, some of the most important things that I've seen in clinical practice,

0:25.6

as well as things that will likely show up on pharmacology and board exams.

0:31.0

So great opportunity for students as well as those just looking to refresh their medication education in practice.

0:41.6

All right, the drug of the day today is Guan Fasine.

0:45.7

Brand name of this medication is 10X.

0:49.1

Other brand name medication you might see is intiniv.

0:53.7

This drug, its mechanism of action, is an alpha 2A receptor agonist, and it primarily works

1:02.1

in the central nervous system, and it reduces sympathetic outflow.

1:10.6

So remember, when you hear sympathetic,

1:14.2

that means the fight or flight response, right?

1:17.7

Where we've got an increase in blood pressure, heart rate,

1:20.6

things of that nature.

1:22.8

So this drug is going to reduce that,

1:25.8

and it does it by ultimately kind of reducing the effects

1:29.9

of noraphenephrine.

1:32.2

So that's going to lead to a reduction in vasoconstriction, which could lead to lower blood

...

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