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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Fluvastatin Pharmacolgy Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 16 November 2023

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this podcast episode, I discuss fluvastatin pharmacology, adverse effects, pharmacokinetics, and much more.



Fluvastatin is only a low to moderate-intensity statin which explains its limited use compared to rosuvastatin or atorvastatin.



I discuss drug interactions in the podcast but one important one to recognize is drugs that can inhibit CYP2C9.



Fluvastatin is considered a lipophilic statin. I have previously discussed this on the Meded101 blog which you can find here.

Transcript

Click on a timestamp to play from that location

0:00.0

Hey all, welcome back to the real-life pharmacology podcast. I'm your host pharmacist, Eric Christensen.

0:05.9

Thank you for listening today. As always, go check out the top 200 study guide I have put together.

0:13.5

It's a 31-page PDF. It's a great review if you're taking any pharmacology classes or board exams or anything in relation to that

0:22.5

definitely a great refresher of some of the most important clinical pearls from practice as well as

0:28.5

things that are likely to be tested on from my experience if you're out in practice it's also a great

0:33.8

little refresher to make sure you're up to speed on the latest top 200 drugs.

0:39.2

So again, take advantage of that.

0:41.6

RealLife Pharmacology.com simply an email.

0:44.4

We'll get you access to that.

0:47.4

All right.

0:47.8

The drug of the day today is fluvastatin.

0:51.3

Brand name of this medication is Lescal.

0:57.4

This medication is used to lower cholesterol,

1:06.6

primarily with a focus on LDL. And it works. It is a statin medication. It works by inhibiting HMG-CoA reductase. If you remember, that is a very important enzyme that is responsible for

1:14.2

essentially the production of cholesterol and LDL. Dosing of this medication, so you may not be

1:24.3

terribly familiar with fluvastatin because it's not a commonly used statin.

1:30.9

The big reason being is it is not a high-intensity statin.

1:39.1

So if we need, if we've got patients at high risk for cardiovascular disease or they've had a heart

1:45.4

attack, stroke, things of that nature, and we need more aggressive cholesterol lowering therapy,

1:52.2

fluvastatin is not going to be it. And so you're much more likely to see a torvastatin and

1:57.5

rosuvastatin used instead of fluvastatin. With that said, I have seen it,

2:03.6

definitely occasionally used. It does cover low intensity LDL lowering as well as moderate

...

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