Ranolazine (Ranexa) Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 3 November 2022

⏱️ 14 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Ranolazine is primarily used for chronic angina management. I discuss pharmacology, drug interactions, adverse effects, and more in this podcast episode.

Ranolazine is well known to have drug interactions. CYP3A4 is of major importance but there are other subtle drug interactions that are important.

QTc prolongation has been reported with ranolazine so it is important to recognize risk factors and other medications that may contribute to this concern.

Enzyme inducers like carbamazepine, phenytoin, and St. John's wort are all associated with reducing the concentrations of ranolazine.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.
0:05.5	Thank you so much for listening today. As always, go check out Real Life Pharmacology.com.
0:11.6	We got your top 200 study guide, 31 page PDF, absolutely no cost to you, simply an email to get you on our subscription list, and we email you out
0:24.5	when we've got new podcasts and content available. So again, absolutely no cost to you. RealLifepharmacology.
0:31.5	com. Go subscribe and get that free Top 200 study guide. Appreciate the support there, of course, as always.
0:40.3	The drug of the day today is rhinolazine.
0:44.0	Brand name of this medication is Renexa,
0:46.6	and I specifically had somebody reach out
0:49.1	that wanted this drug covered,
0:51.2	and I will certainly oblige.
0:57.1	I can't say it's a drug that I see used really often. I can say it's probably a medication I've maybe seen 10 to 20 times in my career. So very,
1:06.5	very seldom is this medication used.
1:17.9	Its primary use and the only use I've ever seen it used for is chronic anginaum.
1:24.3	It does have the off-label use of ventricular tachycardia.
1:26.2	I've never seen it used for that.
1:29.5	So I really don't have any experience in seeing it for that. But that is a reported off label use. So with that chronic end, you know, that's
1:36.5	obviously what I'm going to focus on most. It is not intended for acute relief. So it's nothing like sublingal nitroglycerin, for example.
1:48.0	So that's first patient education point to remember.
1:52.6	It's not going to generally alleviate quickly an episode of angina or chest pain.
2:02.2	Now, most often for chronic angina,
2:04.9	the drugs that are utilized for kind of chronic management
2:07.9	and reducing angina symptoms over time,
	...

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