Hello and welcome to the Consistency Project podcast. I'm Patrick Cummings here as always with

E.C. Sinkowski every week we aim to simplify the principles and practices of nutrition,

health and fitness. We thank you for tuning into the show this week. Hello, E.C. How are you?

Good. How are you doing?

Wonderful. We're going to return to some listener questions to a quick bite's format,

which is when we try to do five listener questions in about five minutes each. Cool? Yeah. All right. So we've got five new questions before we do. We've been talking about this the last couple weeks. If folks out there are running events or conferences or birthday parties or high school reunions and they want to have EC if they want to have

you come and talk to them about fruits and vegetables and protein. We can do that now. Optimizemenutrition

dot com slash speaking is the way to do that. Anything you want to add to that EC? We were joking

kids' birthday parties. That might not be the best venue. They might want to, I don't know, do something more fun than listen about fruits and vegetables. But yeah, corporate wellness events, conferences, I think there's a lot of different ways that can work out. So just reach out to me at slash speaking and we'll figure out if it's a good fit and what you're looking for. Awesome. All right. Like I said, five questions. Let's jump right into it. This first one's from Spencer.

He said, I got a 23-and-me test done a few years ago and got a result showing that I got one APOE4 variant.

This is always classified as the, quote, Alzheimer's gene. A few months ago, I got a standard blood

panel and my LDL cholesterol had gone from about 100

to about 130.

What are the diet implications for someone who has the APOE4 gene variant?

Yeah.

Yeah.

So the APOE gene is a gene that regulates how your body transports and processes fats and cholesterol,

especially in the brain. And humans typically have two copies of the APOE variant, one from each parent,

of course. And there are three common variants, APOE2, APOE3. That one actually is the most common,

is kind of considered neutral.

And then APOE4, this is the one that people talk about all the time, as Spencer mentioned, because of the disease risk, especially with Alzheimer's, but yes, also with LDL cholesterol, which is our, quote, bad cholesterol.

Now, APOE4 is the strongest common genetic risk factor for late onset Alzheimer's.

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