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The Science of Everything Podcast

Episode 34: DNA Structure and Function Part 1

The Science of Everything Podcast

James Fodor

Social Sciences, Natural Sciences, Science

4.8819 Ratings

🗓️ 30 June 2012

⏱️ 44 minutes

🧾️ Download transcript

Summary

In part 1 of this two-part episode, I discuss the double helix shape of DNA, the structure of nucleotides, base-paring between nitrogenous bases, the genetic code, codons, DNA reading frames, the one-gene one-polypeptide hypothesis, and the Central Dogma of Molecular Biology. This basic structural knowledge will provide the basis for a more detailed discussion of the processes of DNA replication, transcription and translation in part 2 of this topic. Recommended background knowledge of episodes 10 (The Cell) and 18 (Biochemistry Basics).

Transcript

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0:00.0

Oh, wow, oh, oh, wow, oh, wow, oh, man.

0:15.0

Oh, my.

0:16.0

And so, you're listening to The Science of Everything podcast, episode 34.

0:38.1

DNA, structure and function. And I'm your host, James Fodor.

0:41.9

In this episode, I'm going to look at DNA and genes, and particularly talk about the structure of DNA, the double helix structure, and how that's put together by the nucleotide-based pairs and how that relates to the genetic code.

0:54.8

We'll also discuss the central dogma of molecular biology, which is basically that DNA translates to RNA,

1:00.5

which then makes proteins. And in doing so, we'll look at the separate processes of DNA replication,

1:05.8

DNA-R-N-R-A transcription, and also RNA-to-protein translation. Now, this episode has some prerequisites,

1:13.3

if you will. It's recommended that you have listened to episode 10 about the cell and

1:18.1

episode 18, biochemistry basics. I think those episodes themselves also have some prerequisites.

1:23.8

But basically some background about the structure of the cell and some knowledge of biomolecules and polymer chains and stuff like that would be very helpful for this episode.

1:34.4

Okay, so there's a lot to go through in this episode, so let's get started.

1:39.2

First of all, we'll talk about the structure of DNA.

1:42.3

So first of all, DNA is an acronym, which stands for

1:46.1

deoxyribonucleic acid, which is the name for the monomer, that is the molecules, that make

1:53.9

up the DNA structure. Each of these little monomer molecules are called nucleotides,

2:00.6

and as I said, they're a class of organic monomers.

2:02.6

They make up both DNA and RNA, actually.

2:04.6

Each nucleotide has a particular structure, and then you sort of link them all together in a big long chain to form a polymer.

2:11.6

Remember this from the biochemistry episode, the many monomers go into make a polymer.

2:16.6

The DNA itself is a polymer, but the

2:18.4

nucleotides are the monomers that make up the polymer. But each nucleotide, the monomer,

...

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