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The Science of Everything Podcast

Episode 35: DNA Structure and Function Part 2

The Science of Everything Podcast

James Fodor

Social Sciences, Natural Sciences, Science

4.8819 Ratings

🗓️ 3 July 2012

⏱️ 52 minutes

🧾️ Download transcript

Summary

Continuing on from episode 34, I discuss in detail the processes of DNA replication, transcription from DNA to RNA, and the translation of RNA to proteins. In doing so I examine the molecules and structures involved, the mechanisms of their operation, and how all the processes work together to facilitate the production of proteins from DNA.

Transcript

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0:00.0

Oh, wow, oh, oh, wow, oh, wow, oh, man.

0:15.0

Oh, wow. Hello there. You're listening to The Science of Everything podcast, episode 35, DNA, structure, and function, part two.

0:40.7

So in this episode, we're going to continue directly from episode 34, so pretty good idea to listen to that first,

0:46.4

where I talked about the structure of DNA, including nucleotides, how they're connected together,

0:51.2

the different types of nitrogenous bases that are connected to the nucleotides,

0:57.1

well, a part of the nucleotides, and form the double-stranded structure of the DNA double helix.

1:02.6

We also talked about the genetic code, including the central dogma of molecular biology,

1:06.9

the one-gene-one-protein hypothesis, we talked about codons and the reading frame.

1:11.6

In this episode, what we're going to do is look at the details of how the central dogma works.

1:16.0

We're going to look at how we get from DNA to RNA and how we get from RNA to proteins.

1:21.1

Specifically, we're going to look at the processes of replication, transcription, and translation,

1:25.1

including how they start, or how they activated, how they

1:27.9

are continued, how they terminated, and how all that fits together and the structures that carry

1:32.6

these processes out. Let's get into it. We'll start with replication. So replication is actually

1:37.8

not exactly part of the central dogma because this is just about how DNA replicates itself,

1:41.8

or how we go from one DNA strand to two DNA strands,

1:45.3

contain essentially the same information. So DNA replication is the process by which a cell's

1:50.3

entire DNA is copied or replicated. This process occurs during the synthesis phase of the

1:55.8

eukaryotic cell cycle. So we haven't actually talked about the cell cycle before. That's a topic I

2:00.2

need to cover, actually. But there are different cell Cell cycles basically the cycle of life for cells, and there are different phases to that cycle.

2:06.6

One of them is called the synthesis phase, and it basically refers to the time when DNA is copying itself.

2:10.6

And that's important because if you're going to have a cell that divides up into two cells, you know, that replicates itself, obviously each of those

...

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