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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Doxycycline Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 25 November 2021

⏱️ 15 minutes

🧾️ Download transcript

Summary

On this episode of the Real Life Pharmacology podcast, I explore doxycycline pharmacology, adverse effects, and drug interactions.



Doxycycline can be bound by numerous minerals like calcium, magnesium, and iron. Coadministration can lead to reduced concentrations.



Sun sensitivity is a really important adverse effect that can be caused by doxycycline. Be sure to educate your patients.



Doxycycline can be used as an alternative to beta-lactams and macrolides in the management of community-acquired pneumonia.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist, Eric Christensen.

0:06.5

Thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

0:13.6

Go subscribe there and get our free 31 page PDF. It's of the top 200 drugs. It's a study guide.

0:21.7

I pull out real world clinical practice

0:24.5

pearls as well as things that

0:26.9

often show up on pharmacology and board exams.

0:30.3

So definitely don't want to go without that

0:32.7

resource. Great, free opportunity there for you

0:36.5

to have something to kind of refresh yourself of some of the most

0:40.4

important things from some of the top 200 medications.

0:45.2

All right, so let's get into the drug of the day today, and that is doxycycline.

0:51.0

Brand name is vibramycin.

0:53.7

In all honesty, I don't hear people call it that very often.

0:57.5

It's pretty much always doxocycline in clinical practice.

1:01.9

It is a tetracycline derivative,

1:05.6

and this is from the class of antibiotics, the tetracyclines.

1:11.3

And with that, the dosing is very similar and common in many, many conditions.

1:19.9

So 100 milligrams twice a day is kind of the standard treatment for any bacterial infection.

1:36.8

There's a couple of exceptions to that, but by and large, 100 milligrams twice a day is what you most frequently see as far as dosing goes.

1:46.5

Mechanistically, this drug binds the 30s, ribosomal portion of the ribosomal subunits,

1:51.2

which ultimately impairs protein synthesis of bacteria.

1:54.1

So as far as the replication growth process,

...

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