5 • 716 Ratings
🗓️ 25 November 2021
⏱️ 15 minutes
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0:00.0 | Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist, Eric Christensen. |
0:06.5 | Thank you so much for listening today. As always, go check out Real Life Pharmacology.com. |
0:13.6 | Go subscribe there and get our free 31 page PDF. It's of the top 200 drugs. It's a study guide. |
0:21.7 | I pull out real world clinical practice |
0:24.5 | pearls as well as things that |
0:26.9 | often show up on pharmacology and board exams. |
0:30.3 | So definitely don't want to go without that |
0:32.7 | resource. Great, free opportunity there for you |
0:36.5 | to have something to kind of refresh yourself of some of the most |
0:40.4 | important things from some of the top 200 medications. |
0:45.2 | All right, so let's get into the drug of the day today, and that is doxycycline. |
0:51.0 | Brand name is vibramycin. |
0:53.7 | In all honesty, I don't hear people call it that very often. |
0:57.5 | It's pretty much always doxocycline in clinical practice. |
1:01.9 | It is a tetracycline derivative, |
1:05.6 | and this is from the class of antibiotics, the tetracyclines. |
1:11.3 | And with that, the dosing is very similar and common in many, many conditions. |
1:19.9 | So 100 milligrams twice a day is kind of the standard treatment for any bacterial infection. |
1:36.8 | There's a couple of exceptions to that, but by and large, 100 milligrams twice a day is what you most frequently see as far as dosing goes. |
1:46.5 | Mechanistically, this drug binds the 30s, ribosomal portion of the ribosomal subunits, |
1:51.2 | which ultimately impairs protein synthesis of bacteria. |
1:54.1 | So as far as the replication growth process, |
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